Results 91 to 100 of about 948,009 (300)

Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

Advanced Science, EarlyView.
A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou, Miaomiao Tian, Jingwei Yu, Jiaxin Kang, Miaomiao Chen, Yue Yuan, Lizhi Liu, Hongbo Wei   +7 more
wiley   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Hepatoprotective Efficacy of Pyrimidine Derivatives in Acute Dichloroethane Intoxication

Общая реаниматология, 2006
The paper presents the results of a study of the antioxidative and hematoprotective properties of pyrimidine derivatives: 1,3,6-trimethyl-5-hydroxyuracil and 3,6-dimethyl-5-hydrpxyuracil versus the synthetic antioxidant tonarol, а-tocopherol acetate, and
D. V. Srubilin, V. A. Myshkin, M. A. Isakova, D. A. Yenikeyev, A. I. Savlukov   +4 more
doaj   +1 more source

Colonic Dysregulation of Major Metabolic Pathways in Experimental Ulcerative Colitis

Metabolites
Inflammatory bowel disease (IBD) is multifactorial chronic inflammatory disease in the gastrointestinal tract, affecting patients’ quality of life profoundly. The incidence of IBD has been on the rise globally for the last two decades.
Ji Yeon Noh, Naser Farhataziz, Michael T. Kinter, Xin Yan, Yuxiang Sun   +4 more
doaj   +1 more source

Peroxisome Metabolism in Cancer

, 2020
Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redoxbalance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis, bile acidsynthesis, and reactive oxygen species homeostasis.
Jung Ae Kim, Jung-Ae Kim
core   +1 more source

Mathematical modelling of metabolism and acidity in cancer [PDF]

, 2014
Human cancers exhibit the common phenotype of elevated glycolytic metabolism, which causes acidification of the tissue microenvironment and may facilitate tumour invasion.
McGillen, Jessica Buono
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Plasma protein metabolism: regulation of synthesis, distribution, and degradation

, 1970
xxiv+560hlm ...
PLASMA PROTEIN METABOLISM, WALDMANN, THOMAS, ROTHSCHILD, MARCUS A.   +2 more
core  

Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases

, 2022
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and therefore is its burden of disease as NALFD is a risk factor for cirrhosis and is associated with other metabolic conditions such as type II diabetes, obesity, dyslipidaemia ...
Max Nieuwdorp, Nieuwdorp, Max, Teunis, Charlotte, Hanssen, Nordin, Charlotte Teunis, Nordin Hanssen   +5 more
core   +1 more source

Editorial: Dietary Antioxidants and Metabolic Diseases [PDF]

Frontiers in Nutrition, 2021
Daniele Vergara, Egeria Scoditti, Azlina Abdul Aziz, Anna M. Giudetti   +3 more
openaire   +3 more sources