Results 21 to 30 of about 28,103 (254)
Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides
Frontiers in Microbiology, 2013 Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast potential as peptide-based drugs. Great effort has been made in order to exploit their mechanisms of action, aiming to identify their targets as well as to enhance their ...
Kelly eMulder +4 more
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Short Cationic Antimicrobial Peptides Interact with ATP [PDF]
Antimicrobial Agents and Chemotherapy, 2010 ABSTRACT The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase.
Hilpert, K. +10 more
openaire +3 more sources
Pharmaceuticals, 2013 Tryptophan and arginine-rich cyclic hexapeptides of the type cyclo-RRRWFW combine high antibacterial activity with rapid cell killing kinetics, but show low toxicity in human cell lines.
Margitta Dathe +4 more
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A review of the antiviral activity of cationic antimicrobial peptides
Peptides, 2023 Viral epidemics are occurring frequently, and the COVID-19 viral pandemic has resulted in at least 6.5 million deaths worldwide. Although antiviral therapeutics are available, these may not have sufficient effect. The emergence of resistant or novel viruses requires new therapies.
Urmi, Umme Laila +4 more
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Antibiotics, 2023 Here we designed and synthesized analogs of two antimicrobial peptides, namely C10:0-A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and used non-proteinogenic amino acids to improve their therapeutic properties. The physicochemical
Maria Veronica Humpola +6 more
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Role of membranes in the activities of antimicrobial cationic peptides [PDF]
FEMS Microbiology Letters, 2002 Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact ...
Robert E W, Hancock, Annett, Rozek
openaire +2 more sources
Antimicrobial peptides: the role of hydrophobicity in the alpha helical structure [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2013 The antimicrobial peptides (AMPs) are a class of molecule obtained from plants, insects, animals, and humans. These peptides have been classified into five categories: 1. Anionic peptide, 2. Linear alpha helical cationic peptide, 3.
Pandurangan Perumal, Vijaya P. Pandey
doaj
Functions of Cationic Host Defense Peptides in Immunity
Pharmaceuticals, 2016 Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution ...
Mahadevappa Hemshekhar +2 more
doaj +1 more source
Frontiers in Immunology, 2020 Cationic antimicrobial peptides (AMPs) are active immune effectors of multicellular organisms and are also considered as new antimicrobial drug candidates.
Alexandro Rodríguez-Rojas +8 more
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Antibacterial activity of active peptide from marine macroalgae Chondrus crispus protein hydrolysate against Staphylococcus aureus [PDF]
Pharmacia, 2023 Macroalgae is a protein source with the potential to yield antimicrobial peptides (AMPs) that exhibit a wide range of biological activities. This study aimed to find bioactive peptide-based antibacterial compounds from marine macroalgae Chondrus crispus ...
Ahmad Habibie +3 more
doaj +3 more sources