Results 71 to 80 of about 8,093 (191)

Antileishmanial potential of medicinal plants: A global systematic and meta-analytic review of in vitro studies [PDF]

Journal of HerbMed Pharmacology
Introduction: Leishmaniasis is a major global health challenge with limited treatment options and rising drug resistance. Medicinal plants, traditionally used in many regions, offer a promising source of new antileishmanial agents.
Mohammed-Yassine Takzima, Mohamed Echchakery, Mounia Amane, Mohamed Hafidi, Loubna El fels   +4 more
doaj   +1 more source

Development, Synthesis and Antiprotozoal Assessment of New Substituted Diquinolinyl-Pyridine Derivatives as Antiparasitic Agents by Potential G-4 Binding

, 2023
Rabindra Nath Das, Anita Cohen, Clotilde Boudot, Solène Savrimoutou, Sandra Albenque-Rubio, Stéphane Moreau, Jean‐Louis Mergny, Luisa Ronga, Ioannis Kanavos, Charles Descamps, Valentin Verdier, Patrice Agnamey, Catherine Mullié, Bertrand Courtioux, Pascal Sonne, Jean Guillon   +15 more
openalex   +1 more source

Novel Ferrocenyl-substituted Organometallics with Pyrimidine Moiety as Potent Antiprotozoal Agents: Synthesis, Characterization and in Silico Evaluation

, 2023
Humaira Parveen, Mohmmad Younus Wani, Fatimah A. Alotaibi, Sayeed Mukhtar, Uzma Faridi   +4 more
openalex   +1 more source

Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Molecules
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra   +7 more
doaj   +1 more source

Design, Synthesis, In Vitro and In Silico Biological Evaluation of New Pyridine-2,5-Dicarboxylates Esters Bearing Natural Source Fragments as Anti-Trypanosomatid Agents

Pharmaceutics
Background: Chagas disease and leishmaniasis remain public health concerns. Despite the existence of approved medications for the treatment of these diseases, most patients discontinue treatment due to long drug regimens and/or the severe side effects of
Luis M. Sánchez-Palestino, Adriana Moreno-Rodríguez, Diana V. Navarrete-Carriola, Marlet Martínez-Archundia, Marhian López-Vargas, Liliana Argueta-Figueroa, Lenci K. Vázquez-Jiménez, Alma D. Paz-González, Eyra Ortiz-Pérez, Michael P. Doyle, Gildardo Rivera   +10 more
doaj   +1 more source

Repositioning Imipramine for Antiparasitic Effects Against Giardia lamblia

Drugs and Drug Candidates
Background/Objectives: Giardia lamblia is an intestinal protozoan responsible for giardiasis, a globally prevalent parasitic disease. Current therapeutic options, including nitroimidazoles and benzimidazoles, have increasing treatment failures due to ...
Xareni Zinereth Herrera-Valero, Sendar Daniel Nery-Flores, Filiberto Gutiérrez-Gutiérrez, Lizeth Guadalupe Campos-Múzquiz, Sandra Cecilia Esparza-González, Raúl Rodríguez-Herrera, Lissethe Palomo-Ligas   +6 more
doaj   +1 more source

Structural modifications of quinoline-based antimalarial agents: Recent developments

Journal of Pharmacy and Bioallied Sciences, 2010
Antimalarial drugs constitute a major part of antiprotozoal drugs and have been in practice for a long time. Antimalarial agents generally belong to the class of quinoline which acts by interfering with heme metabolism. The recent increase in development
Sandhya Bawa, Suresh Kumar, Sushma Drabu, Rajiv Kumar   +3 more
doaj   +1 more source

An impact of the combined drug containing antimicrobial, antiprotozoal, antifungal and glucocorticoid agents on local immunity in women with bacterial vaginosis and non-specific vaginitis

, 2021
O. M. Bokach, M. S. Murasheva, M. S. Selkova, Kseniia V. Storozheva, S. V. Chepanov, S. А. Selkov   +5 more
openalex   +2 more sources

Flavonoids from Piper Species as Promising Antiprotozoal Agents against Giardia intestinalis. Structure-Activity Relationship and Drug-Likeness Studies. [PDF]

Pharmaceuticals (Basel), 2022
Ticona JC, Bilbao-Ramos P, Amesty Á, Flores N, Dea-Ayuela MA, Bazzocchi IL, Jiménez IA.   +6 more
europepmc   +1 more source

Modulation of the Mechanism of Action of the 2-Arylquinazoline Through Functionalization at 4-Position: A Strategy to Access to a Potent Antiprotozoal Agent

, 2023
Angel H. Romero, Elena Paola AGUILERA LÓPEZ, Lourdes Gotopo, Gustavo Cabrera, Belén Dávila, Hugo Cerecetto Meyer   +5 more
openalex   +1 more source