Results 51 to 60 of about 948,009 (300)

Trefoil Factor 3 Deficiency Affects Liver Lipid Metabolism

Cellular Physiology and Biochemistry, 2018
Background/Aims: Tff3 protein plays a well recognized role in the protection of gastrointestinal mucosa. The role of Tff3 in the metabolism is a new aspect of its function.
Maro Bujak, Ivana Tartaro Bujak, Sandra Sobočanec, Martina Mihalj, Sanja Novak, Anita Ćosić, Maja Tolušić Levak, Vjekoslav Kopačin, Branka Mihaljević, Tihomir Balog, Ines Drenjančević, Mirela Baus Loncar   +11 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Metabolic Signatures of Tumor Responses to Doxorubicin Elucidated by Metabolic Profiling in Ovo

Metabolites, 2020
Background: Dysregulated cancer metabolism is associated with acquired resistance to chemotherapeutic treatment and contributes to the activation of cancer survival mechanisms.
Iman W. Achkar, Sara Kader, Shaima S. Dib, Kulsoom Junejo, Salha Bujassoum Al-Bader, Shahina Hayat, Aditya M. Bhagwat, Xavier Rousset, Yan Wang, Jean Viallet, Karsten Suhre, Anna Halama   +11 more
doaj   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles

Biosurface and Biotribology, 2023
Selenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications.
Rong Hu, Xiao Wang, Lu Han, Xiong Lu
doaj   +1 more source

Selenium biofortification enhances ROS scavenge system increasing yield of coffee plants

Ecotoxicology and Environmental Safety, 2021
There are conclusive evidences of selenium (Se) deficiency in Brazilian soils and foods. Brazil is the largest producer and consumer of coffee worldwide, which favors agronomic biofortification of its coffee.
Matheus Pereira de Brito Mateus, Renan Francisco Rimoldi Tavanti, Tauan Rimoldi Tavanti, Elcio Ferreira Santos, Arshad Jalal, André Rodrigues dos Reis   +5 more
doaj   +1 more source

Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence.

, 2009
Knowledge of the in vivo physiology and metabolism of Streptococcus pneumoniae is limited, even though pneumococci rely on efficient acquisition and metabolism of the host nutrients for growth and survival.
Andrew, Peter W., Homer, Karen A, Spissu, Francesca, Homer, Karen A., Benisty, Rachel, Porat, Nurith, Neves, Ana R., Andrew, Peter W, Yesilkaya, Hasan, Neves, Ana R, Terra, Vanessa S., Carvalho, Sandra M, Terra, Vanessa S, Carvalho, Sandra M.   +13 more
core   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis

Antioxidants, 2021
The antioxidant capacity of erythrocytes protects individuals against the harmful effects of oxidative stress. Despite improved hemodynamic efficiency, the effect of eccentric cycling training (ECT) on erythrocyte antioxidative capacity remains unclear ...
Yu-Chieh Huang, Mei-Ling Cheng, Hsiang-Yu Tang, Chi-Yao Huang, Kuan-Ming Chen, Jong-Shyan Wang   +5 more
doaj   +1 more source

Microbial metabolism of host-derived antioxidants

Current Opinion in Chemical Biology
Humans are exposed to a wide variety of small molecules with antioxidant properties that are poorly metabolized by mammalian cells. However, gastrointestinal microbes encode enzymes that convert these redox-active molecules into nutrient sources and electron acceptors to support bacterial growth in the gut. Here, we describe recent studies highlighting
Zhe Zhou, Stavroula K. Hatzios
openaire   +2 more sources