Results 31 to 40 of about 14,028 (214)

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

Novel Formula of Antiprotozoal Mixtures

Antibiotics, 2022
Antimicrobial resistance (AMR) is becoming more common in both bacteria and pathogenic protozoa. Therefore, new solutions are being sought as alternatives to currently used agents.
Hubert Iwiński, Jacek Łyczko, Henryk Różański, Antoni Szumny   +3 more
doaj   +1 more source

In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae [PDF]

, 2018
Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which
Cebrero Cangueiro, Tania, Cordero Matia, María Elisa, Labrador Herrera, Gema, Smani, Younes, Álvarez Marín, Rocío   +4 more
core   +1 more source

Antiprotozoal Nor-Triterpene Alkaloids from Buxus sempervirens L.

Antibiotics, 2021
Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for new antiprotozoal agents.
Lara U. Szabó, Marcel Kaiser, Pascal Mäser, Thomas J. Schmidt   +3 more
doaj   +1 more source

In vitro evaluation of the amoebicidal activity of rosemary (Rosmarinus officinalis L.) and cloves (Syzygium aromaticum L. Merr. & Perry) essential oils against Acanthamoeba polyphaga trophozoites [PDF]

, 2019
Several species of the genus Acanthamoeba cause human diseases. Treatment of infections involves various problems, emphasising the need to develop alternative antiprotozoal agents.
Anacarso, Immacolata, Bondi, Moreno, Condò, Carla, de Niederhäusern, Simona, Iseppi, Ramona, Messi, Patrizia, Sabia, Carla   +6 more
core   +1 more source

Antiprotozoal Activity Against Entamoeba histolytica of Flavonoids Isolated from Lippia graveolens Kunth

Molecules, 2020
Amebiasis caused by Entamoeba histolytica is nowadays a serious public health problem worldwide, especially in developing countries. Annually, up to 100,000 deaths occur across the world.
Ramiro Quintanilla-Licea, Javier Vargas-Villarreal, María Julia Verde-Star, Verónica Mayela Rivas-Galindo, Ángel David Torres-Hernández   +4 more
doaj   +1 more source

Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues

Molecules, 2021
Betulinic acid (BA, 3β-hydroxy-lup-20(29)-en-28-oic acid) is a pentacyclic triterpene acid present predominantly in Betula ssp. (Betulaceae) and is also widely spread in many species belonging to different plant families.
André Barreto Cunha, Ronan Batista, María Ángeles Castro, Jorge Mauricio David   +3 more
doaj   +1 more source

New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity [PDF]

, 2013
A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1. The dicationic diphenyl compounds exhibited the best activities with IC50 values against
Brun, R., Dardonville, Christophe, García, Rory Nelson, Kaiser, M., Nguyen, Binh, Rodríguez, F., Rozas, Isabel, Wilson, W. David   +7 more
core   +2 more sources

Furanocoumarins from Ruta chalepensis with Amebicide Activity

Molecules, 2021
Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries.
Aldo Fabio Bazaldúa-Rodríguez, Ramiro Quintanilla-Licea, María Julia Verde-Star, Magda Elizabeth Hernández-García, Javier Vargas-Villarreal, Jesús Norberto Garza-González   +5 more
doaj   +1 more source

Activity of benzimidazoles against Dientamoeba fragilis (Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance [PDF]

, 2014
Recently, Dientamoeba fragilis has emerged as a significant and common enteropathogen. The majority of patients with dientamoebiasis present with gastrointestinal complaints and chronic symptoms are common. Numerous studies have successfully demonstrated
Barratt, JLN, Ellis, J, Harkness, JT, Marriott, D, Roberts, T, Stark, D   +5 more
core   +1 more source