Results 71 to 80 of about 25,615 (222)

Small molecule and fragment-based phenotypic screening for novel building blocks with antimycobacterial activity [PDF]

Exploration of Drug Science
Aim: To design, synthesize, and test small molecules and fragment-based compounds with putative selective anti-mycobacterial activity. Methods: Standard chemosynthetic processes were used to synthesize 42 compounds.
Monika I. Konaklieva, Kriti Arora, Helena I. M. Boshoff, Balbina J. Plotkin   +3 more
doaj   +1 more source

Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-dimethylaminomethyl)phenyl)quinoline Derived Antitubercular Lead Compounds [PDF]

, 2016
Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study
Cui, HC, Fu, LF, He, CH, Meier, TK, Preiss, LP, Wang, BW, Wen, HW, Yin, DY, Zhang, XZ   +8 more
core   +1 more source

Multi‐Scale Rational Design and Synergistic Strategies of Nanozymes for Targeting Drug‐Resistant Pathogens

Rare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He, Flomo Peter Gbonyea, Zhen‐Lian Han, Xiao‐Bo Zheng, Meng‐Ru Li, Meng‐Di Liang, Jing‐Qi Feng, Ze‐Chao Zhuang, Yu‐Chao Gu, Li‐Gang Wang, Shu‐Fang Ji, Pei Liu   +11 more
wiley   +1 more source

Antimicrobial Activity of Solanum torvum Crude Extracts against Important Mycobacterial Strains

International Journal of Mycobacteriology
Background: Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) complex remains a leading cause of morbidity and mortality worldwide. The zoonotic infectious condition represents a never-ending challenge for which drug discovery efforts are ...
Joseph Mwanzia Nguta
doaj   +1 more source

Synthesis and Antibacterial Evaluation of a New Series of <em>N</em>-Alkyl-2-alkynyl/(<em>E</em>)-alkenyl-4-(1<em>H</em>)-quinolones

Molecules, 2012
To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some <em>N</em>-alkyl-4-(1<em>H</em>)-quinolones bearing position 2 alkynyls with various chain ...
Abraham Wube, Juan-David Guzman, Antje Hüfner, Christina Hochfellner, Martina Blunder, Rudolf Bauer, Simon Gibbons, Sanjib Bhakta, Franz Bucar   +8 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Thiazolidinone-Containing Quinoxaline-1,4-di-N-oxides as Antimycobacterial and Antifungal Agents

Frontiers in Chemistry, 2020
Tuberculosis and fungal infections can pose serious threats to human health. In order to find novel antimicrobial agents, 26 novel quinoxaline-1,4-di-N-oxides containing a thiazolidinone moiety were designed and synthesized, and their antimycobacterial ...
Heying Zhang, Heying Zhang, Jie Zhang, Jie Zhang, Wei Qu, Shuyu Xie, Lingli Huang, Lingli Huang, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zhenli Liu, Yuanhu Pan, Yuanhu Pan, Zonghui Yuan, Zonghui Yuan   +15 more
doaj   +1 more source

Antimycobacterial Activity of Salicylanilide Benzenesulfonates [PDF]

Molecules, 2012
A series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, 1H-NMR and 13C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii.
Jiřina Stolaříková, Jarmila Vinšová, Martin Krátký, Nabila Guisado Rodriguez   +3 more
openaire   +3 more sources

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Antibiotics, 2020
Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases.
Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam   +2 more
doaj   +1 more source

Eugenol‐Based Thiazole Derivatives Inhibit the MepA Efflux Pump in Staphylcoccus aureus

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
ABSTRACT Multidrug resistant (MDR) bacteria are considered critical priority pathogens by the World Health Organization (WHO). Considering the relevance of antibacterial drug development in this scenario, the present research study aimed to evaluate the antibacterial activity of eugenol‐based thiazole derivatives and analyze their potential to inhibit ...
Ray Silva de Almeida, Laís Regina dos Santos Folquitto, Priscilla Ramos Freitas, Ana Carolina Justino de Araujo, Saulo Relison Tintino, Jaime Ribeiro‐Filho, Cícera Datiane de Morais Oliveira‐Tintino, Gustavo Marinho Miranda, Ivaldo Francisco da Silva Junior, Diogo Teixeira Carvalho, Thiago Belarmino de Souza, Danielle Ferreira Dias, Carolina Bandeira Domiciano, Henrique Douglas Melo Coutinho   +13 more
wiley   +1 more source