Results 41 to 50 of about 22,860 (171)

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Peripheral Mononuclear Cell Mitochondrial Function Associates with T‐Cell Cytokines in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is the most common neurodegenerative movement disorder and one of the world's fastest‐growing neurological diseases. Although the exact causes of PD are unknown, mitochondrial dysfunction and inflammation may have significant roles in disease progression.
Fatima Afaar, Priscilla Youssef, Jasmin Galper, Michelle Chua, Glenda M. Halliday, Simon J.G. Lewis, Nicolas Dzamko   +6 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Suppression of rice blast and tomato late blight by Paraboeremia adianticola producing vulculic acid

Pest Management Science, EarlyView.
This study presents promising results for disease control efficacy using the culture filtrate of Paraboeremia adianticola SFC20150402‐M24 and its major active compound, vulculic acid, which affects mitochondrial respiration. Abstract BACKGROUND In the search for new natural resources with antifungal activity, the culture filtrate of the marine‐derive ...
Je‐Hyun Park, Jae Woo Han, Bomin Kim, Sang Un Park, Gyung Ja Choi, Hun Kim   +5 more
wiley   +1 more source

Immunotherapeutic targeting of aging‐associated isoDGR motif in chronic lung inflammation

Aging Cell, Volume 24, Issue 4, April 2025.
Accumulation of isoDGR‐damaged proteins in aged lung tissues leads to macrophage infiltration and chronic inflammation. Anti‐isoDGR antibodies treatment clears isoDGR proteins and reduces inflammation and lung damage. Abstract Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age‐related chronic diseases. Since this
Pazhanichamy Kalailingam, SoFong Cam Ngan, Ranjith Iyappan, Afra Nehchiri, Khalilatul‐Hanisah Mohd‐Kahliab, Benjamin Sian Teck Lee, Bhargy Sharma, Radek Machan, Sint Thida Bo, Emma S. Chambers, Val A. Fajardo, Rebecca E. K. Macpherson, Jian Liu, Panagiota Klentrou, Evangelia Litsa Tsiani, Kah Leong Lim, I. Hsin Su, Yong‐Gui Gao, A. Mark Richar, Raj N. Kalaria, Christopher P. Chen, Cynthia Balion, Dominique de Kleijn, Neil E. McCarthy, Siu Kwan Sze   +24 more
wiley   +1 more source

Nuclear respiratory factor‐1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells

Aging Cell, Volume 24, Issue 4, April 2025.
Mitochondrial dysfunction is associated with senescence, the latter proving detrimental to mesenchymal stem cell (MSC)‐based strategies. We induced the expression of nuclear respiratory factor‐1 (NRF1), a driver of mitochondrial biogenesis, to metabolically potentiate MSCs and stave off senescence.
Hyunho Lee, Matteo Massaro, Nourhan Abdelfattah, Gherardo Baudo, Haoran Liu, Kyuson Yun, Elvin Blanco   +6 more
wiley   +1 more source

ABSOLUTE CONFIGURATIONS OF ANTIMYCIN LAGTONES AND ANTIMYCIN A

The Journal of Antibiotics, 1972
Shimpei Aburaki, Sumio Umezawa, Mitsuhiro Kinoshita   +2 more
openaire   +4 more sources

The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders

Aging Cell, EarlyView.
Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim, Hye Sun Go, Eun Jae Jeon, Thi Quynh Trang Nguyen, Da Yeon Kim, Hansung Park, Hyo‐Ji Eom, Sung Young Kim, Sang Chul Park, Kyung A Cho   +9 more
wiley   +1 more source

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, EarlyView.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source