Results 61 to 70 of about 948,009 (300)

Oxidative-Antioxidant Imbalance and Impaired Glucose Metabolism in Schizophrenia [PDF]

Biomolecules, 2020
Schizophrenia is a neurodevelopmental disorder featuring chronic, complex neuropsychiatric features. The etiology and pathogenesis of schizophrenia are not fully understood. Oxidative-antioxidant imbalance is a potential determinant of schizophrenia. Oxidative, nitrosative, or sulfuric damage to enzymes of glycolysis and tricarboxylic acid cycle, as ...
Amira Bryll, Justyna Skrzypek, Wirginia Krzyściak, Maja Szelągowska, Natalia Śmierciak, Tamas Kozicz, Tadeusz Popiela   +6 more
openaire   +5 more sources

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Sulfuric Odor Precursor S-Allyl-l-Cysteine Sulfoxide in Garlic Induces Detoxifying Enzymes and Prevents Hepatic Injury

Antioxidants, 2019
S-Allyl-l-cysteine sulfoxide (ACSO) is a precursor of garlic-odor compounds like diallyl disulfide (DADS) and diallyl trisulfide (DATS) known as bioactive components.
Yusuke Yamaguchi, Ryosuke Honma, Tomoaki Yazaki, Takeshi Shibuya, Tomoya Sakaguchi, Harumi Uto-Kondo, Hitomi Kumagai   +6 more
doaj   +1 more source

Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats

Frontiers in Endocrinology, 2023
IntroductionYu–Ye Tang (YYT) is a classical formula widely used in treatment of type 2 diabetes mellitus (T2DM). However, the specific mechanism of YYT in treating T2DM is not clear.MethodsThe aim of this study was to investigate the therapeutic effect ...
Ziang Ma, Wenjuan Sun, Lixin Wang, Yuansong Wang, Baochao Pan, Xiuhai Su, Hanzhou Li, Hui Zhang, Shuquan Lv, Hongwu Wang   +9 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Azelaic Acid-Mediated Resistance in Rice Against Infection by Bipolaris oryzae

Plants
Brown spot, caused by the fungus Bipolaris oryzae, has led to significant yield losses in rice production worldwide. This study hypothesized that azelaic acid (AzA) could reduce brown spot symptoms in rice leaves by potentiating biochemical defense ...
Geovane Souza Gudin, Leandro Castro Silva, Bárbara Bezerra Menezes Picanço, Aline Vieira Barros, Verônica Vieira Brás, Fabrício Ávila Rodrigues   +5 more
doaj   +1 more source

Cold hardiness in Ostrinia nubilalis (Lepidoptera: Pyralidae): Glycerol content, hexose monophosphate shunt activity, and antioxidative defense system

European Journal of Entomology, 2004
Many insects in temperate regions overwinter in diapause, during which they are cold hardy. In these insects, one of the metabolic adaptations to the unfavorable environmental conditions is the synthesis of cryoprotectants/anhydroprotectants.
Bojana STANIC, Aleksandra JOVANOVIC-GALOVIC, Dusko P. BLAGOJEVIC, Gordana GRUBOR-LAJSIC, Roger WORLAND, Mihajlo B. SPASIC   +5 more
doaj   +1 more source

Enzymatic Antioxidant Defense and Polymorphic Changes in Male Infertility

Antioxidants, 2022
The intensification of oxidative stress and destabilization of the antioxidative defenses of an organism is a consequence of many environmental factors.
Jędrzej Baszyński, Piotr Kamiński, Maria Bogdzińska, Sławomir Mroczkowski, Marek Szymański, Karolina Wasilow, Emilia Stanek, Karolina Hołderna-Bona, Sylwia Brodzka, Rafał Bilski, Halyna Tkachenko, Natalia Kurhaluk, Tomasz Stuczyński, Małgorzata Lorek, Alina Woźniak   +14 more
doaj   +1 more source