Results 61 to 70 of about 1,146,119 (350)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays

Molecules, 2021
Background: Oxidative stress is a key factor in the pathophysiology of many diseases. This study aimed to verify the antioxidant activity of selected plant phenolics in cell-based assays and determine their direct or indirect effects.
Jakub Treml, Petra Večeřová, Petra Herczogová, Karel Šmejkal   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

OXIDATIVE CHANGES OF LIPIDS, PROTEINS AND ANTIOXIDANTS IN YOGURT DURING THE SHELF LIFE [PDF]

, 2017
Background: Oxidation processes in milk and yogurt during the shelf life can result in an alteration of protein and lipid constituents. Therefore, the antioxidant properties of yogurt in standard conditions of preservation were evaluated. Results: Total
Bellamio, Marco, Bindoli, Alberto, Citta, Anna, Feller, Emiliano, Folda, Alessandra, Rigobello, MARIA PIA, Scalcon, Valeria, Scutari, Guido   +7 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Antioxidant activity of phenolic compounds

Grasas y Aceites, 1993
This review deals with the oxidation processes induced by light and atmospheric oxygen, as well as the protective action on antioxidant compounds. The available data on the synthetic antioxidants and the problems associated to their use, together with ...
R. Maestro Durán, R Borja Padilla
doaj   +1 more source

Antioxidant Assay and Total Flavonoid Determination of Ethanolic Extract of Walnut (Canarium indicum L.) Leaves and Its Fractions

Jurnal Ilmu Dasar, 2023
Antioxidants are compounds that inhibit free radicals. Many plants have antioxidant activity because they contain antioxidant compounds such as flavonoids.
Lukmanto Lukmanto, Nadila Ikhda Ramadhani Fadhila, Lestyo Wulandari, Endah Puspitasari   +3 more
doaj   +1 more source

Optimization of extraction conditions of antioxidant activity from zingiber zerumbet oleoresin [PDF]

, 2011
The health promoting capacity of natural antioxidant from phytochemicals has increase attention from researchers and public. However, processing is affecting the activity and the bioavailability of bioactive compounds.
Abdul Aziz, Ramlan, Hasham Hisam, Rosnani, Mohamed Noor, Norhayati, Roslan, Mohd. Najib, Sarmidi, Mohamad Roji   +4 more
core   +1 more source

Antioxidant Activity of Perphenazine

Acta Poloniae Pharmaceutica - Drug Research
Reactive oxygen species (ROS) play a dual role in the human body; they are essential for normal cellular signaling but, when produced in excess, can disrupt metabolic processes and induce oxidative stress. The body relies on various defense mechanisms to neutralize ROS.
Michal Otreba, Anna Rzepecka-Stojko, Łukasz Marek, Tiago Rodriguez, Jerzy Stojko   +4 more
openaire   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source