Results 61 to 70 of about 22,500 (289)

Microbial metabolites in nutrition, healthcare and agriculture [PDF]

, 2017
Microorganisms are a promising source of an enormous number of natural products, which have made significant contribution to almost each sphere of human, plant and veterinary life. Natural compounds obtained from microorganisms have proved their value in
Anshumali Mittal, Manoj Kumar, Praveen Kumar Mehta, Rajendra Singh   +3 more
core   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Transcriptomic Analysis of Tambaqui (Colossoma macropomum) Exposed to Trichlorfon-Induced Toxicity

Animals
Trichlorfon is an antiparasitic agent widely used to control pests and parasites in farmed fish. Tambaqui (C. macropomum) is the most commercially important characid species farmed in the Amazon region.
Hallana Cristina Menezes da Silva, Igor Kelvyn Cavalcante Lobo, André Gentil da Silva, Ana Lúcia Silva Gomes, Wallice Paxiúba Duncan, Juliana Costa Silva, Fabrício M. Lopes, Roberto Ferreira Artoni, Daniele Aparecida Matoso   +8 more
doaj   +1 more source

Identification of 3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors against Trypanothione Reductase from Leishmania Infantum Using Molecular Docking and ADMET Prediction

Molecules, 2021
Polyphenolic and Terpenoids are potent natural antiparasitic compounds. This study aimed to identify new drug against Leishmania parasites, leishmaniasis’s causal agent. A new in silico analysis was accomplished using molecular docking, with the Autodock
Sarra Maamri, Khedidja Benarous, Mohamed Yousfi   +2 more
doaj   +1 more source

Structures, targets and recent approaches in anti-leishmanial drug discovery and development. [PDF]

, 2011
Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002.
Seifert, Karin
core   +2 more sources

Enhanced deoxyviolacein bioproduction via enzyme condensation with a yeast glycolytic enzyme‐derived peptide tag

Biotechnology Progress, EarlyView.
Fusion of a 27‐amino‐acid peptide tag derived from a glycolytic enzyme enabled artificial assembly formation of the two violacein biosynthetic enzymes, VioE and VioC. This assembly resulted in enhanced biosynthesis of deoxyviolacein. Abstract In microbial production, regulating endogenous and exogenous synthetic pathways is essential.
Rioko Ito, Sayoko Ito‐Harashima, Naoko Segawa, Natsuko Miura, Michihiko Kataoka   +4 more
wiley   +1 more source

Could the Biological Potency of Porcelia macrocarpa R.E. Fries (Annonaceae) be Linked to Its Diverse Metabolite Profile?

Chemistry &Biodiversity, EarlyView.
ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard, Ivanildo A. Brito, Emerson A. Oliveira, Mariana H. Chaves, João Henrique G. Lago   +4 more
wiley   +1 more source

ANTHELMINTIC DRUGS EFFICACY AGAINST BOVINE FASCIOLIASIS

Ветеринарная патология, 2022
Parasitic diseases in cattle are widespread in the territory of the Russian Federation. At the farms of Udmurtia various kinds of ruminants parasitic fauna are represented and therefore the vast use of antiparasitic drugs entails a range of problems ...
E. S. Klimova
doaj   +1 more source

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, EarlyView.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source