Results 91 to 100 of about 842,941 (248)

Does antioxidant supplementation prevent favorable adaptations to exercise training? - Response

, 2007
[Extract] Thank you for the opportunity to respond to the points raised by Drs. Padilla and Mickleborough that relate to the discussion question, Does antioxidant supplementation prevent favorable adaptations to exercise ...
Jenkins, D., Coombes, Jeff, Knez, W., Coombes, J., Jenkins, David, Knez, Wade   +5 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Dietary Supplements and Oxidative Stress Management in Young Adults Following Intensive Exercise: A Systematic Review

Sports
Strenuous exercise is a well-established physiological stimulus that enhances muscular strength and hypertrophy but can also increase reactive oxygen species production, leading to oxidative stress (OS). Numerous studies have investigated whether dietary
Vlassios Kakouris, Maria Piagkou, George Triantafyllou, Karolina Akinosoglou   +3 more
doaj   +1 more source

Effects Of Antioxidant Supplementation And Exercise Training On Erythrocyte Antioxidant Enzymes

, 2005
Erythrocytes transport oxygen to tissues and exercise-induced oxidative stress increases erythrocyte damage and turnover. Increased use of antioxidant supplements by athletes may alter protective erythrocyte antioxidant mechanisms during training ...
Coombes, Jeff, Marsh, Sue, Laursen, Paul
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Antioxidants in male infertility: from empirical supplementation to phenotype directed therapy

Frontiers in Endocrinology
Oxidative stress is a biologically plausible contributor to male infertility, and antioxidant supplementation has been investigated for decades. Yet clinical evidence has not converged on a reproducible benefit in reproductive outcomes.
Mohammad Ishraq Zafar, Mengyuan Qu, Mengyuan Qu   +2 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Equine High-Intensity Exercise, Articular Biochemistry, and Nutritional Antioxidant Supplementation [PDF]

, 2017
The objective of this thesis was to document the response in horses to high-intensity exercise and antioxidant supplementation. In a pilot study, horses underwent an exercise test. Plasma and synovial fluid (SF) samples were taken 24 hr prior to exercise
MacNicol, Jennifer
core   +1 more source

Effect of Bamboo Leaf Extract on Antioxidant Status and Cholesterol Metabolism in Broiler Chickens

Animals, 2019
The objective of this study was to investigate the effects of dietary bamboo leaf extract (BLE) on antioxidant status and cholesterol metabolism in broilers. One-day-old male Arbor Acres (576) broilers were randomly divided into six groups.
Mingming Shen, Zechen Xie, Minghui Jia, Anqi Li, Hongli Han, Tian Wang, Lili Zhang   +6 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source