Results 51 to 60 of about 7,929 (164)

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly, Abdulmajeed F. Alrefaei, Hossa F. Alshareef, Samar J. Almehmadi, Fatimah A. Alotaibi, Nadiyah M. Alshammari, Manal S. Ebaid, Hanadi A. Katouah   +7 more
wiley   +1 more source

Analogs of 5-methylthioribose, a novel class of antiprotozoal agents [PDF]

Antimicrobial Agents and Chemotherapy, 1988
Since drug resistance and toxicity limit the use of available antiprotozoal agents, it is important that new drugs be developed as soon as possible. In this study, the method by which several protozoa degrade 5'-methylthioadenosine (MTA) was shown to differ from MTA catabolism in human cells.
M K, Riscoe, A J, Ferro, J H, Fitchen
openaire   +2 more sources

Synthesis of Oxazolyl‐Piperidines Bearing a Quaternary Stereocenter Through a Multicomponent Reaction Involving α‐Isocyanoacetates and Piperidones

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Straightforward access to oxazole‐containing piperidines through a multicomponent reaction from α‐isocyanoacetates is described. By expanding the reactivity of these a‐isocyanoacetates from aldehydes to ketones, this process efficiently delivers oxazolyl‐piperidines bearing a quaternary stereocenter as valuable scaffolds relevant to drug discovery. The
Roshan Chandrakant Kajare, Gilles Argouarch, Nicolas Gouault, Claudia Lalli   +3 more
wiley   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, Volume 38, Issue 34, 17 June 2026.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Synthesis of Possible Antiprotozoal Agents

, 1984
Department of Chemical Technology, University College of Science, 92, Acharya P. C. Road, Calcutta-700 009 Manuscript received 3 December 1982, revised 30 November 1983, accepted 26 May 1984 Synthesis of Possible Antiprotozoal ...
B. R. SARKAR, D. GHOSH, B. C. PATHAK
openaire   +2 more sources

The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

Molecules, 2016
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year
Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai, Kelly Chibale   +3 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Nutritional Composition, Therapeutic Benefits, and Functional Food Potential of Coleus amboinicus: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Coleus amboinicus is a nutrient‐rich herb containing vitamins (A‐, C‐, B‐complex), minerals (Ca, Mg, Fe, K), dietary fiber, and potent bioactives such as rosmarinic acid, quercetin, thymol, and carvacrol. These compounds contribute to antioxidant, anti‐inflammatory, antimicrobial, prebiotic, and cardioprotective benefits.
Shani Upadhyay, Rakesh Verma, Shikha Gupta   +2 more
wiley   +1 more source

Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Molecules
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra   +7 more
doaj   +1 more source

Graph‐Theoretical Approach for Predicting Physicochemical Properties of Stiff‐Person Syndrome Drugs

ChemistryOpen, Volume 15, Issue 6, June 2026.
Graph‐theoretical descriptors derived from M‐polynomials are integrated with quantitative structure–property relationship modeling and machine learning to uncover structure–property relationships of drugs used in stiff‐person syndrome. Strong correlations between degree‐based topological indices and key physicochemical properties are revealed ...
Jabbar Ali, Yasir Ali, Maher Ali Malik, Yilun Shang   +3 more
wiley   +1 more source