Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense. [PDF]
, 2016 A new series of N-substituted S-(2,4-dinitrophenyl)glutathione dibutyl diesters were synthesized to improve in vitro anti-protozoal activity against the pathogenic parasites Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania donovani.
Croft, Simon L +3 more
core +2 more sources
Repositioning Imipramine for Antiparasitic Effects Against Giardia lamblia
Drugs and Drug CandidatesBackground/Objectives: Giardia lamblia is an intestinal protozoan responsible for giardiasis, a globally prevalent parasitic disease. Current therapeutic options, including nitroimidazoles and benzimidazoles, have increasing treatment failures due to ...
Xareni Zinereth Herrera-Valero +6 more
doaj +1 more source
Overview of Genus Prosopis Toxicity Reports and its Beneficial Biomedical Properties [PDF]
, 2016 Secondary plant metabolites are regarded as promising sources of plant-protecting substances and they are one of the most important lines of plant defense against pests. The range of cellular targets for these substances is very wide and covers metabolic
Gamarra Luques, Carlos Diego +3 more
core +1 more source
Bisguanidine, Bis(2-aminoimidazoline), and Polyamine Derivatives as Potent and Selective Chemotherapeutic Agents against Trypanosoma brucei rhodesiense. Synthesis and in Vitro Evaluation [PDF]
, 2013 The in vitro screening for trypanocidal activity against Trypanosoma brucei rhodesiense of an in-house library of 62 compounds [i.e. alkane, diphenyl, and azaalkane bisguanidines and bis-(2-aminoimidazolines)], which were chosen for their structural ...
Brun, Reto, Dardonville, Christophe
core +2 more sources
Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids [PDF]
, 2017 We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids.
Elisa García +8 more
core +2 more sources
Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids [PDF]
, 2017 The synthesis and biological activities (cytotoxicity, leishmanicidal, and trypanocidal) of 11 triclosan–hydrazone hybrids are described herein. The structure of the products was elucidated by spectral data (NMR, IR) and mass spectrometric analyses.
Iván D. Vélez +6 more
core +3 more sources
Structural modifications of quinoline-based antimalarial agents: Recent developments
Journal of Pharmacy and Bioallied Sciences, 2010 Antimalarial drugs constitute a major part of antiprotozoal drugs and have been in practice for a long time. Antimalarial agents generally belong to the class of quinoline which acts by interfering with heme metabolism. The recent increase in development
Sandhya Bawa +3 more
doaj +1 more source
48: DRUG SCREENING OF NOVEL ANTIPROTOZOAL AGENTS AGAINST GIARDIA DUODENALIS
Journal of Global Antimicrobial Resistance, 2022 B. Knight +3 more
doaj +1 more source