Results 51 to 60 of about 264,067 (270)

Bioengineering Lantibiotics for Therapeutic Success [PDF]

, 2015
peer-reviewedSeveral examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents are being discovered with increased frequency. Of the latter group,
Cotter, Paul D., Field, Des, Hill, Colin, Ross, R Paul   +3 more
core   +2 more sources

Peptide Self-Assembly Is Linked to Antibacterial, but Not Antifungal, Activity of Histatin 5 Derivatives

mSphere, 2020
The rise of multidrug-resistant pathogens has awakened interest in new drug candidates such as antimicrobial peptides and their derivatives. Recent work suggests that some antimicrobial peptides have the ability to self-assemble into ordered amyloid-like
Lee Schnaider, Alexander Rosenberg, Topaz Kreiser, Sofiya Kolusheva, Ehud Gazit, Judith Berman   +5 more
doaj   +1 more source

Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens

Microorganisms, 2021
According to the World Health Organization (WHO) the development of resistance against antibiotics by microbes is one of the most pressing health concerns.
Johannes Koehbach, Jurnorain Gani, Kai Hilpert, David J Craik   +3 more
doaj   +1 more source

Identification and Characterisation of the Antimicrobial Peptide, Phylloseptin-PT, from the Skin Secretion of Phyllomedusa tarsius, and Comparison of Activity with Designed, Cationicity-Enhanced Analogues and Diastereomers

Molecules, 2016
Antimicrobial peptides belonging to the phylloseptin family are mainly found in phyllomedusine frogs. These peptides not only possess potent antimicrobial activity but exhibit low toxicity against eukaryotic cells.
Yitian Gao, Di Wu, Xinping Xi, Yue Wu, Chengbang Ma, Mei Zhou, Lei Wang, Mu Yang, Tianbao Chen, Chris Shaw   +9 more
doaj   +1 more source

Effect of Antimicrobial Peptide from Marine Microorganism on the Storage Quality of Freshly Squeezed Cucumber Juice

Shipin gongye ke-ji, 2023
To investigate the effects of different concentrations of antimicrobial peptide from marine Bacillus subtilis on the quality changes of freshly squeezed cucumber juice during the storage period (5 d) at room temperature.
Luqi YAN, Minghui TAN, Kuntai LI
doaj   +1 more source

Forager bees (Apis mellifera) highly express immune and detoxification genes in tissues associated with nectar processing. [PDF]

, 2015
Pollinators, including honey bees, routinely encounter potentially harmful microorganisms and phytochemicals during foraging. However, the mechanisms by which honey bees manage these potential threats are poorly understood.
Johnson, Brian R, Mohamed, Abbas, Vannette, Rachel L   +2 more
core   +1 more source

Chain-end modifications and sequence arrangements of antimicrobial peptoids for mediating activity and nano-assembly [PDF]

, 2020
Poly(N-substituted glycine) “peptoids” are an interesting class of peptidomimics that can resist proteolysis and mimic naturally found antimicrobial peptides (AMPs), which exhibit wide spectrum activity against bacteria.
Castelletto, Valeria, Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Saxena, Varun, Sefcik, Jan, Seitsonen, Jani, Zimbitas, Georgina   +9 more
core   +2 more sources

Antimicrobial peptides

Upsala Journal of Medical Sciences, 2014
With increasing antibiotics resistance, there is an urgent need for novel infection therapeutics. Since antimicrobial peptides provide opportunities for this, identification and optimization of such peptides have attracted much interest during recent years.
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Impacts of Hydrophobic Mismatch on Antimicrobial Peptide Efficacy and Bilayer Permeabilization

Antibiotics, 2023
Antimicrobial resistance continues to be a major threat to world health, with the continued emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an attractive option for the development of novel antimicrobial compounds in part
Steven Meier, Zachary M. Ridgway, Angela L. Picciano, Gregory A. Caputo   +3 more
doaj   +1 more source