Results 41 to 50 of about 53,767 (297)

A novel antibacterial peptide derived from Crocodylus siamensis haemoglobin hydrolysate induces membrane permeabilization causing iron dysregulation, oxidative stress and bacterial death [PDF]

, 2017
Aims A novel antibacterial peptide from Crocodylus siamensis haemoglobin hydrolysate (CHH) was characterized for antimicrobial activity. Methods and Results CHHs were hydrolysed for 2 h (2 h-CHH), 4 h (4h-CHH), 6 h (6 h-CHH) and 8 h (8 h-CHH). The
Adje, Ali, Arroume, Arroume, Chitemerere, Daoud, Froidevaux, Gault, Jandaruang, Jangpromma, Kabbua, Maddocks, Maijaroen, Mbah, Michel, Miller, Osman, Pakdeesuwan, Pata, Phosri, Phosri, Sato, Schwyn, Solanky, Song, Srihongthong, Vasilchenko, Winkelmann, Yu, Zheng   +29 more
core   +2 more sources

Interaction of cationic antimicrobial peptides with Mycoplasma pulmonis [PDF]

FEBS Letters, 2013
We investigated the mode of action underlying the anti‐mycoplasma activity of cationic antimicrobial peptides (AMPs) using four known AMPs and Mycoplasma pulmonis as a model mycoplasma. Scanning electron microscopy revealed that the integrity of the M.
Park, Ho Jin, Kang, Ki Mo, Dybvig, Kevin, Lee, Bok Luel, Jung, Yong Woo, Lee, In Hee   +5 more
openaire   +2 more sources

Racing on the Wrong Track

Frontiers in Chemistry, 2017
The preclinical in vitro and in vivo benchmark figures of cationic antimicrobial peptides have to be revisited based on the newly discovered alternative modes of action.
Laszlo Otvos, Laszlo Otvos
doaj   +1 more source

A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. [PDF]

, 2005
Blood. 2005 Oct 15;106(8):2922-3. A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron.
Almeida, S., Bacelar, C., Camaschella, C., Daraio, F., Ganz, T., Nemeth, E., Pinto, J., Porto, G., Roetto, A.   +8 more
core   +1 more source

Identification of New Ocellatin Antimicrobial Peptides by cDNA Precursor Cloning in the Frame of This Family of Intriguing Peptides

Antibiotics, 2020
Ocellatins are a family of antimicrobial peptides found exclusively in the Leptodactylus genus. To date, 10 species have been studied and more than 23 peptides described.
Mariela M. Marani, Silvana Aguilar, Ana P. Cuzziol Boccioni, Natalia L. Cancelarich, Néstor G. Basso, Fernando Albericio   +5 more
doaj   +1 more source

Binding of cationic analogues of α-MSH to lipopolysaccharide and disruption of the cytoplasmic membranes caused bactericidal action against Escherichia coli

Scientific Reports, 2022
In earlier reports, we have shown the antimicrobial activity of a host neuropeptide, alpha-melanocyte stimulating hormone (α-MSH) and its cationic analogues against Staphylococcus aureus.
Kanchan Tiwari, Madhuri Singh, Prince Kumar, Kasturi Mukhopadhyay   +3 more
doaj   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources

Microbial Cationic Peptides as a Natural Defense Mechanism against Insect Antimicrobial Peptides

ACS Chemical Biology, 2021
Bacteria produce a plethora of specialized metabolites (SM), with the ecological function of most of them not known. A major group of SM are peptides derived from nonribosomal peptide synthetases (NRPS). In entomopathogenic bacteria of the genus Xenorhabdus, PAX (peptide-antimicrobial-Xenorhabdus) were described as NRPS-derived lipopeptides, which show
Tien Duy Vo, Christoph Spahn, Mike Heilemann, Helge B. Bode   +3 more
openaire   +4 more sources

Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics

Antibiotics, 2015
Multicellular organisms are constantly exposed to a multitude of pathogenic microbes. Infection is inhibited in vivo by the innate and adaptive immune system. Mycobacterium species have emerged that are resistant to most antibiotics.
Kajal Gupta, Sameer Singh, Monique L. van Hoek   +2 more
doaj   +1 more source

Antimicrobials, stress and mutagenesis.

PLoS Pathogens, 2014
Cationic antimicrobial peptides are ancient and ubiquitous immune effectors that multicellular organisms use to kill and police microbes whereas antibiotics are mostly employed by microorganisms.
Alexandro Rodríguez-Rojas, Olga Makarova, Jens Rolff   +2 more
doaj   +1 more source