Results 71 to 80 of about 14,174 (200)
Antinociceptive effects of (±)-, (+)- and (-)-nefopam in mice
Journal of Pharmacy and Pharmacology, 1987 Abstract The antinociceptive activity of (±)-, (+)- and (-)-nefopam in mice has been examined using the hot-plate, formalin and tail-flick tests. Nefopam was administered by the intraperitoneal, intracerebroventricular (i.c.v.) and intrathecal (i.th.) routes. Intraperitoneal injection of (±)-nefopam (10–20 mg kg−1) had powerful analgesic
O B, Fasmer +3 more
openaire +2 more sources
Activation of KATP channels in pain modulation: a systematic review of preclinical studies
Frontiers in PhysiologyObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich +3 more
doaj +1 more source
, 2007 Microinjection of neurotensin (NT) into the rostral ventromedial medulla (RVM) produces dose-dependent antinociception. Here we show that antinociception produced by intra-RVM microinjection of neurotensin (NT) or the selective NT receptor subtype 1 ...
Gebhart, G. F. +2 more
core
Ingested bovine amniotic fluid enhances morphine antinociception in rats
, 2000 Ingestion by rats of rat placenta or amniotic fluid enhances opioid-mediated, or partly opioid-mediated, antinociception produced by morphine injection, vaginal or cervical stimulation, late pregnancy, and foot shock.
Corpening, James W. +2 more
core
Frontiers in Pharmacology, 2018 Isodon rugosus Wall. ex. Benth is an important species and is used in folk medicine for different types of pains such as abdominal pain, earache, toothache, gastric, and generalized body pain. Recently, we also have reported the antinociceptive potential
Abdul Sadiq +6 more
doaj +1 more source
Multiple Receptors Involved in Peripheral α2, μ, and A1Antinociception, Tolerance, and Withdrawal
, 1997 We examined the interactions among three classes of peripherally-acting antinociceptive agents (μ-opioid, α2-adrenergic, and A1-adenosine) in the development of tolerance and dependence to their antinociceptive effects.
K. O. Aley, Jon D. Levine
core +1 more source
Efficacy of Piperine for management of pulpal dental pain
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2002 Background and Objective: Management of painful irreversible pulpitis is one of the most common cases of dental emergencies. Since, in traditional medications, piperine was used for management of dental pain, this study was done to determine the efficacy
Z Madani, AK Moghadam Nia, Z Kashiri
doaj
, 2013 A) Proposed model of reduced analgesia produced by the MOR/DOR heteromer in mice treated with methadone/NTB cocktail, where DOR/MORs are anti-analgesic and contribute to poor antinociception.
Laura Milan-Lobo (390176) +3 more
core +1 more source
A role for endocannabinoids in indomethacin-induced spinal antinociception
, 2002 dInhibition of prostaglandins synthesis does not completely explain non-steroidal anti-inflammatory drug-induced spinal antinociception. Among other mediators, endocannabinoids are involved in pain modulation. Indomethacin-induced antinociception, in the
Kotalla, CE +6 more
core +2 more sources
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats
, 2014 Exercise-induced antinociception is widely described in the literature, but the mechanisms involved in this phenomenon are poorly understood. Systemic (s.c.) and central (i.t., i.c.v.) pretreatment with CB? and CB? cannabinoid receptor antagonists (AM251
Di Marzo V +10 more
core +1 more source