Results 11 to 20 of about 7,929 (164)

Dicationic phenyl-2,2′-bichalcophenes and analogues as antiprotozoal agents [PDF]

Bioorganic and Medicinal Chemistry, 2011
A series of phenyl-2,2'-bichalcophene diamidines 1a-h were synthesized from the corresponding dinitriles either via a direct reaction with LiN(TMS)₂, followed by deprotection with ethanolic HCl or through the bis-O-acetoxyamidoxime followed by hydrogenation in acetic acid and EtOH over Pd-C.
W David Wilson, Mohamed A Ismail, Tanja Wenzler   +2 more
exaly   +7 more sources

Quinolines: the role of substitution site in antileishmanial activity [PDF]

Frontiers in Chemistry
Leishmaniasis is one of the most widespread parasitic diseases in the world, primarily affecting the poorest and most vulnerable populations. The development of new therapeutic agents that are more efficient, safe, and selective remains a challenge.
Orlando G. Elso, Guadalupe García Liñares   +1 more
doaj   +2 more sources

Structure−Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents [PDF]

ChemMedChem, 2020
Freddy Alexander Bernal, Bernhard Wunsch, Marcel Kaiser   +2 more
exaly   +2 more sources

Towards broadspectrum antiprotozoal agents

ARKIVOC, 2003
Since the market for antiparasitic drugs is in poor Third World countries, innovative and cost effective approaches to antiparasite drug discovery and development are urgently needed. Development of broadspectrum antiprotozoal agents acting against multiple protozoan parasites offers numerous advantages in addressing the challenges inherent in the ...
Kelly Chibale
doaj   +3 more sources

Advanced polymeric metal/metal oxide bionanocomposite using seaweed Laurencia dendroidea extract for antiprotozoal, anticancer, and photocatalytic applications [PDF]

PeerJ, 2023
Background Biosynthesized nanoparticles are gaining popularity due to their distinctive biological applications as well as bioactive secondary metabolites from natural products that contribute in green synthesis.
Musarat Amina, Nawal M. Al Musayeib, Seham Alterary, Maha F. El-Tohamy, Samira A. Alhwaiti   +4 more
doaj   +2 more sources

Medicinal plants with antileishmanial activity on parasites responsible for new-world cutaneous leishmaniasis. A systematic review 2018-2022 [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Cutaneous leishmaniasis is a disease of public health importance; treatment is based on the use of pentavalent antimonials with high toxicity and low efficacy; therefore, it´s necessary to search for therapeutic alternatives derived from natural
Yenny Y. Lozano, Sara E. Giraldo, Angela C. Zapata, Jesús E. Escobar, Ruth M. Sánchez   +4 more
doaj   +1 more source

Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach

Scientific Reports, 2022
Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen, Evren Tileklioglu, Edna Bode, Harun Cimen, Hatice Ertabaklar, Derya Ulug, Sema Ertug, Sebastian L. Wenski, Mustapha Touray, Canan Hazir, Duygu Kaya Bilecenoglu, Ibrahim Yildiz, Helge B. Bode, Selcuk Hazir   +13 more
doaj   +1 more source

New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation

Journal of Chemistry, 2021
Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3 ...
Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I. A. Mohamed, Shabana I. Khan, Babu L. Tekwani, Amar G Chittiboyina, Ikhlas A Khan, Tarfah Al-Warhi, Nada Aljaeed, Ohoud J. Alotaibi, Abdulsalam A. M. Alkhaldi, Heba A. H. Elshemy   +12 more
doaj   +1 more source

Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review

Pathogens, 2021
Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ...
Zainab U. Abdullahi, Salihu S. Musa, Daihai He, Umar M. Bello   +3 more
doaj   +1 more source

Antiprotozoal Activity against Entamoeba histolytica of Plants Used in Northeast Mexican Traditional Medicine. Bioactive Compounds from Lippia graveolens and Ruta chalepensis

Molecules, 2014
Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries.
Ramiro Quintanilla-Licea, Benito David Mata-Cárdenas, Javier Vargas-Villarreal, Aldo Fabio Bazaldúa-Rodríguez, Isvar Kavimngeles-Hernández, Jesús Norberto Garza-González, Magda Elizabeth Hernández-García   +6 more
doaj   +1 more source