Results 51 to 60 of about 122,053 (250)

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Inhibitory activities of the synthetic antimicrobial peptides against cotton Verticillium dahliae

浙江大学学报. 农业与生命科学版, 2013
Verticillium wilt, caused by Verticillium dahliae (VD), is the most disastrous pathogen in cotton fungal diseases, which causes huge monetary losses by inducing vascular wilt and exists widely in China cotton planting area.
ZHAO Yijing, NI Mi, Noreen Bibi, WANG Xuede   +3 more
doaj   +1 more source

Discovering highly potent antimicrobial peptides with deep generative model HydrAMP

Nature Communications, 2023
Antimicrobial peptides emerge as compounds that can alleviate the global health hazard of antimicrobial resistance, prompting a need for novel computational approaches to peptide generation. Here, we propose HydrAMP, a conditional variational autoencoder
Paulina Szymczak, Marcin Możejko, Tomasz Grzegorzek, Radosław Jurczak, Marta Bauer, Damian Neubauer, Karol Sikora, Michał Michalski, Jacek Sroka, Piotr Setny, Wojciech Kamysz, Ewa Szczurek   +11 more
doaj   +1 more source

Bio‐Inspired Molecular Events in Poly(Ionic Liquids)

Advanced Functional Materials, EarlyView.
Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley   +1 more source

Peptide Stapling Applied to Antimicrobial Peptides

Antibiotics, 2023
Antimicrobial peptides (AMPs) are considered a promising therapeutic approach against multi-drug resistant microorganisms. Besides their advantages, there are limitations to be overcome so that these molecules can become market competitive. One of the biggest limitations is proteolytic susceptibility, which could be overcome by structural modifications
Ana Laura Pereira Lourenço, Thuanny Borba Rios, Állan Pires da Silva, Octávio Luiz Franco, Marcelo Henrique Soller Ramada   +4 more
openaire   +3 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Peptides and Peptidomimetics for Antimicrobial Drug Design

Pharmaceuticals, 2015
The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies.
Biljana Mojsoska, Håvard Jenssen
doaj   +1 more source

LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models

Advanced Functional Materials, EarlyView.
This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran, Diane C.A. Lima, Linda Sandblad, Madeleine Ramstedt, Thereza A. Soares, Stefan Salentinig   +5 more
wiley   +1 more source

Biocompatible but Antibacterial Mechanism of Graphene Oxide for Sustainable Antibiotics

Advanced Functional Materials, EarlyView.
Graphene oxide (GO) exhibits selective antibacterial activity through specific interactions between its oxygen functional groups and bacterial membrane phospholipid POPG, causing membrane destabilization while maintaining biocompatibility. Model membrane studies and infected wound models in mice and pigs demonstrate effective bacterial suppression and ...
Sujin Cha, Ju Yeon Chung, Seungju Yang, Seung Cheol Lee, Chan Woo Lee, Colin Wing‐Lok Cheng, Jun Beom Kim, Nam Jun Kim, Ayoung Park, Heewon Choi, Junpyo Sinn, Ralph Weissleder, Nicholas A. Kotov, Myungeun Seo, Hyun Jung Chung, Sang Ouk Kim   +15 more
wiley   +1 more source