Results 91 to 100 of about 11,373 (215)

Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity [PDF]

, 2019
We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of exploring newer chemical ...
Vasan K. Sambandamurthy (440161), Meenakshi Mallya (3715594), Khisi Mdluli (1779898), Radha Shandil (1786687), Claire Sadler (1734118), Jyothi Mahadevaswamy (1786696), Christopher Cooper (277072), Ruben Tommasi (1271391), Pravin S. Iyer (1751494), M. Sreenivasaiah (7438637), Sreevalli Sharma (1668004), Manoranjan Panda (1684504), Anisha Ambady (780611), Scott Butler (1779880), Manjunatha M. R (7438634), Pravin S. Shirude (1267143), Ashwini Narayan (1751479), Vasanthi Ramachandran (1751488), Supreeth Guptha (1734121), Shridhar Narayanan (456463), Monalisa Chatterji (1751476), Vijender Panduga (1764655), Naveen Kumar (66313)   +22 more
core   +1 more source

Antimycobacterial activity of 2-methyl-adenosine [PDF]

Journal of Antimicrobial Chemotherapy, 2003
The aims of this study were to assess the in vitro activity of 2-methyl-adenosine against Mycobacterium tuberculosis and evaluate, and to intracellular efficacy, and to evaluate its effectiveness against M. tuberculosis in a persistent state model and examine its potential mechanism of action.In vitro activity was determined by means of a colorimetric ...
Esther W, Barrow, Louise, Westbrook, Namita, Bansal, William J, Suling, Joseph A, Maddry, William B, Parker, William W, Barrow   +6 more
openaire   +2 more sources

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source

Dynamics of cytokine profile indexes in children with first diagnosed pulmonary tuberculosis in the course of antimycobacterial therapy

Zaporožskij Medicinskij Žurnal, 2018
Antimycobacterial therapy is the main method of tuberculosis treatment. But some antimycobacterial medications have an unfavorable influence on the immune system and this fact significantly decreases efficiency of treatment and requires an additional ...
O. M. Raznatovska, Yu. V. Mironchuk
doaj   +1 more source

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, Venkata Lakshamana Sagar Dantinapalli   +5 more
wiley   +1 more source

Antimycobacterial activity of diospyrin and its derivatives against Mycobacterium aurum [PDF]

, 2015
The objective of this study was to determine the antimycobacterial activity of diospyrin (D1) and four of its derivatives (D2, D5, D7 and D17) against the non-pathogenic Mycobacterium aurum.
Banasri Hazra, Stanley Mukanganyama, Elaine Chirisa and
core   +1 more source

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against Mycobacterium tuberculosis: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam, Md. Zahid Hasan, Md. Touki Tahamid Tusar, Md. Yeamin Hossain, Md. Motaher Hossain, Md. Abdulla Al Jubayed, Md. Jubaer‐Al‐Abedin, Sheikh Soikot, Shanzida Akther, Jahid Bhuyian, Hafizur Rahman Gazi, B. M. Mahmudul Hasan, Md. Shofiul Azam, Md. Enamul Haque, Abdullah‐Al‐Jubayer, Md. Faruk Hasan, F. M. Ali Haydar, Md. Khalekuzzaman, Md. Torequl Islam, Sohel Hasan   +19 more
wiley   +1 more source

Antimycobacterial Activity and Brine Shrimp Toxicity of Wild Mushrooms Used by Communities in Southern Tanzania [PDF]

Research Journal of Pharmacognosy
Background and objectives: Several wild mushroom species occur in southern Tanzania and are used as food by the local tribes. Experience shows that some of them could contain phytochemical compounds with therapeutic potential for treating various ...
Michael Qwarse*, Mainen Julius Moshi, Matobola Joel Mihale, Alphonce Ignace Marealle, Ramadhani Selemani Omari Nondo, Joseph Sempombe, Veronica Mugoyela   +6 more
doaj   +1 more source

Diffuse Large B‐Cell Lymphoma With Pulmonary and Gastric Involvement Mimicking Nontuberculous Mycobacterial Lung Disease

Respirology Case Reports, Volume 14, Issue 5, May 2026.
An 81‐year‐old man presented with multiple bilateral pulmonary nodules and detection of Mycobacterium intracellulare, initially suggesting nontuberculous mycobacterial lung disease. However, heterogeneous radiological changes and progressive enlargement of selected nodules led to surgical lung biopsy, which revealed diffuse large B‐cell lymphoma with ...
Kosuke Masuda, Kazuhiro Asada, Yuu Saitoh, Makoto Suzuki, Emi Fukasawa, Yumi Fujita, Kosuke Suzuki, Sho Murai, Daisuke Akahori, Mika Saigusa, Taisuke Akamatsu, Akito Yamamoto, Satoru Morita, Toshihiro Shirai   +13 more
wiley   +1 more source

Antimycobacterial Activity of Cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) Model [PDF]

, 2018
The purpose of the study was to evaluate the antimycobacterial activity and the possible action mode of cinnamon bark essential oil and its main constituent—cinnamaldehyde—against the Mycobacterium tuberculosis ATCC 25177 strain ...
Joanna Golus, Agata Przekora, Grazyna Ginalska, Elwira Sieniawska, Rafal Sawicki, Agnieszka Ludwiczuk   +5 more
core   +1 more source