Fall-related injuries in a nursing home setting: is polypharmacy a risk factor?
BMC Health Services Research, 2009 Background Polypharmacy is regarded as an important risk factor for fallingand several studies and meta-analyses have shown an increased fall risk in users of diuretics, type 1a antiarrhythmics, digoxin and psychotropic agents.
Colli Cristiano +8 more
doaj +1 more source
Prescription rate of medications potentially contributing to lower urinary tract symptoms and detection of adverse reactions by prescription sequence symmetry analysis [PDF]
, 2015 BACKGROUND: The lower urinary tract symptoms (LUTS) increases with age and can have a significant effect on the quality of life of the patients. Elderly patients, who are often characterized by a decline in physiological functional and polypharmacy, are ...
Fumihiko Ando +5 more
core +2 more sources
Pharmacy Practice, 2018 Objective: The objective of this study is to compute the potential benefit of Pramipexole ER on total levodopa equivalent dose (LED) and Unified Parkinson Disease Rating Score (UPDRS-III) compared to mono- or combined therapy of pramipexole IR and/or ...
Faddoul L +5 more
doaj +1 more source
Frontiers in Neurology, 2019 Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons, appearance of Lewy bodies and presence of neuroinflammation.
Elisa Storelli +4 more
doaj +1 more source
Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention [PDF]
, 2010 Background Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition ...
Amarie, Oana Veronica +8 more
core +1 more source
Health-related quality of life and depression among participants in the Sjögren's International Collaborative Clinical Alliance registry. [PDF]
, 2017 ObjectiveTo examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS.MethodsCross-sectional study of participants in the Sjögren's ...
Chou, Annie +5 more
core +1 more source
N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor [PDF]
, 2014 On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which ...
Agbaba, D. +13 more
core +3 more sources
Evidence-based guidelines for the antipsychotic drugs: Schizophrenia
Psychiatry and Clinical Psychopharmacology, 2021 Antipsychotic medications, as the standard pharmacologic treatment of schizophrenia, are used to decrease symptoms and to increase functioning. The currently available antipsychotics are all significantly efficacious for positive symptoms.
Özcan Uzun
doaj
, 2023 Psychiatry and Clinical Neurosciences, Volume 77, Issue 6, Page 365-366, June 2023.
Taro Kishi +5 more
wiley +1 more source
ChemistrySelect, Volume 11, Issue 2, 15 January 2026.Three phenanthrene alkaloids from Guatteria olivacea were studied by DFT, docking, MD, and cytotoxicity assays. All compounds showed stable binding to DNA–topoisomerase II and human serum albumin. Atherosperminine exhibited cytotoxic activity against four cancer cell lines, supporting its potential as a topoisomerase II inhibitor and anticancer ...
Renyer A. Costa +8 more
wiley +1 more source