Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács +9 more
wiley +1 more source
Benzoxaboroles Are Inhibitors of the η‐Class Carbonic Anhydrase From Plasmodium falciparum
Benzoxaborole‐based inhibitors demonstrate potent, low‐micromolar inhibition of the essential malaria target PfaCA and are effective in vitro suppression of P. falciparum. Molecular docking confirms target engagement via zinc coordination, establishing this chemotype as a promising scaffold for the development of next‐generation antimalarials ...
Alessandro Bonardi +9 more
wiley +1 more source
ALTERNATIVE METHODS FOR ASSESSING USEFUL PROPERTIES OF NON-WOOD FOREST PRODUCTS
The article presents a study of pre-developed phyto-compositions for the preparation of hot drinks based on birch chaga (Inonotus obliquus) with the addition of various plant materials (herbs, berries, lichen).
Anna S. Olkova, Evgeniya V. Tovstik
doaj +1 more source
The in vitro and in vivo testing of chemotherapeutic agents against pathogenic free living amebae : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University, Palmerston North, New Zealand. [PDF]
During the last ten years, there has been an increasing awareness of sporadic cases of Primary Amoebic Meningo-encephalitis (PAM) affecting primarily younger age groups and appearing in an acute fulminant form. The earliest positive case (Willaert, 1974)
Elmsly, Christopher John
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New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum [PDF]
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity.
Elena Talero +6 more
core +1 more source
Spiranthes spiralis L. seed methanol extract was morphologically and chemically characterized using microscopy, FT‐IR, GC–MS, and in silico analyses. The extract exhibited high phenolic content and strong DPPH radical scavenging activity, while GC–MS identified 22 bioactive compounds with notable binding affinity toward the GPR52 receptor.
Erdi Can Aytar +7 more
wiley +1 more source
Promising selective MAO-B inhibition by sesamin, a lignan from Zanthoxylum flavum stems
Monoamine oxidase inhibition is an important therapeutic approach for various neurodegenerative disorders. Reversible MAO inhibitors selectively targeting only one isoform possess substantial merit in terms of safety, efficacy, and side effect profile ...
Shaymaa M. Mohamed +5 more
doaj +1 more source
Overview of Genus Prosopis Toxicity Reports and its Beneficial Biomedical Properties [PDF]
Secondary plant metabolites are regarded as promising sources of plant-protecting substances and they are one of the most important lines of plant defense against pests. The range of cellular targets for these substances is very wide and covers metabolic
Gamarra Luques, Carlos Diego +3 more
core +1 more source
We investigated how temperature and relative humidity influence the parasitic fungus Hesperomyces harmoniae on the invasive ladybird Harmonia axyridis under controlled laboratory conditions. Abiotic factors significantly affect parasitism: High relative humidity increased parasite prevalence, development rate, and load, while both low and high ...
Michiel D. de Groot +8 more
wiley +1 more source
Microbial Population and Fermentation Characteristic in Response to Sapindus Rarak Mineral Block Supplementation [PDF]
This experiment was conducted to evaluate the effect of supplementation with lerak extract combined with mineral block on protozoal and bacterial population, and fermentation characteristic in vitro.
Astuti, D. A. (D) +3 more
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