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Antimicrobial Peptides: An Introduction
2016The "golden era" of antibiotic discovery has long passed, but the need for new antibiotics has never been greater due to the emerging threat of antibiotic resistance. This urgency to develop new antibiotics has motivated researchers to find new methods to combat pathogenic microorganisms resulting in a surge of research focused around antimicrobial ...
Evan F, Haney +2 more
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Antimicrobial Peptides in the Airway
2006The airway provides numerous defense mechanisms to prevent microbial colonization by the large numbers of bacteria and viruses present in ambient air. An important component of this defense is the antimicrobial peptides and proteins present in the airway surface fluid (ASF), the mucin-rich fluid covering the respiratory epithelium. These include larger
D M, Laube +4 more
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Antimicrobial peptides of vertebrates
Current Opinion in Immunology, 1998The past year brought several discoveries that focused attention on antimicrobial peptides on epithelial surfaces. The malfunction of these substances was implicated as a cause of airway infections in cystic fibrosis. Other highlights included new insights into the relative selectivity of antimicrobial peptides for microbial membranes, their primary ...
T, Ganz, R I, Lehrer
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Antimicrobial peptides in plants.
2010AbstractThis chapter provides an overview of plant antimicrobial peptides. It mainly focuses on one particular class of plant defence peptides, namely the cyclotides, which have been discovered over the last decade in plants from the Rubiaceae, Violaceae and Cucurbitaceae families.
Kaas, Quentin +3 more
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Antimicrobial Peptides of Lactoferrin
1994Lactoferrin was found to contain an antimicrobial sequence near its N-terminus which appears to function by a mechanism distinct from iron chelation. Antimicrobial peptides representing this domain were isolated following pepsin cleavage of human lactoferrin and bovine lactoferrin.
M, Tomita +3 more
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Cationic antimicrobial peptides – an update
Expert Opinion on Investigational Drugs, 2004Cationic antimicrobial peptides play a very important role in nature as a first line of defence against attack and damage. However, their application to the clinic has not been very encouraging to date. There are indications that the barriers to their success may now be eroding with companies developing peptides to be more stable, cost effective and ...
Lijuan, Zhang, Timothy J, Falla
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Overview on Plant Antimicrobial Peptides
Current Protein & Peptide Science, 2010Mechanisms related to biotic interactions, such as pathogen attack, herbivory and symbiosis are important challenges to higher plants and have been widely studied especially for breeding purposes. The present review focuses on a special category of defense molecules, the plant antimicrobial peptides, providing an overview of their main molecular ...
A. M. Benko Iseppon +6 more
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Descriptors for antimicrobial peptides
Expert Opinion on Drug Discovery, 2011A frightening increase in the number of isolated multidrug resistant bacterial strains linked to the decline in novel antimicrobial drugs entering the market is a great cause for concern. Cationic antimicrobial peptides (AMPs) have lately been introduced as a potential new class of antimicrobial drugs, and computational methods utilizing molecular ...
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Antimicrobial Peptides: The LPS Connection
2009An expanding body of evidence is rendering manifest that many cationic antimicrobial peptides are endowed with different properties and activities, well beyond their direct action on microbes. One of the most interesting and potentially important research avenue on the alternative use of antimicrobial peptides grounds on their affinity toward ...
GIULIANI A, PIRRI G, RINALDI, ANDREA
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The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent
Antibiotics, 2021Joerg Overhage
exaly