Results 81 to 90 of about 5,274,206 (218)
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.Subclinical haemoprotozoan infection disrupts RBC integrity, and that leads to decreased Hb level and excess free iron in plasma. That subsequently impairs ovarian follicular development and thereby builds up a mechanistic link to reproductive failure in dairy cattle.
Most. Mousumi Akter +9 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly +7 more
wiley +1 more source
The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases
Molecules, 2016 Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year
Peter Mubanga Cheuka +3 more
doaj +1 more source
European journal of medicinal chemistry, 2017 A new series of N-substituted 2-pyrazolines 9a-f, 10a-f, 11a-f, 12a-f and 13a-f were obtained from the cyclocondensation reaction of [(7-chloroquinolin-4-yl)amino]chalcones 8a-f with hydrazine hydrate and its derivatives.
Jonathan Ramírez-Prada +9 more
semanticscholar +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.Straightforward access to oxazole‐containing piperidines through a multicomponent reaction from α‐isocyanoacetates is described. By expanding the reactivity of these a‐isocyanoacetates from aldehydes to ketones, this process efficiently delivers oxazolyl‐piperidines bearing a quaternary stereocenter as valuable scaffolds relevant to drug discovery. The
Roshan Chandrakant Kajare +3 more
wiley +1 more source
Evaluation of the in vitro [PDF]
, 2015 Trypanosomiasis is a neglected tropical disease with complex clinical manifestations, tedious diagnosis, and difficult treatments. The drugs available for the treatment of this endemic disease are old, expensive, and associated with other problems ...
Lai, Daowan +13 more
core +2 more sources
, 2022 Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Cristina Fonseca-Berzal (12124843) +13 more
core +1 more source
MoleculesTrypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez +7 more
doaj +1 more source
PharmaceuticsBackground: Chagas disease and leishmaniasis remain public health concerns. Despite the existence of approved medications for the treatment of these diseases, most patients discontinue treatment due to long drug regimens and/or the severe side effects of
Luis M. Sánchez-Palestino +10 more
doaj +1 more source
Repositioning Imipramine for Antiparasitic Effects Against Giardia lamblia
Drugs and Drug CandidatesBackground/Objectives: Giardia lamblia is an intestinal protozoan responsible for giardiasis, a globally prevalent parasitic disease. Current therapeutic options, including nitroimidazoles and benzimidazoles, have increasing treatment failures due to ...
Xareni Zinereth Herrera-Valero +6 more
doaj +1 more source