Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles
ChemistryOpen, 2021 A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa +9 more
doaj +1 more source
Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana [PDF]
, 2013 Leishmaniasis is a worldwide parasitic disease, caused by monoflagellate parasites of the genus Leishmania. In the search for more effective agents against these parasites, the identification of molecular targets has been attempted to ensure the ...
Barrera, Patricia Andrea +7 more
core +3 more sources
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö +8 more
wiley +1 more source
Jonathan L. Vennerstrom: I Was Standing on the Shoulders of Giants
CHIMIA, 2023 Jonathan L. Vennerstrom grew up in Ethiopia, where he was witness to the effects of leprosy and other infectious diseases of poverty on the local population.
Lukas Meier
doaj +1 more source
The in vitro and in vivo testing of chemotherapeutic agents against pathogenic free living amebae : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University, Palmerston North, New Zealand. [PDF]
, 1980 During the last ten years, there has been an increasing awareness of sporadic cases of Primary Amoebic Meningo-encephalitis (PAM) affecting primarily younger age groups and appearing in an acute fulminant form. The earliest positive case (Willaert, 1974)
Elmsly, Christopher John
core
Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena [PDF]
, 2012 A series 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines (43 compounds), some of which are epidermal growth 22 factor tyrosine kinase inhibitors, were tested for their protozoal toxicity using an environmental Tetrahy- 23 mena strain as model organism.
Charnock, Colin +3 more
core +4 more sources
Analogs of 5-methylthioribose, a novel class of antiprotozoal agents [PDF]
Antimicrobial Agents and Chemotherapy, 1988 Since drug resistance and toxicity limit the use of available antiprotozoal agents, it is important that new drugs be developed as soon as possible. In this study, the method by which several protozoa degrade 5'-methylthioadenosine (MTA) was shown to differ from MTA catabolism in human cells.
M K, Riscoe, A J, Ferro, J H, Fitchen
openaire +2 more sources
Equine protozoal myeloencephalitis—Presentation and progression
Equine Veterinary Education, Volume 38, Issue 3, Page 132-134, March 2026.Summary Equine protozoal myeloencephalitis (EPM) remains one of the most frequently diagnosed neurological disorders of horses in North America, caused primarily by Sarcocystis neurona and less commonly Neospora hughesi. The clinical presentation is highly variable due to multifocal involvement of both grey and white matter, with asymmetric ataxia and ...
S. Austin, S. Gray
wiley +1 more source
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines [PDF]
, 2015 We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability.
Artigas, Albert +8 more
core +2 more sources
Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase [PDF]
Proceedings of the National Academy of Sciences, 1996 A novel fungal metabolite, apicidin [cyclo( N - O -methyl- l -tryptophanyl- l -isoleucinyl- d -pipecolinyl- l -2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity
S J, Darkin-Rattray +14 more
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