Results 81 to 90 of about 842,941 (248)

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Impact of Oxidative Stress and Antioxidants on Semen Quality in Dogs

Animals
This review focuses on the biochemical mechanisms of oxidative damage to sperm, the role of antioxidants, as well as the clinical consequences of supplementation for the improvement of sperm fertility.
Sławomir Zduńczyk, Anna Domosławska, Monika Jamioł, Marta Kankofer   +3 more
doaj   +1 more source

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Czech Journal of Animal Science, 2014
Lycopene is a carotenoid present in vegetables and ripe fruit and has been proved to be the most potent antioxidant among various common carotenoids.
B. Sun, J. Ma, J. Zhang, L. Su, Q. Xie, Y. Bi   +5 more
doaj   +1 more source

Effects of antioxidant vitamin supplementation on the risk of major cardiovascular events.

, 2013
Effects of antioxidant vitamin supplementation on the risk of major cardiovascular events.
Zhongxiang Yuan (379771), Jing Li (10611), Yizhou Ye (379770)   +2 more
core   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Dose-Dependent Effects of Selenium Methionine Supplementation on Functional, Structural, and Physiological Characteristics of Rooster Semen During Liquid Storage at 25 °C

Veterinary Sciences
The preservation of rooster semen quality during short-term liquid storage remains a challenge in poultry reproductive biotechnology because sperm cells rapidly lose functional competence under ambient conditions. This deterioration is largely associated
Areej Arif, Nousheen Zahoor, Aqsa Sadiq, Tariq Sohail, Meihui Tang, Liyue Dong, Jianqiang Tang, Sardar Zarq Khan, Guojun Dai   +8 more
doaj   +1 more source

Ação da intervenção antioxidante na síndrome de Down [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A Síndrome de Down (SD) é a mais frequente desordem genética humana, e é causada, na sua quase totalidade ...
Parisotto, Eduardo Benedetti
core  

Effects of antioxidant vitamin supplementation on the risk of cardiac death.

, 2013
Effects of antioxidant vitamin supplementation on the risk of cardiac death.
Zhongxiang Yuan (379771), Jing Li (10611), Yizhou Ye (379770)   +2 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Effects of Supervised Physiotherapy-Based Exercise on Ovarian Reserve and Spontaneous Pregnancy in Women with Diminished Ovarian Reserve: A Controlled Pilot Study

Life
Diminished ovarian reserve (DOR) is a major cause of female infertility with limited treatment options, and lifestyle interventions such as supervised, structured exercise therapy may support ovarian function. In this pilot study, we evaluated the effect
Barbara Petra Kovács, Júlia Balog, Judit F. Szigeti, Barbara Sebők, Marianna Török, Szabolcs Várbíró   +5 more
doaj   +1 more source