Results 81 to 90 of about 8,621 (178)

[Antimycobacterial activities of a new quinolone, sparfloxacin].

Kekkaku : [Tuberculosis], 1991
Sparfloxacin (SPFX), a new quinolone, was studied its in vitro and in vivo activities against various mycobacteria, especially Mycobacterium intracellulare. SPFX exhibited a potent in vitro activity against M. tuberculosis, M.kansasii and M.fortuitum with MIC90 values of 0.2, 6.25 and 1.6 micrograms/ml, respectively, and the potency of SPFX was higher ...
TOMIOKA, Haruaki, SATO, Katsumasa, SAITO, Hajime   +2 more
openaire   +2 more sources

Antimycobacterial Natural Products from Endophytes of the Medicinal Plant

Natural Product Communications, 2015
Antimycobacterial extracts of a Penicillium sp. (isolate HL4-159-41B) and a Coniothyrium sp. (isolate HL6-097-027B) isolated from the rhizomes of the Canadian medicinal plant Aralia nudicaulis were found to contain palitantin (1) and botrallin (2 ...
Haoxin Li, Brandon Doucet, Andrew J. Flewelling, Stephanie Jean, Duncan Webster, Gilles A. Robichaud, John A. Johnson, Christopher A. Gray   +7 more
doaj   +1 more source

Immunological and microbiological activity of Davilla elliptica St. Hill. (Dilleniaceae) against Mycobacterium tuberculosis

Memorias do Instituto Oswaldo Cruz, 2007
Mycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The immunological activity of Davilla elliptica chloroform extract (DECE) was evaluated
Flávia Cristine Mascia Lopes, Marisa Campos Polesi Placeres, Cleso Mendonça Jordão Junior, Célio Takashi Higuchi, Daniel Rinaldo, Wagner Vilegas, Clarice Queico Fujimura Leite, Iracilda Zeppone Carlos   +7 more
doaj   +1 more source

In Silico Structure-Activity Study of Selected Triterpenoids as Potential Inhibitors of Mycolic Acid Transporter of Mycobacterial MmpL3 Receptor Protein

Sciences of Phytochemistry
Structural features of the triterpenoid skeleton that are necessary for antimycobacterial activity are not well understood. Following the isolation of the triterpenoids ergosterol-5,8-endoperoxide, 6β-hydroxykulactone, 12β-hydroxykulactone, (24R)-24,25 ...
Mohamed Said Rajab
doaj   +1 more source

Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity

Molecules, 2000
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid ...
Zbynek Svoboda, Jiri Janota, Milan Slosarek, Zelmira Odlerova, Katarina Kralova, Jiri Kunes, Karel Waisser, Lenka Kubicova   +7 more
doaj   +1 more source

Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity

BMC Complementary and Alternative Medicine, 2019
Background Tuberculosis is a deadly disease caused by Mycobacterium species. The use of medicinal plants is an ancient global practice for the treatment and prevention of diverse ailments including tuberculosis.
Abimbola O. Aro, Jean P. Dzoyem, Maurice D. Awouafack, Mamoalosi A. Selepe, Jacobus N. Eloff, Lyndy J. McGaw   +5 more
doaj   +1 more source

Antimycobacterial activity of lichen metabolites in vitro

European Journal of Pharmaceutical Sciences, 1998
Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC ...
K, Ingólfsdóttir, G A, Chung, V G, Skúlason, S R, Gissurarson, M, Vilhelmsdóttir   +4 more
openaire   +2 more sources

Organ-Specific Distribution of Antimycobacterial Neolignans in Piper rivinoides and UHPLC-HRMS/MS Analysis of Its Extracts

Molecules
This multidisciplinary study investigates Piper rivinoides, a Brazilian medicinal species, focusing on its chemical composition and antimycobacterial potential.
Jéssica Sales Felisberto, Thayssa Ferreira Fagundes, Lorraynne Oliveira-Souza, Bruno Henrique Gomes de Souza, Daniel Machado de Brito, Jeferson Adriano Assunção, Samik Lourenço Massau, Marlon H. de Araújo, Michelle Frazão Muzitano, Sanderson Dias Calixto, Thatiana Lopes Biá Ventura Simão, Andre Mesquita Marques, Ygor Jessé Ramos, Davyson de Lima Moreira   +13 more
doaj   +1 more source

ANTIMYCOBACTERIAL AND CYTOTOXIC PERFORMANCE OF THE TRIAZOLE COMPOUND 177 IN FREE AND NANOENCAPSULATED FORMS AGAINST MYCOBACTERIUM TUBERCULOSIS

Brazilian Journal of Infectious Diseases
Introduction/Objectives: The development of new bioactive compounds is a promising strategy against tuberculosis (TB), a disease caused mainly by Mycobacterium tuberculosis (Mtb).
Fábio Rocha Formiga, Giovanna Gabriela Pedroza Rodrigues, Luanna de Ângelis Correia de Sousa, Douglas Dourado Oliveira, Ronaldo Nascimento de Oliveira, João Paulo de Lucena Laet, Romario Martins Araujo, Larissa Pereira Dantas da Silva, Danielle Martiniano da Silva Rodrigues, Renata Inglez de Souza Tejo, Josefa Nayara dos Santos Nascimento, Isabella Macário Ferro Cavalcanti, Lílian Maria Lapa Montenegro   +12 more
doaj   +1 more source

Exploring Antimycobacterial Potential: Safety Evaluation and Active Compound Isolation from Gymnopilus junonius

Antibiotics
Background/Objectives: Tuberculosis remains a major public health crisis, and it is imperative to search for new antimycobacterial drugs. Natural products, including medicinal macrofungi, have been used as sources for the discovery of pharmaceuticals ...
Jenske Didloff, Gerhardt J. Boukes, Mutenta N. Nyambe, Denzil R. Beukes, Mookho S. Lerata, Velile Vilane, Michael Lee, Sharlene Govender, Maryna van de Venter   +8 more
doaj   +1 more source