Results 101 to 110 of about 4,162,843 (311)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A Comparative Study Between Alcoholics of Koraga Community, Alcoholics of General Population and Healthy Controls for Antioxidant Markers and Liver Function Parameters

Online Journal of Health & Allied Sciences, 2010
Objectives: It is well established that long-term alcohol consumption leads to liver cirrhosis and other related disorders. Sufficient work has been done on biochemical markers of liver damage and antioxidant status of chronic alcoholics in general ...
Virupaksha Devaramane, Manjunatha S Muttigi, Vivekananda Kedage, Lakshmi S Prabhu, Mahesh S Shetty, Prasiddha Tilak, Naureen Anwar, Mungli Prakash, Panambur V Bhandary   +8 more
doaj  

Investigation of antioxidant status in children with acute otitis media and tonsillitis

, 2004
Objective: Antioxidant enzymes status was investigated in children with acute otitis media (AOM) and acute tonsillitis. The aim was to determine the effect of oxidative damage due to free radicals on the antioxidant enzymes status in children with AOM ...
BAYIROĞLU, F, Hüseyin Çaksen, CEMEK, Mustafa, Cemek, F, Dulger, H, Dede, Semiha, Fatma Cemek, Bayıroğlu, F, Dede, S, Fahri Bayıroğlu, Dede, Süreyya, Semiha Dede, USTUN, Ramazan, Haluk Dülger, Çaksen, H, CEMEK, M, Ramazan Üstünc, Üstün, R, Mustafa Cemek   +18 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

The Effects of Two Different Aquaculture Methods on Water Quality, Microbial Communities, Production Performance, and Health Status of Penaeus monodon

Fishes
The tiger shrimp Penaeus monodon is a commercially important species; however, the intensification of the farming of this species has led to the production and release of significant amounts of organic waste.
Huan Ren, Yu Xu, Lu Jing, Haochang Su, Xiaojuan Hu, Yucheng Cao, Guoliang Wen   +6 more
doaj   +1 more source

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

The relationship between plasma lipids, oxidant–antioxidant status, and glycated proteins in individuals at risk for atherosclerosis

, 2019
Sylwia Dzięgielewska-Gęsiak,1 Alicja Płóciniczak,2 Katarzyna Wilemska-Kucharzewska,1 Teresa Kokot,1 Małgorzata Muc-Wierzgoń,1 Ewa Wysocka21Department of Internal Medicine, Medical University of Silesia, 44-902 Bytom, Poland; 2Department of ...
Płóciniczak A, Muc-Wierzgoń M, Kokot T, Dzięgielewska-Gęsiak S, Wysocka E, Wilemska-Kucharzewska K   +5 more
core  

Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy

Advanced Engineering Materials, EarlyView.
Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang, Jianxiang Zhao, Zhaoqi Chen, Hao Gong, Yinsen Yan, Junlei Tao, Yong Yang   +6 more
wiley   +1 more source

EFFECT OF SELENIUM SUPPLEMENTATION ON PIG PRODUCTION PROPERTIES, ANTIOXIDANT STATUS AND MEAT QUALITY [PDF]

Poljoprivreda, 2013
Food containing functional ingredients to achieve a positive effect on health and reducing the risk of infection is increasing production. It is also very important to improve the quality of pork with respect to change the genetic makeup of pigs that ...
Tomislav Šperanda
doaj