Results 81 to 90 of about 345,363 (312)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men

Czech Journal of Food Sciences, 2001
In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 ...
V. Šimánek, N. Škottová, J. Bartek, J. Psotová, P. Kosina, L. Balejová, J. Ulrichová   +6 more
doaj   +1 more source

Oxidant and Non-enzymatic Antioxidant Status in Measles [PDF]

Journal of Tropical Pediatrics, 2006
Measles is a highly contagious viral disease of childhood associated with serious complications and significant morbidity and mortality. In the present study, antioxidant and oxidant status was investigated in children with measles. Our aim was to evaluate the possible changes in non-enzymatic antioxidant levels and their relationship to the oxidative ...
Cemek, Mustafa, Dede, Semiha, Bayiroglu, Fahri, Caksen, Hueseyin, Cemek, Fatma, Mert, Nihat   +5 more
openaire   +4 more sources

Which circulating antioxidant vitamins are confounded by socioeconomic deprivation? The MIDSPAN family study [PDF]

, 2010
<p><b>Background:</b> Antioxidant vitamins are often described as having “independent” associations with risk of cancer, cardiovascular disease (CVD) and mortality.
Welsh, P, Talwar Dinesh, Mark Upton, Davey Smith George, Watt, G., Sattar, N, Sattar, N., Talwar, D., Dinesh Talwar, O'Reilly Denis, Welsh Paul, Sattar Naveed, Paul Welsh, Davey Smith, G, O'Reilly, D, Graham Watt, Upton Mark, Upton, M, Alex McConnachie, McConnachie Alex, Welsh, P., McConnachie, A., Denis O'Reilly, Talwar, D, McConnachie, A, O'Reilly, D., Watt Graham, Naveed Sattar, Watt, G, Upton, M., George Davey Smith, Davey Smith, G.   +31 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A Chinese Herbal Formulation, Xiao-Er-An-Shen Decoction, Attenuates Tourette Syndrome, Possibly by Reversing Abnormal Changes in Neurotransmitter Levels and Enhancing Antioxidant Status in Mouse Brain

Frontiers in Pharmacology, 2019
Xiao-Er-An-Shen Decoction (XEASD) has been used clinically for the treatment of Tourette syndrome (TS) in children for more than 20 years in mainland China.
Jihang Chen, Pou Kuan Leong, Hoi Yan Leung, Wing Man Chan, Zhonggui Li, Jingyu Qiu, Kam Ming Ko, Jianping Chen   +7 more
doaj   +1 more source

Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction

, 2006
The aim of this study was to determine the effects of dietary antioxidant supplementation with a-tocopherol and a-lipoic acid on cyclosporine induced alterations to erythrocyte and plasma redox balance, and cyclosporine-induced endothelial and smooth ...
Lexis, Louise., Lexis, L. A., Coombes, J. S., Andrew Fenning (9795698), Fassett, Robert., J.S. Coombes, Fenning, A., Fenning, Andrew., Coombes, Jeff., L Brown (9865289), L. Brown, Fassett, R. G., L.A. Lexis, L Lexis (9890348), A. Fenning, Brown, L., Brown, Lindsay., R.G. Fassett, R Fassett (9890351), J Coombes (9859394)   +19 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats [PDF]

Introduction: Pathogenic role of free radicals are well known in various metabolic diseases. They originate from internal and external sources of body.
رضایی مقدم, عادل, مهاجری, داریوش, شهیدی, مریم السادات, رفیعی, بهنام, مأذنی, محمد, اظهری, اصغر, دیزجی, رعنا, یگانه زاد, مهدی   +7 more
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source