Results 61 to 70 of about 3,292,255 (346)

Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]

, 2019
The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
core   +1 more source

Structures, targets and recent approaches in anti-leishmanial drug discovery and development. [PDF]

, 2011
Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002.
Seifert, Karin
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10 [PDF]

Open Biology, 2019
Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor clinical outcomes. Here we used
Carolyn N. Paulson, Kristen John, Ryan M. Baxley, Fredy Kurniawan, Kayo Orellana, Rawle Francis, Alexandra Sobeck, Brandt F. Eichman, Walter J. Chazin, Hideki Aihara, Gunda I. Georg, Jon E. Hawkinson, Anja-Katrin Bielinsky   +12 more
doaj   +1 more source

Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]

, 2012
Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu, Oga, Enoche, Shitara, Yoshihisa, Shuichi, Sekine   +3 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information

Case Reports in Oncology, 2021
Fenbendazole is a benzimidazole anthelmintic agent, with a broad antiparasitic range in animals such as dogs and pigs. The agent is also reported to exert antitumor effects and inhibit microtubule-associated tubulin polymerization, but its safety and ...
Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida   +4 more
doaj   +1 more source

Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni

Pharmaceuticals, 2021
The intravascular parasitic worm Schistosoma mansoni is a causative agent of schistosomiasis, a disease of great global public health significance. Praziquantel is the only drug available to treat schistosomiasis and there is an urgent demand for new ...
R. Porto, Ana C Mengarda, Rayssa A. Cajás, M. Salvadori, Fernanda S. Teixeira, D. Arcanjo, A. Siyadatpanah, M. L. Pereira, P. Wilairatana, J. Moraes   +9 more
semanticscholar   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Real Time Anti-<em>Toxoplasma gondii </em>Activity of an Active Fraction of <em>Eurycoma longifolia</em> Root Studied by <em>in Situ</em> Scanning and Transmission Electron Microscopy

Molecules, 2012
The inhibitory effect of active fractions of <em>Eurycoma<strong> </strong>longifolia </em>(<em>E. longifolia</em>)<em> </em>root, namely TAF355 and TAF401, were evaluated against <em>Toxoplasma ...
Sreenivasan Sasidharan, Chan Kit-Lam, Rahmah Noordin, Nowroji Kavitha   +3 more
doaj   +1 more source