Results 181 to 190 of about 11,373 (215)

New Agents with Antimycobacterial Activity

Archiv der Pharmazie, 2005
AbstractIn this paper, we report that a series of structurally simple a‐halogenoacetamides (1–8) show potent and excellent antimycobacterial activities against drug‐sensitive Mycobacterium tuberculosis H37Rv and drug‐resistant M. avium.
José, Marco-Contelles, Elena, Gómez-Sánchez   +1 more
openaire   +2 more sources

Antimycobacterial activity of diphenylpyraline derivatives

European Journal of Medicinal Chemistry, 2008
2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy. Their activity against Mycobacterium tuberculosis H(37)Rv as well as their cytotoxicity against human cells (HEK ...
Robert, Weis, Johanna, Faist, Ulrike, di Vora, Klaus, Schweiger, Barbara, Brandner, Andreas J, Kungl, Werner, Seebacher   +6 more
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Antimycobacterial Activities of Oxazolidinones: A Review

Infectious Disorders - Drug Targets, 2006
Oxazolidinones are a new class of totally synthetic antibacterial agents with wide spectrum of activity against a variety of clinically significant susceptible and resistant bacteria. These compounds have been shown to inhibit translation at the initiation phase of protein synthesis.
R, Sood, T, Bhadauriya, M, Rao, R, Gautam, S, Malhotra, T K, Barman, D J, Upadhyay, A, Rattan   +7 more
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Substituted Xanthones as Antimycobacterial Agents, Part 2: Antimycobacterial Activity

Archiv der Pharmazie, 1998
A series of substituted xanthones was tested for their activity against four mycobacterial strains (Mycobacterium tuberculosis, M. avium, M. lufu, M. smegmatis) by determination of the minimum inhibitory concentrations (MIC values). For the most active compounds, supplementary characterisation was performed by bacterial growth kinetics, which allows a ...
Pickert, Martina, Schaper, Klaus Jürgen, Frahm, August Wilhelm   +2 more
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Antimycobacterial Activity of 1‐Substituted Indolizines

Archiv der Pharmazie, 2003
AbstractIndolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H37Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an α‐hydroxybenzyl substituent in the indolizine 1‐position.
Lise-Lotte, Gundersen, Ayele H, Negussie, Frode, Rise, Ole Benny, ØStby   +3 more
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Antimycobacterial activity of ionic fullerene derivatives

Bioorganic & Medicinal Chemistry Letters, 2000
Positively charged fullerene derivatives, moderately soluble in water:DMSO 9:1, have been tested using three strains of Mycobacterium spp. Some compounds inhibit the growth of Mycobacterium tuberculosis, a human clinical isolate, particularly virulent and resistant, at doses as low as 5 microg/mL.
BOSI, Susanna, DA ROS, TATIANA, S. CASTELLANO, BANFI, ELENA, PRATO, MAURIZIO   +4 more
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Rapid measurement of antimycobacterial drug activity

Research in Microbiology, 1996
68024
Gordon, S, Houldsworth, S, Roberts, IS, Andrew, PW, Duncan, K   +4 more
openaire   +3 more sources

A new amidrazone derivative with antimycobacterial activity

Acta Crystallographica Section C Crystal Structure Communications, 2000
Of a series of pyridine-2-carboxamidrazone derivatives with activity against mycobacteria, the N(1)-[4-(1,1-dimethylpropyl)benzylidene] derivative reported here, C(18)H(22)N(4), is one of the most active. The predicted E isomer about the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the ...
D C, Billington, P R, Lowe, D L, Rathbone, C H, Schwalbe   +3 more
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New S-benzylisothiosemicarbazones with antimycobacterial activity

Folia Microbiologica, 2011
Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial ...
E, Petrlíková, K, Waisser, L, Heinisch, J, Stolaříková   +3 more
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Synthesis of Imidazole Derivatives with Antimycobacterial Activity

Archiv der Pharmazie, 2010
Abstract4‐Substituted 1‐(p‐methoxybenzyl)imidazoles were designed and synthesized in order to mimic parts of the structure of highly potent antimycobacterial 6‐aryl‐9‐(p‐methoxybenzyl)purines. 4‐Haloimidazoles were subjected to Pd‐catalyzed cross‐coupling in order to introduce a (hetero)aryl group, or they were converted to Grignard reagents and ...
Pedro O, Miranda, Lise-Lotte, Gundersen
openaire   +2 more sources