Results 41 to 50 of about 248,677 (314)

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

mBio, 2020
Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics.
Elizabeth M. Grimsey, Chiara Fais, Robert L. Marshall, Vito Ricci, Maria Laura Ciusa, Jack W. Stone, Alasdair Ivens, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock   +10 more
doaj   +1 more source

Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model

Scientific Reports, 2021
Ceftolozane/tazobactam (C/T) has emerged as a potential agent for the treatment of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections.
María M. Montero, Sandra Domene-Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Eduardo Padilla, Núria Prim, Lorena Ferrer-Alapont, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

The Impact of Triclosan on the Spread of Antibiotic Resistance in the Environment [PDF]

, 2015
Triclosan (TCS) is a commonly used antimicrobial agent that enters wastewater treatment plants (WWTPs) and the environment. An estimated 1.1 × 105 to 4.2 × 105 kg of TCS are discharged from these WWTPs per year in the United States.
Carey, Daniel E., McNamara, Patrick J.
core   +3 more sources

Investigating the feasibility and potential of combining industry AMR monitoring systems: a comparison with WHO GLASS [version 2; peer review: 2 approved]

Wellcome Open Research
Background Efforts to estimate the global burden of antimicrobial resistance (AMR) have highlighted gaps in existing surveillance systems. Data gathered from hospital networks globally by pharmaceutical industries to monitor antibiotic efficacy in ...
Aleksandra Kovacevic, Eve Rahbé, Quentin J. Leclerc, Lulla Opatowski   +3 more
doaj   +1 more source

Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates

Microbiology Spectrum, 2021
Ceftazidime-avibactam (CZA) has emerged as a promising solution to the lack of new antibiotics against Pseudomonas aeruginosa infections. Data from in vitro assays of CZA combinations, however, are scarce. The objective of our study was to perform a time-
María M. Montero, Sandra Domene Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Inmaculada López Montesinos, Eduardo Padilla, Núria Prim, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]

, 2018
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D, Ferrell, Andrea, Hsiung, Andre, Humphries, Romney M, Kircher, Susan, Krause, Kevin M, Malherbe, Rianna   +6 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

AmpHGT: expanding prediction of antimicrobial activity in peptides containing non-canonical amino acids using multi-view constrained heterogeneous graph transformer

BMC Biology
Background Antimicrobial peptide (AMP) prediction has been extensively studied in recent years. However, many existing models do not fully leverage the intrinsic chemical structures of AMPs, such as atomic composition and sidechain group characteristics.
Yongcheng He, Xu Song, Hongping Wan, Xinghong Zhao   +3 more
doaj   +1 more source

Science-in-brief: Clinical highlights from BEVA Congress 2016 [PDF]

, 2017
No abstract ...
Chauché, C., Kennedy, R.
core   +1 more source

Antimicrobials: bacteraemia [PDF]

JAC-Antimicrobial Resistance, 2020
Graphical Abstract.
openaire   +2 more sources