Results 11 to 20 of about 5,274,206 (218)

Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents [PDF]

European Journal of Medicinal Chemistry, 2020
Malaria and tuberculosis are still among the leading causes of death in low-income countries. The 1,4-naphthoquinone (NQ) scaffold can be found in a variety of anti-infective agents.
Franz Bucar, Armin Presser, Marcel Kaiser   +2 more
exaly   +7 more sources

New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation [PDF]

Journal of Chemistry, 2021
Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3 ...
Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I. A. Mohamed, Shabana I. Khan, Babu L. Tekwani, Amar G Chittiboyina, Ikhlas A Khan, Tarfah Al-Warhi, Nada Aljaeed, Ohoud J. Alotaibi, Abdulsalam A. M. Alkhaldi, Heba A. H. Elshemy   +12 more
doaj   +4 more sources

Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents [PDF]

Archiv der Pharmazie
Geraniol, a primary component of several essential oils, has been associated with broad‐spectrum antiprotozoal activities, although moderate to weak. This study primarily concentrated on the synthesis of hydrazinated geraniol derivatives as potential ...
J. Jooste, Lesetja J. Legoabe, Kayhan Ilbeigi, G. Caljon, Richard M. Beteck   +4 more
semanticscholar   +8 more sources

Dicationic phenyl-2,2′-bichalcophenes and analogues as antiprotozoal agents [PDF]

Bioorganic and Medicinal Chemistry, 2011
A series of phenyl-2,2'-bichalcophene diamidines 1a-h were synthesized from the corresponding dinitriles either via a direct reaction with LiN(TMS)₂, followed by deprotection with ethanolic HCl or through the bis-O-acetoxyamidoxime followed by hydrogenation in acetic acid and EtOH over Pd-C.
W David Wilson, Mohamed A Ismail, Tanja Wenzler   +2 more
exaly   +7 more sources

Flavonoids from Piper Species as Promising Antiprotozoal Agents against Giardia intestinalis. Structure-Activity Relationship and Drug-Likeness Studies. [PDF]

Pharmaceuticals (Basel), 2022
Diarrhea diseases caused by the intestinal protozoan parasite Giardia intestinalis are a major global health burden. Moreover, there is an ongoing need for novel anti-Giardia drugs due to drawbacks with currently available treatments.
Ticona JC, Bilbao-Ramos P, Amesty Á, Flores N, Dea-Ayuela MA, Bazzocchi IL, Jiménez IA.   +6 more
europepmc   +2 more sources

A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents. [PDF]

J Am Chem Soc
On the basis of a streamlined route to the pyrroloiminoquinone (PIQ) core, we made 16 natural products spread across four classes of biosynthetically related alkaloid natural products, and multiple structural analogs, all in ≤8 steps longest linear ...
Barnes GL, Magann NL, Perrotta D, Hörmann FM, Fernandez S, Vydyam P, Choi JY, Prudhomme J, Neal A, Le Roch KG, Ben Mamoun C, Vanderwal CD.   +11 more
europepmc   +2 more sources

Caffeic Acid Phosphanium Derivatives: Potential Selective Antitumor, Antimicrobial and Antiprotozoal Agents. [PDF]

Int J Mol Sci
Caffeic acid (CA) is one of the most abundant natural compounds present in plants and has a broad spectrum of beneficial pharmacological activities. However, in some cases, synthetic derivation of original molecules can expand their scope.
Lukáč M, Slobodníková L, Mrva M, Dušeková A, Garajová M, Kello M, Šebová D, Pisárčik M, Kojnok M, Vrták A, Kurin E, Bittner Fialová S.   +11 more
europepmc   +2 more sources

Towards broadspectrum antiprotozoal agents

ARKIVOC, 2003
Since the market for antiparasitic drugs is in poor Third World countries, innovative and cost effective approaches to antiparasite drug discovery and development are urgently needed. Development of broadspectrum antiprotozoal agents acting against multiple protozoan parasites offers numerous advantages in addressing the challenges inherent in the ...
Kelly Chibale
doaj   +3 more sources

Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. [PDF]

Evid Based Complement Alternat Med, 2016
Leishmaniasis and Chagas disease are neglected parasitic diseases endemic in developing countries; efforts to find new therapies remain a priority. Calcium channel blockers (CCBs) are drugs in clinical use for hypertension and other heart pathologies ...
Reimão JQ, Mesquita JT, Ferreira DD, Tempone AG, Tempone AG.   +4 more
europepmc   +2 more sources

Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism

ChemMedChem, 2020
Leishmania and Trypanosoma parasites are responsible for the challenging neglected tropical diseases leishmaniases, Chagas disease, and human African trypanosomiasis, which account for up to 40,000 deaths annually mainly in developing countries.
Roberta Costi, Francesco Saccoliti, Roberto di Santo   +2 more
exaly   +2 more sources