Results 151 to 160 of about 8,621 (178)

Phytochemistry and antimycobacterial activity of Chlorophytum inornatum

Phytochemistry, 2006
In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as
O’Donnell, Gemma, Bucar, Franz, Gibbons, Simon   +2 more
openaire   +3 more sources

A new amidrazone derivative with antimycobacterial activity

Acta Crystallographica Section C Crystal Structure Communications, 2000
Of a series of pyridine-2-carboxamidrazone derivatives with activity against mycobacteria, the N(1)-[4-(1,1-dimethylpropyl)benzylidene] derivative reported here, C(18)H(22)N(4), is one of the most active. The predicted E isomer about the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the ...
D C, Billington, P R, Lowe, D L, Rathbone, C H, Schwalbe   +3 more
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Synthesis of Imidazole Derivatives with Antimycobacterial Activity

Archiv der Pharmazie, 2010
Abstract4‐Substituted 1‐(p‐methoxybenzyl)imidazoles were designed and synthesized in order to mimic parts of the structure of highly potent antimycobacterial 6‐aryl‐9‐(p‐methoxybenzyl)purines. 4‐Haloimidazoles were subjected to Pd‐catalyzed cross‐coupling in order to introduce a (hetero)aryl group, or they were converted to Grignard reagents and ...
Pedro O, Miranda, Lise-Lotte, Gundersen
openaire   +2 more sources

New S-benzylisothiosemicarbazones with antimycobacterial activity

Folia Microbiologica, 2011
Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial ...
E, Petrlíková, K, Waisser, L, Heinisch, J, Stolaříková   +3 more
openaire   +2 more sources

Investigation of the Antimycobacterial Activity of 8-Hydroxyquinolines

Medicinal Chemistry, 2015
A series of styrylquinolines and quinolineamides based on the 8-hydroxyquinoline moiety were investigated as potential antimycobacterial agents. The lipophilicity of the compounds was measured using RP-HPLC and the tests of their activity against Mycobacterium kansasii, the M. avium complex, M. smegmatis, M. abscessus, M. tuberculosis and M.
Wioleta, Cieslik, Ewelina, Spaczynska, Katarzyna, Malarz, Dominik, Tabak, Eoghan, Nevin, Jim, O'Mahony, Aidan, Coffey, Anna, Mrozek-Wilczkiewicz, Josef, Jampilek, Robert, Musiol   +9 more
openaire   +2 more sources

Synthesis and antimycobacterial activity of nitroxanthones. 2nd communication: antimycobacterial activity.

Arzneimittel-Forschung, 1997
The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise interpretation by means of the bacterial growth kinetics method.
W G, Ibrom, K J, Schaper, A W, Frahm
openaire   +1 more source

Evaluation of antimycobacterial activity of a sulphonamide derivative

Tuberculosis, 2013
Mycobacterial infections including Mycobacterium tuberculosis have been increasing globally. The additional prevalence of multidrug-resistant (MDR-TB) strains and extensively drug-resistant tuberculosis (XDR-TB) stimulate an urgent need for the development of new drugs for the treatment of mycobacterial infections.
Vanessa Albertina, Agertt, Lenice Lorenço, Marques, Pauline Cordenonsi, Bonez, Tanise Vendruscolo, Dalmolin, Gelson Noe, Manzoni de Oliveira, Marli Matiko Anraku, de Campos   +5 more
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Highly active antimycobacterial derivatives of benzoxazine

Bioorganic & Medicinal Chemistry, 2010
New 3-(4-alkylphenyl)-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-(4-alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dithiones were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii.
Eva, Petrlíková, Karel, Waisser, Hana, Divišová, Petra, Husáková, Petra, Vrabcová, Jiří, Kuneš, Karel, Kolář, Jiřina, Stolaříková   +7 more
openaire   +2 more sources

Antimycobacterial Activity of Rifampicin

2015
M, Lucchesi, P, Mancini
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The Antimycobacterial Activity of Capreomycin

2015
openaire   +2 more sources