Results 61 to 70 of about 7,929 (164)

Design, Synthesis, In Vitro and In Silico Biological Evaluation of New Pyridine-2,5-Dicarboxylates Esters Bearing Natural Source Fragments as Anti-Trypanosomatid Agents

Pharmaceutics
Background: Chagas disease and leishmaniasis remain public health concerns. Despite the existence of approved medications for the treatment of these diseases, most patients discontinue treatment due to long drug regimens and/or the severe side effects of
Luis M. Sánchez-Palestino, Adriana Moreno-Rodríguez, Diana V. Navarrete-Carriola, Marlet Martínez-Archundia, Marhian López-Vargas, Liliana Argueta-Figueroa, Lenci K. Vázquez-Jiménez, Alma D. Paz-González, Eyra Ortiz-Pérez, Michael P. Doyle, Gildardo Rivera   +10 more
doaj   +1 more source

Repositioning Imipramine for Antiparasitic Effects Against Giardia lamblia

Drugs and Drug Candidates
Background/Objectives: Giardia lamblia is an intestinal protozoan responsible for giardiasis, a globally prevalent parasitic disease. Current therapeutic options, including nitroimidazoles and benzimidazoles, have increasing treatment failures due to ...
Xareni Zinereth Herrera-Valero, Sendar Daniel Nery-Flores, Filiberto Gutiérrez-Gutiérrez, Lizeth Guadalupe Campos-Múzquiz, Sandra Cecilia Esparza-González, Raúl Rodríguez-Herrera, Lissethe Palomo-Ligas   +6 more
doaj   +1 more source

Antileishmanial potential of medicinal plants: A global systematic and meta-analytic review of in vitro studies [PDF]

Journal of HerbMed Pharmacology
Introduction: Leishmaniasis is a major global health challenge with limited treatment options and rising drug resistance. Medicinal plants, traditionally used in many regions, offer a promising source of new antileishmanial agents.
Mohammed-Yassine Takzima, Mohamed Echchakery, Mounia Amane, Mohamed Hafidi, Loubna El fels   +4 more
doaj   +1 more source

Surveillance of Drug Residue Profiles in Gallus gallus domesticus (Silkie Chickens) in Taiwan

Animals
Veterinary drugs are extensively utilized in poultry farming for purposes such as disease prevention, disease treatment, and feed efficiency enhancement. However, the application of these drugs can lead to unacceptable residues in edible products.
Chiao-Hsu Ke, Jr-Wei Chen, Chen-Si Lin
doaj   +1 more source

48: DRUG SCREENING OF NOVEL ANTIPROTOZOAL AGENTS AGAINST GIARDIA DUODENALIS

Journal of Global Antimicrobial Resistance, 2022
B. Knight, R. Abraham, S.W. Page, S. Abraham   +3 more
doaj   +1 more source

Structural modifications of quinoline-based antimalarial agents: Recent developments

Journal of Pharmacy and Bioallied Sciences, 2010
Antimalarial drugs constitute a major part of antiprotozoal drugs and have been in practice for a long time. Antimalarial agents generally belong to the class of quinoline which acts by interfering with heme metabolism. The recent increase in development
Sandhya Bawa, Suresh Kumar, Sushma Drabu, Rajiv Kumar   +3 more
doaj   +1 more source

Flavonoids from Piper Species as Promising Antiprotozoal Agents against Giardia intestinalis. Structure-Activity Relationship and Drug-Likeness Studies. [PDF]

Pharmaceuticals (Basel), 2022
Ticona JC, Bilbao-Ramos P, Amesty Á, Flores N, Dea-Ayuela MA, Bazzocchi IL, Jiménez IA.   +6 more
europepmc   +1 more source

Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines

Frontiers in Chemistry
Quinolines are well-established scaffolds in drug discovery and form the core of many FDA-approved medicines. Among their reduced analogues, hexahydroquinolines (HHQs) have gained increasing attention due to their structural adaptability and broad ...
Gbolahan O. Oduselu, Gbolahan O. Oduselu, Rhoda O. Olatuyi, Omowunmi O. Fatoki, Damilola S. Bodun, Promise E. Sunday, Wellington Oyibo, Olayinka O. Ajani   +7 more
doaj   +1 more source

Bio-Assay Guided Isolation of Germacranes with Anti-Protozoan

Natural Product Communications, 2007
In the course of our search for antiprotozoal agents from terrestrial plants, three new germacranes 1, 2 and 3, together with the well known sesquiterpene lactones parthenolide (4) and costunolide (5), were isolated from Magnolia sororum using bioassay ...
Luis A. Sánchez, Zeuz Capitan, Luz I. Romero, Eduardo Ortega-Barría, William H. Gerwick, Luis Cubilla-Rios   +5 more
doaj   +1 more source

Editorial: Cutaneous Leishmaniasis: Exploring Pathogenesis and Immunomodulatory Approaches

Frontiers in Cellular and Infection Microbiology, 2022
Wander Rogério Pavanelli, Izabel Galhardo Demarchi   +1 more
doaj   +1 more source