Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design [PDF]
, 2009 Pyrazinoic acid esters have been synthesized as prodrugs of pyrazinoic acid. In the literature, its preparation is reported through the reaction of pyrazinoyl chloride with alcohols and the reaction with DCC/DMAP.
FELLI, Veni Maria Andres +1 more
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Sciences of PhytochemistryStructural features of the triterpenoid skeleton that are necessary for antimycobacterial activity are not well understood. Following the isolation of the triterpenoids ergosterol-5,8-endoperoxide, 6β-hydroxykulactone, 12β-hydroxykulactone, (24R)-24,25 ...
Mohamed Said Rajab
doaj +1 more source
Type I interferons in tuberculosis: Foe and occasionally friend [PDF]
, 2018 Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K +3 more
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BMC Complementary and Alternative Medicine, 2019 Background Tuberculosis is a deadly disease caused by Mycobacterium species. The use of medicinal plants is an ancient global practice for the treatment and prevention of diverse ailments including tuberculosis.
Abimbola O. Aro +5 more
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Identifying Novel Inhibitors of RpFabG in Typhus-inducing Rickettsia prowazekii [PDF]
, 2019 Epidemic typhus is a rickettsial disease that is contracted via ticks and lice found on the flying squirrel. The disease is caused by Rickettsia prowazekii, an intracellular, gram-negative coccobacillus.
Panatpur, Aparna
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Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity
Molecules, 2000 A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid ...
Zbynek Svoboda +7 more
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"In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosis [PDF]
, 2006 Crohn's disease, a human disease similar to paratuberculosis in animals is the most painful and devastating disease that may involve infection with M. avium subsp.
Ahmed, Niyaz +5 more
core
A Novel Diarylquinoline for Multidrug-Resistant Tuberculosis [PDF]
, 2014 Objective: To review the chemistry, pharmacology, microbiology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, dosage, and administration of bedaquiline, a novel oral diarylquinoline antimycobacterial agent approved by the Food and Drug ...
Chahine, Elias B. +2 more
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Newer antimycobacterial drugs and their role in the treatment of tuberculosis patients [PDF]
, 1994 The main lesion in pulmonary tuberculosis, the pulmonary cavity, contains a large number of mycobacteria (about 108 colony forming units). Of these, a large bacillary population is located in the thin liquid caseous layer that covers the inner part ...
Paramasivan, C N
core
2-Substituted agelasine analogs : synthesis and biological activity, and structure and reactivity of synthetic intermediates [PDF]
, 2011 2-Substituted N-methoxy-9-methyl-9H-purin-6-amines were synthesized either from their corresponding 6-chloro-9-methyl-9H-purines or 2-chloro-N-methoxy-9-methyl- 9H-purin-6-amine.
Bohlin, Lars +8 more
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