Results 11 to 20 of about 28,103 (254)

Antimicrobial peptide-inspired antibacterial polymeric materials for biosafety

Biosafety and Health, 2022
The emergence of antimicrobial resistance attributed to the overuse and abuse of antibiotics severely endangers global biosafety. Antimicrobial peptides (AMPs) produced by various living organisms exhibit broad-spectrum antimicrobial properties with a ...
Min Lin, Jing Sun
doaj   +1 more source

Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump

Microbiology Spectrum, 2022
Bacterial efflux pumps in the resistance-nodulation-cell division (RND) family of Gram-negative bacteria contribute significantly to the development of antimicrobial resistance by many pathogens. In this study, we selected the MtrD transporter protein of
Meinan Lyu, Julio C. Ayala, Isabella Chirakos, Chih-Chia Su, William M. Shafer, Edward W. Yu   +5 more
doaj   +1 more source

Characterization of the Hemolytic Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins, 2023
Biologically active peptides have attracted increasing attention in research on the development of new drugs. Mastoparans, a group of wasp venom linear cationic α-helical peptides, have a variety of biological effects, including mast cell degranulation ...
Xiangdong Ye, Huajun Zhang, Xudong Luo, Fengyin Huang, Fang Sun, Liangbin Zhou, Chenhu Qin, Li Ding, Haimei Zhou, Xin Liu, Zongyun Chen   +10 more
doaj   +1 more source

Cationic Hydrophobic Peptides with Antimicrobial Activity [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT The MICs of cationic, hydrophobic peptides of the prototypic sequence KKAAAXAAAAAXAAWAAXAAAKKKK-amide (where X is one of the 20 commonly occurring amino acids) are in a low micromolar range for a panel of gram-negative and gram-positive bacteria, with no or low hemolytic activity against human and rabbit erythrocytes.
Margareta, Stark, Li-Ping, Liu, Charles M, Deber   +2 more
openaire   +2 more sources

Cationic Antimicrobial Peptides Inactivate Shiga Toxin-Encoding Bacteriophages

Frontiers in Chemistry, 2017
Shiga toxin (Stx) is the principal virulence factor during Shiga toxin-producing Escherichia coli (STEC) infections. We have previously reported the inactivation of bacteriophage encoding Stx after treatment with chitosan, a linear polysaccharide polymer
Manuel E. Del Cogliano, Manuel E. Del Cogliano, Axel Hollmann, Axel Hollmann, Axel Hollmann, Melina Martinez, Melina Martinez, Liliana Semorile, Liliana Semorile, Pablo D. Ghiringhelli, Paulo C. Maffía, Paulo C. Maffía, Leticia V. Bentancor, Leticia V. Bentancor   +13 more
doaj   +1 more source

Cationic Antimicrobial Peptide Cytotoxicity [PDF]

SOJ Microbiology & Infectious Diseases, 2014
Fluorescence microscopy serves as a valuable tool for assessing the structural integrity and viability of eukaryotic cells. Through the use of calcein AM and the DNA stain 4,6-diamidino-2 phenylindole (DAPI), cell viability and membrane integrity can be qualified. Our group has previously shown the ultra-short cationic antimicrobial peptide H-OOWW-NH2;
Laverty, Garry, Gilmore, Brendan
openaire   +3 more sources

Antimicrobial activity and synergistic effect of phage-encoded antimicrobial peptides with colistin and outer membrane permeabilizing agents against Acinetobacter baumannii [PDF]

PeerJ
Background Acinetobacter baumannii poses a significant public health threat. Phage-encoded antimicrobial peptides (AMPs) have emerged as promising candidates in the battle against antibiotic-resistant A. baumannii. Methods Antimicrobial peptides from the
Punnaphat Rothong, Udomluk Leungtongkam, Supat Khongfak, Chanatinat Homkaew, Sirorat Samathi, Sarunporn Tandhavanant, Jatuporn Ngoenkam, Apichat Vitta, Aunchalee Thanwisai, Sutthirat Sitthisak   +9 more
doaj   +2 more sources

Recent advances in the field of antimicrobial peptides in inflammatory diseases

Advanced Biomedical Research, 2013
Antimicrobial peptides are cationic molecules, which participate in multiple aspects of the immune response including the control of inflammatory diseases, characteristic that make these molecules attractive as therapeutic tools.
Patricia Méndez-Samperio
doaj   +1 more source

Interaction of Cationic Antimicrobial Peptides with Model Membranes [PDF]

Journal of Biological Chemistry, 2001
A series of natural and synthetic cationic antimicrobial peptides from various structural classes, including alpha-helical, beta-sheet, extended, and cyclic, were examined for their ability to interact with model membranes, assessing penetration of phospholipid monolayers and induction of lipid flip-flop, membrane leakiness, and peptide translocation ...
L, Zhang, A, Rozek, R E, Hancock
openaire   +2 more sources

Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

Antibiotics, 2022
Antimicrobial peptides (AMPs) have received increasing attention as potential alternatives for future antibiotics because of the rise of multidrug-resistant (MDR) bacteria.
Su-Jin Kang, So Hee Nam, Bong-Jin Lee
doaj   +1 more source