Results 11 to 20 of about 90,280 (287)

Cationic Antimicrobial Peptides Inactivate Shiga Toxin-Encoding Bacteriophages [PDF]

Frontiers in Chemistry, 2017
Shiga toxin (Stx) is the principal virulence factor during Shiga toxin-producing Escherichia coli (STEC) infections. We have previously reported the inactivation of bacteriophage encoding Stx after treatment with chitosan, a linear polysaccharide polymer
Manuel E. Del Cogliano, Manuel E. Del Cogliano, Axel Hollmann, Axel Hollmann, Axel Hollmann, Melina Martinez, Melina Martinez, Liliana Semorile, Liliana Semorile, Pablo D. Ghiringhelli, Paulo C. Maffía, Paulo C. Maffía, Leticia V. Bentancor, Leticia V. Bentancor   +13 more
doaj   +5 more sources

Antimicrobial activity of cationic antimicrobial peptides against stationary phase bacteria

Frontiers in Microbiology, 2022
Antimicrobial peptides (AMPs) are ancient antimicrobial weapons used by multicellular organisms as components of their innate immune defenses. Because of the antibiotic crisis, AMPs have also become candidates for developing new drugs. Here, we show that
Alexandro Rodríguez-Rojas, Alexandro Rodríguez-Rojas, Jens Rolff, Jens Rolff   +3 more
doaj   +5 more sources

Cationic antimicrobial peptides: potential templates for anticancer agents

Frontiers in Medicine
Cancer is a major global health concern and one of the leading causes of death worldwide. According to the World Health Organization (WHO), there is an urgent need for novel therapeutic agents to treat this disease.
Yahson Fernando Varela-Quitián, Fabio Enrique Mendez-Rivera, David Andres Bernal-Estévez   +2 more
doaj   +3 more sources

Cationic Antimicrobial Peptide Cytotoxicity [PDF]

SOJ Microbiology & Infectious Diseases, 2014
Fluorescence microscopy serves as a valuable tool for assessing the structural integrity and viability of eukaryotic cells. Through the use of calcein AM and the DNA stain 4,6-diamidino-2 phenylindole (DAPI), cell viability and membrane integrity can be qualified. Our group has previously shown the ultra-short cationic antimicrobial peptide H-OOWW-NH2;
Laverty, Garry, Gilmore, Brendan
openaire   +3 more sources

Cationic Hydrophobic Peptides with Antimicrobial Activity [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT The MICs of cationic, hydrophobic peptides of the prototypic sequence KKAAAXAAAAAXAAWAAXAAAKKKK-amide (where X is one of the 20 commonly occurring amino acids) are in a low micromolar range for a panel of gram-negative and gram-positive bacteria, with no or low hemolytic activity against human and rabbit erythrocytes.
Margareta, Stark, Li-Ping, Liu, Charles M, Deber   +2 more
openaire   +2 more sources

Salt-Resistant Alpha-Helical Cationic Antimicrobial Peptides [PDF]

Antimicrobial Agents and Chemotherapy, 1999
ABSTRACT Analogues based on the insect cecropin–bee melittin hybrid peptide (CEME) were studied and analyzed for activity and salt resistance. The new variants were designed to have an increase in amphipathic α-helical content (CP29 and CP26) and in overall positive charge (CP26). The α-helicity of these peptides was demonstrated
C, Friedrich, M G, Scott, N, Karunaratne, H, Yan, R E, Hancock   +4 more
openaire   +2 more sources

Short Cationic Antimicrobial Peptides Interact with ATP [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase.
Hilpert, K., McLeod, B., Yu, J., Elliott, M. R., Rautenbach, M., Ruden, S., Bürck, J., Muhle-Goll, C., Ulrich, A. S., Keller, S., Hancock, R. E. W.   +10 more
openaire   +4 more sources

Antimicrobial peptides´ immune modulation role in intracellular bacterial infection

Frontiers in Immunology, 2023
Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to eliminate the infection because they have poor cellular uptake ...
Diana Ivonne Duarte-Mata, M. Salinas-Carmona   +1 more
semanticscholar   +1 more source

Evaluation of the Antimicrobial Activity of Cationic Peptides Loaded in Surface-Modified Nanoliposomes against Foodborne Bacteria

International Journal of Molecular Sciences, 2019
Bacteria are a common group of foodborne pathogens presenting public health issues with a large economic burden for the food industry. Our work focused on a solution to this problem by evaluating antibiotic activity against two bacteria (Listeria ...
Stefania Cantor, L. Vargas, Oscar E Rojas A, Cristhian J Yarce, Constain H. Salamanca, José Oñate-Garzón   +5 more
semanticscholar   +1 more source

The effect of lipidation and glycosylation on short cationic antimicrobial peptides.

Biochimica et Biophysica Acta - Biomembranes, 2020
The global health threat surrounding bacterial resistance has resulted in antibiotic researchers shifting their focus away from 'traditional' antibiotics and concentrating on other antimicrobial agents, including antimicrobial peptides.
E. Grimsey, D. Collis, R. Mikut, K. Hilpert   +3 more
semanticscholar   +1 more source