Results 91 to 100 of about 19,828 (226)

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Antimycobacterial Natural Products from Endophytes of the Medicinal Plant

Natural Product Communications, 2015
Antimycobacterial extracts of a Penicillium sp. (isolate HL4-159-41B) and a Coniothyrium sp. (isolate HL6-097-027B) isolated from the rhizomes of the Canadian medicinal plant Aralia nudicaulis were found to contain palitantin (1) and botrallin (2 ...
Haoxin Li, Brandon Doucet, Andrew J. Flewelling, Stephanie Jean, Duncan Webster, Gilles A. Robichaud, John A. Johnson, Christopher A. Gray   +7 more
doaj   +1 more source

Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity [PDF]

, 2017
A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared.
Abrahams, Aeluri, Ballell, Batt, Beckmann, Cherney, Collins, Comer, Comer, Connors, Corte, Cox, Dinsmore, Driggers, Ertl, Franzblau, Giordanetto, Grossmann, Hong, Irwin, Kitsiou, Kopp, Kuhn, Lennard, Lipkus, Marcaurelle, Morton, Nie, Over, Pye, Stanton, Tao, Taylor   +32 more
core   +2 more sources

Should TNF inhibitors be avoided in psoriasis patients with latent tuberculosis?

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Fabià Torres‐Betato, Lluís Puig
wiley   +1 more source

Alternative Approaches and Plant‐Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Due to limited access to, and the high cost of conventional veterinary services, Batswana communities often rely on ethnoveterinary practices for livestock health management. This review provides an in‐depth analysis on the ethnoveterinary uses, biological properties and safety assessment of plants utilised in livestock husbandry. A systematic
Tswelelopele G. Mpolokeng, Ndzalama Shikwambana, Mompati V. Chakale, John A. Asong, Lyndy J. McGaw, Stephen O. Amoo, Nqobile A. Masondo, Adeyemi O. Aremu   +7 more
wiley   +1 more source

Dynamics of cytokine profile indexes in children with first diagnosed pulmonary tuberculosis in the course of antimycobacterial therapy

Zaporožskij Medicinskij Žurnal, 2018
Antimycobacterial therapy is the main method of tuberculosis treatment. But some antimycobacterial medications have an unfavorable influence on the immune system and this fact significantly decreases efficiency of treatment and requires an additional ...
O. M. Raznatovska, Yu. V. Mironchuk
doaj   +1 more source

In-silico and in-vitro assessments of some fabaceae, rhamnaceae, apocynaceae, and anacardiaceae species against Mycobacterium tuberculosis H37Rv and triple-negative breast cancer cells

BMC Complementary Medicine and Therapies, 2023
Medicinal plants play a huge role in the treatment of various diseases in the Limpopo province (South Africa). Traditionally, concoctions used for treating tuberculosis and cancer are sometimes prepared from plant parts naturally occurring in the region,
Kudakwashe Nyambo, Francis Adu-Amankwaah, Kudzanai Ian Tapfuma, Lucinda Baatjies, Lauren Julius, Liezel Smith, Mkhuseli Ngxande, Krishna Govender, Lawrence Mabasa, Afsatou Traore, Maano Valerie Masiphephethu, Idah Sithole Niang, Vuyo Mavumengwana   +12 more
doaj   +1 more source

Comparative in-vitro activity of fleroxacin and other 6-fluoroquinolones against mycobacteria [PDF]

, 2017
The susceptibility of 11 clinical isolates of Mycobacterium tuberculosis, 3 M. kansasii,3 M. xenopi, 2 M.scrofulaceum, 2 M. marinum, 2 M. malmoense to fleroxacin,ciprofloxacin, norfloxacin, rifampicin, isoniazid, ethambutol, and streptomycin was ...
Hohl, Peter, Kafader, Felicitas M., Salfinger, Max   +2 more
core  

Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines; imidazopyridines, pyrrolopyridines, benzimidazoles and indoles [PDF]

, 2011
6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tuberculosis (Mtb) in vitro. Analogs modified in the six-membered ring (imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles) were synthesized ...
Charnock, Colin, Franzblau, Scott, Gundersen, Lise-Lotte, Khoje, Abhijit Datta, Wan, Baojie   +4 more
core   +1 more source

Tabernaemontana catharinensis: A Source of Indole Alkaloids With Potential Activity as Chemotherapeutic Agents

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the antitumor activity of fractions rich in indole alkaloids extracted from the leaves of the species Tabernaemontana catharinensis. The chemical composition was analyzed using high‐resolution mass spectrometry (HRMS), which identified nine known indole alkaloids, including voacangine, voacangine hydroxyindolenine,
Ana Júlia Gomes Donada, Rafael Freitas Corá, Bianca Canci, Mariana Roesch‐Ely, Pauline Fagundes Rosales, Sidnei Moura   +5 more
wiley   +1 more source