Results 191 to 200 of about 19,828 (226)

New S-benzylisothiosemicarbazones with antimycobacterial activity

Folia Microbiologica, 2011
Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial ...
E, Petrlíková, K, Waisser, L, Heinisch, J, Stolaříková   +3 more
openaire   +2 more sources

Highly active antimycobacterial derivatives of benzoxazine

Bioorganic & Medicinal Chemistry, 2010
New 3-(4-alkylphenyl)-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-(4-alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dithiones were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii.
Eva, Petrlíková, Karel, Waisser, Hana, Divišová, Petra, Husáková, Petra, Vrabcová, Jiří, Kuneš, Karel, Kolář, Jiřina, Stolaříková   +7 more
openaire   +2 more sources

Phytochemistry and antimycobacterial activity of Chlorophytum inornatum

Phytochemistry, 2006
In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as
O’Donnell, Gemma, Bucar, Franz, Gibbons, Simon   +2 more
openaire   +3 more sources

Synthesis and antimycobacterial activity of nitroxanthones. 2nd communication: antimycobacterial activity.

Arzneimittel-Forschung, 1997
The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise interpretation by means of the bacterial growth kinetics method.
W G, Ibrom, K J, Schaper, A W, Frahm
openaire   +1 more source

Synthetic piperine amide analogs with antimycobacterial activity

Chemical Biology & Drug Design, 2017
Piperine amide analogs are synthesized by replacement of the piperidine moiety with different types of cyclic amines, including adamantyl and monoterpene‐derived fragments. The compounds are screened for activity against Mycobacterium tuberculosis H37Rv.
Irena Philipova, Violeta Valcheva, Rositsa Mihaylova, Mina Mateeva, Irini Doytchinova, Georgi Stavrakov   +5 more
openaire   +2 more sources

Synthesis of Imidazole Derivatives with Antimycobacterial Activity

Archiv der Pharmazie, 2010
Abstract4‐Substituted 1‐(p‐methoxybenzyl)imidazoles were designed and synthesized in order to mimic parts of the structure of highly potent antimycobacterial 6‐aryl‐9‐(p‐methoxybenzyl)purines. 4‐Haloimidazoles were subjected to Pd‐catalyzed cross‐coupling in order to introduce a (hetero)aryl group, or they were converted to Grignard reagents and ...
Pedro O, Miranda, Lise-Lotte, Gundersen
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A new amidrazone derivative with antimycobacterial activity

Acta Crystallographica Section C Crystal Structure Communications, 2000
Of a series of pyridine-2-carboxamidrazone derivatives with activity against mycobacteria, the N(1)-[4-(1,1-dimethylpropyl)benzylidene] derivative reported here, C(18)H(22)N(4), is one of the most active. The predicted E isomer about the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the ...
D C, Billington, P R, Lowe, D L, Rathbone, C H, Schwalbe   +3 more
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Synthesis and antimycobacterial activity of calpinactam derivatives

Bioorganic and Medicinal Chemistry Letters, 2012
Synthesis of calpinactam 1, a fungal antimycobacterial metabolite, utilizing solid-phase peptide synthesis is described. To explore the structure-activity relationships of 1, its derivatives with different amino acids were also synthesized on the basis of the same synthetic strategy.
Kenichiro, Nagai, Nobuhiro, Koyama, Noriko, Sato, Chisato, Yanagisawa, Hiroshi, Tomoda   +4 more
exaly   +3 more sources

Antimycobacterial activity of UDP-galactopyranose mutase inhibitors

International Journal of Antimicrobial Agents, 2010
The galactofuran region of the mycobacterial cell wall consists of alternating 5- and 6-linked beta-d-galactofuranose (beta-D-Galf) residues, essential for viability. UDP-galactofuranose (UDP-Galf), the donor for Galf, is synthesised from UDP-galactopyranose (UDP-Galp) by the enzyme UDP-galactopyranose mutase (UGM), which is not found in humans ...
Silvia, Borrelli, Wesley F, Zandberg, Sankar, Mohan, Mary, Ko, Fidel, Martinez-Gutierrez, Sarathy Karunan, Partha, David A R, Sanders, Yossef, Av-Gay, B Mario, Pinto   +8 more
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Mixed Steroidal 1,2,4,5-Tetraoxanes:  Antimalarial and Antimycobacterial Activity

Journal of Medicinal Chemistry, 2002
Mixed 1,2,4,5-tetraoxanes possessing simple spirocycloalkane and spirocholic acid-derived substituents were prepared and shown to have significantly higher in vitro antimalarial activity than bis-substituted tetraoxanes. Out of 41 synthesized tetraoxanes, 12 were in vitro more potent against Plasmodium falciparum chloroquine-resistant W2 clone than ...
Solaja BA, Terzic N, Pocsfalvi G, Gerena L, Tinant B, Opsenica D, Milhous WK   +6 more
openaire   +7 more sources