Novel Formula of Antiprotozoal Mixtures
Antibiotics, 2022 Antimicrobial resistance (AMR) is becoming more common in both bacteria and pathogenic protozoa. Therefore, new solutions are being sought as alternatives to currently used agents.
Hubert Iwiński +3 more
doaj +2 more sources
Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum. [PDF]
Chem BiodiversDicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
de Freitas CS +9 more
europepmc +2 more sources
Antiprotozoal Nor-Triterpene Alkaloids from Buxus sempervirens L. [PDF]
Antibiotics, 2021 Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for new antiprotozoal agents.
Lara U. Szabó +3 more
doaj +2 more sources
Advanced polymeric metal/metal oxide bionanocomposite using seaweed Laurencia dendroidea extract for antiprotozoal, anticancer, and photocatalytic applications [PDF]
PeerJ, 2023 Background Biosynthesized nanoparticles are gaining popularity due to their distinctive biological applications as well as bioactive secondary metabolites from natural products that contribute in green synthesis.
Musarat Amina +4 more
doaj +2 more sources
Medicinal plants with antileishmanial activity on parasites responsible for new-world cutaneous leishmaniasis. A systematic review 2018-2022 [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Cutaneous leishmaniasis is a disease of public health importance; treatment is based on the use of pentavalent antimonials with high toxicity and low efficacy; therefore, it´s necessary to search for therapeutic alternatives derived from natural
Yenny Y. Lozano +4 more
doaj +1 more source
Scientific Reports, 2022 Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen +13 more
doaj +1 more source
Asian Journal of Chemistry, 2023 Metallodrugs have been extensively used in modern research to design and synthesize new core drug molecules. In search of new leads in protozoal chemotherapy, we have synthesized novel ferrocene-substituted pyrimidine-based organometallic compounds and ...
Humaira Parveen +4 more
semanticscholar +1 more source
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]
, 2008 Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L. +4 more
core +4 more sources
Discovery of antiprotozoal compounds from medicinal plants [PDF]
, 2014 Tropical parasitic diseases such as malaria, human African trypanosomiasis, chagas disease, and leishmaniasis affect hundreds of millions of people worldwide and have devastating consequences.
Hata, Yoshie
core +1 more source
New hydrophilic riminophenazines as potent antiprotozoal agents [PDF]
, 2019 Malaria and leishmaniasis are life-threatening human parasitosis caused by protozoa-infected insect vectors. In most of affected countries, the expansive and hazardous therapies available to fight protozoan infections are generally harmed by the spread ...
Ivan Bassanini +3 more
core +2 more sources