Results 61 to 70 of about 8,234 (175)

Synthesis of Oxazolyl‐Piperidines Bearing a Quaternary Stereocenter Through a Multicomponent Reaction Involving α‐Isocyanoacetates and Piperidones

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Straightforward access to oxazole‐containing piperidines through a multicomponent reaction from α‐isocyanoacetates is described. By expanding the reactivity of these a‐isocyanoacetates from aldehydes to ketones, this process efficiently delivers oxazolyl‐piperidines bearing a quaternary stereocenter as valuable scaffolds relevant to drug discovery. The
Roshan Chandrakant Kajare, Gilles Argouarch, Nicolas Gouault, Claudia Lalli   +3 more
wiley   +1 more source

ALTERNATIVE METHODS FOR ASSESSING USEFUL PROPERTIES OF NON-WOOD FOREST PRODUCTS

Siberian Journal of Life Sciences and Agriculture
The article presents a study of pre-developed phyto-compositions for the preparation of hot drinks based on birch chaga (Inonotus obliquus) with the addition of various plant materials (herbs, berries, lichen).
Anna S. Olkova, Evgeniya V. Tovstik
doaj   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, Volume 38, Issue 34, 17 June 2026.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Nutritional Composition, Therapeutic Benefits, and Functional Food Potential of Coleus amboinicus: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Coleus amboinicus is a nutrient‐rich herb containing vitamins (A‐, C‐, B‐complex), minerals (Ca, Mg, Fe, K), dietary fiber, and potent bioactives such as rosmarinic acid, quercetin, thymol, and carvacrol. These compounds contribute to antioxidant, anti‐inflammatory, antimicrobial, prebiotic, and cardioprotective benefits.
Shani Upadhyay, Rakesh Verma, Shikha Gupta   +2 more
wiley   +1 more source

Graph‐Theoretical Approach for Predicting Physicochemical Properties of Stiff‐Person Syndrome Drugs

ChemistryOpen, Volume 15, Issue 6, June 2026.
Graph‐theoretical descriptors derived from M‐polynomials are integrated with quantitative structure–property relationship modeling and machine learning to uncover structure–property relationships of drugs used in stiff‐person syndrome. Strong correlations between degree‐based topological indices and key physicochemical properties are revealed ...
Jabbar Ali, Yasir Ali, Maher Ali Malik, Yilun Shang   +3 more
wiley   +1 more source

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure.

PLoS ONE, 2017
The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to sapogenins by rumen microorganisms they become inactive. We hypothesised that the combination of saponins with glycosidase-inhibiting iminosugars might potentially
Eva Ramos-Morales, Gabriel de la Fuente, Robert J Nash, Radek Braganca, Stephane Duval, Marc E Bouillon, Martina Lahmann, C Jamie Newbold   +7 more
doaj   +1 more source

Anti-protozoal Activity of Conifer Green Needle Complex against

Natural Product Communications, 2019
Treatment of Trichomonas vaginalis typically involves using nitroimidazoles (such as metronidazole and tinidazole). Some T. vaginalis strains have become resistant to these drugs, so the development of new drugs is necessary.
Lidia B. Kulyashova, Natalia Roschina, Tamara V. Nikitina, Vagif S. Soultanov   +3 more
doaj   +1 more source

Synthesis and antiprotozoal activity of some imidazoles derivatives

Journal of Pharmacy and Pharmacology, 1964
Abstract The synthesis and in vitro antiprotozoal activity of a series of nitroimidazoles are described. A substituted phenyl group and, in many of the compounds, a N-substituent were also present: vinylogues of some of the compounds are described.
G P, ELLIS, C, EPSTEIN, C, FITZMAURICE, L, GOLBERG, G H, LORD   +4 more
openaire   +2 more sources

Antiprotozoal Activity of Tricyclic Compounds [PDF]

Science, 1985
E L, Hewlett, R D, Pearson, D, Zilberstein, D M, Dwyer   +3 more
openaire   +2 more sources