Results 91 to 100 of about 25,615 (222)

Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity [PDF]

, 2017
A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared.
Abrahams, Aeluri, Ballell, Batt, Beckmann, Cherney, Collins, Comer, Comer, Connors, Corte, Cox, Dinsmore, Driggers, Ertl, Franzblau, Giordanetto, Grossmann, Hong, Irwin, Kitsiou, Kopp, Kuhn, Lennard, Lipkus, Marcaurelle, Morton, Nie, Over, Pye, Stanton, Tao, Taylor   +32 more
core   +2 more sources

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate and Its In Silico Prediction of the Toxicity

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
In vivo and in silico toxicological effects of Calea phyllolepis extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate. ABSTRACT Medicinal plants are traditionally used in folk medicine. Still, there is a misconception about the safety/efficacy of natural treatments, which results in few studies on the toxic, genotoxic, and mutagenic potential of ...
Suele Bierhals Vencato, Guilherme Borsoi, Cleverson Feistel, Mariele Feiffer Charão, Angélica Rocha Joaquim, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz   +6 more
wiley   +1 more source

Handling the Hurdles on the Way to Anti-tuberculosis Drug Development

Frontiers in Chemistry, 2020
The global epidemic of tuberculosis (TB) imposes a sustained epidemiologic vigilance and investments in research by governments. Mycobacterium tuberculosis, the main causative agent of TB in human beings, is a very successful pathogen, being the main ...
Pedro F. Dalberto, Eduardo V. de Souza, Bruno L. Abbadi, Christiano E. Neves, Raoní S. Rambo, Alessandro S. Ramos, Fernanda S. Macchi, Pablo Machado, Cristiano V. Bizarro, Luiz A. Basso   +9 more
doaj   +1 more source

A Review of the Phytochemistry, Molecular Docking, Pharmacology, Toxicology, Ethnopharmacology, Botany, and Clinical Studies of Maytenus senegalensis (Lam.) Excell

Biomolecules
Maytenus senegalensis (Lam.) Excell, also known as Gymnosporia senegalensis (Lam.) Loes, is distributed particularly in savannah regions of tropical Africa.
Thanyani Emelton Ramadwa, Stephen Meddows-Taylor   +1 more
doaj   +1 more source

In Vitro Synergy of Biochanin A and Ciprofloxacin against Clinical Isolates of Staphylococcus aureus

Molecules, 2011
Many clinical isolates of Staphylococcus aureus (S. aureus) are resistant to numerous antimicrobials, including the fluoroquinolones (FQs). Flavonoids such as biochanin A (BCA) are compounds that are naturally present in fruits, vegetables, and plant ...
Ming-Yuan Liu, Lei Li, Lu Yu, Li-Hui Liu, Feng-Ge Shen, Ming-Xun Xing, Xiu-Ping Wu, Na Guo, Jun-Chao Liang, Xue-Lin Wang, Zhao-Hui Li, Wei Wang, Guoxing Liu   +12 more
doaj   +1 more source

In vitro antibacterial activities of selected TB drugs in the presence of clay minerals against multidrug-resistant strain of Mycobacterium smegmatis

Cogent Engineering, 2020
Healing clay is a rich source of diverse minerals. The relevance of these indigenous minerals in the improvement of antibiotic chemotherapy against prevailing bacterial pathogens is yet to be thoroughly explored.
Patrick K. Arthur, Vincent Amarh, Ethel J. S. Blessie, Rebecca Yeboah, Benjamin W. Kankpeyeng, Samuel N. Nkumbaan, Elvis K Tiburu   +6 more
doaj   +1 more source

Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]

, 2018
Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core   +1 more source

Antimycobacterial activity of lichen substances

Phytomedicine, 2010
We describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity.
Honda, N. K., Pavan, Fernando Rogério, Coelho, R. G., de Andrade Leite, S. R., Micheletti, A. C., Lopes, T. I. B., Misutsu, M. Y., Beatriz, A., Brum, R. L., Leite, Clarice Queico Fujimura   +9 more
openaire   +3 more sources

The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity

Toxins, 2019
Californiconus californicus, previously named Conus californicus, has always been considered a unique species within cone snails, because of its molecular, toxicological and morphological singularities; including the wide range of its diet, since it is ...
Johanna Bernáldez-Sarabia, Andrea Figueroa-Montiel, Salvador Dueñas, Karla Cervantes-Luévano, Jesús A. Beltrán, Ernesto Ortiz, Samanta Jiménez, Lourival D. Possani, Jorge F. Paniagua-Solís, Jorge Gonzalez-Canudas, Alexei Licea-Navarro   +10 more
doaj   +1 more source

"In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosis [PDF]

, 2006
Crohn's disease, a human disease similar to paratuberculosis in animals is the most painful and devastating disease that may involve infection with M. avium subsp.
Ahmed, Niyaz, Cannas, Sara, Molicotti, Paola, Ortu, Silvia, Sechi, Leonardo Antonio, Zanetti, Stefania Anna Lucia   +5 more
core