Results 121 to 130 of about 216,604 (308)

Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient

, 2019
Friedreich’s ataxia (FRDA) is a progressive neuromuscular disorder caused by substantial decrease of mitochondrial protein frataxin responsible for biogenesis of iron-sulphur clusters and protection from oxidative damage.
Yoon-Yen YOW (8142342), Lee-Wei LIM (8142345), Kah-Hui WONG (8142348), Sze-Yuen LEW (8142339)   +3 more
core   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Pharmacological Effects of Humic Substances and Their Signaling Mechanisms

Molecules
This comprehensive review presents the results of an in-depth analytical literature search on the biological activity of humic substances and their possible pharmacological mechanisms of action.
Maria V. Zykova, Evgenia S. Trofimova, Lyudmila A. Azarkina, Tatyana V. Lasukova, Dmitrii A. Mihalyov, Larisa A. Drygunova, Marina G. Danilets, Anastasia A. Ligacheva, Andrey V. Tsupko, Sergey R. Bashirov, Mikhail V. Belousov   +10 more
doaj   +1 more source

Caracterização da atividade antioxidante e inibidora da tirosinase de substâncias extraídas da Araucaria angustifolia (Bertol.) Kuntze e encapsulação em nanopartículas biodegradáveis [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaEste estudo teve como objetivo caracterizar a atividade antioxidante e inibidora da tirosinase de substâncias extraídas da ...
Seccon, Andrea
core  

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

The Antioxidant System of the Respiratory Tract The Intracellular Antioxidant Protection in the Respiratory Tract (Part 2)

, 2016
The literature review presents the current data about the enzyme of intracellular antioxidant protection in the respiratory tract — catalase. The characteristics of catalase is presented and its functioning is described. Inactivation of hydrogen peroxide
A.E. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Momordica charantia-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis. [PDF]

Molecules, 2023
Wang F, Yuan M, Shao C, Ji N, Zhang H, Li C.   +5 more
europepmc   +1 more source

The Antioxidant System in the Respiratory Tract The Intracellular Antioxidant Protection in the Respiratory Tract (Part 1)

, 2016
The literature review presents modern data on the intracellular antioxidant protection in the respiratory tract. The induction of the enzyme synthesis of antioxidant system is described.
A.Ye. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
core   +1 more source