Results 11 to 20 of about 8,093 (191)

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents [PDF]

Molecules, 2019
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis ...
Anastasia L. Khandazhinskaya, Elena S. Matyugina, Pavel N. Solyev, Maggie Wilkinson, Karen W. Buckheit, Robert W. Buckheit, Larisa N. Chernousova, Tatiana G. Smirnova, Sofya N. Andreevskaya, Khalid J. Alzahrani, Manal J. Natto, Sergey N. Kochetkov, Harry P. de Koning, Katherine L. Seley-Radtke   +13 more
doaj   +5 more sources

Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents

European Journal of Medicinal Chemistry, 2020
Malaria and tuberculosis are still among the leading causes of death in low-income countries. The 1,4-naphthoquinone (NQ) scaffold can be found in a variety of anti-infective agents. Herein, we report an optimised, high yield process for the preparation of various 2-arylnaphthoquinones by a palladium-catalysed Suzuki reaction. All synthesised compounds
Wolfgang Schuehly, Robert Saf, Julia Solnier   +2 more
exaly   +6 more sources

New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation [PDF]

Journal of Chemistry, 2021
Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3 ...
Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I. A. Mohamed, Shabana I. Khan, Babu L. Tekwani, Amar G Chittiboyina, Ikhlas A Khan, Tarfah Al-Warhi, Nada Aljaeed, Ohoud J. Alotaibi, Abdulsalam A. M. Alkhaldi, Heba A. H. Elshemy   +12 more
doaj   +2 more sources

Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi [PDF]

Pharmaceutics, 2023
Chagas disease is a neglected tropical disease that affects more than 8 million people. Although there are therapies against this disease, the search for new drugs is important because the current treatments show limited effectiveness and high toxicity ...
Mariana C. Pagotti, Herbert J. Dias, Ana Carolina B. B. Candido, Thaís A. S. Oliveira, Alexandre Borges, Nicoli D. Oliveira, Carla D. Lopes, Renato P. Orenha, Renato L. T. Parreira, Antônio E. M. Crotti, Lizandra G. Magalhães   +10 more
doaj   +2 more sources

Analogs of 5-methylthioribose, a novel class of antiprotozoal agents [PDF]

Antimicrobial Agents and Chemotherapy, 1988
Since drug resistance and toxicity limit the use of available antiprotozoal agents, it is important that new drugs be developed as soon as possible. In this study, the method by which several protozoa degrade 5'-methylthioadenosine (MTA) was shown to differ from MTA catabolism in human cells.
Michael K. Riscoe, A J Ferro, J H Fitchen   +2 more
openalex   +4 more sources

New antiprotozoal agents: Their synthesis and biological evaluations

Bioorganic & Medicinal Chemistry Letters, 2013
Here we report identification of new lead compounds based on quinoline and indenoquinolines with variable side chains as antiprotozoal agents. Quinolines 32, 36 and 37 (Table 1) and indenoquinoline derivatives 14 and 23 (Table 2) inhibit the in vitro growth of the Trypanosoma cruzi, Trypanosoma brucei, Trypanosoma brucei rhodesiense subspecies and ...
Ram Shankar Upadhayaya, Shailesh S. Dixit, András Földesi, Jyoti Chattopadhyaya   +3 more
openalex   +4 more sources

Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase [PDF]

Proceedings of the National Academy of Sciences, 1996
A novel fungal metabolite, apicidin [cyclo( N - O -methyl- l -tryptophanyl- l -isoleucinyl- d -pipecolinyl- l -2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity
Sandra J. Darkin‐Rattray, Anne Gurnett, Robert W. Myers, Paula M. Dulski, Tami M. Crumley, John Allocco, Christine Cannova, Peter T. Meinke, Steven L. Colletti, Maria A. Bednarek, Sheo B. Singh, Michael Goetz, Anne W. Dombrowski, Jon D. Polishook, Dennis M. Schmatz   +14 more
openalex   +4 more sources

Triazole-Functionalized Jatrophone Derivatives as Antiprotozoal Agents Against <i>Trypanosoma cruzi</i>: Synthesis, Biological Evaluation and Structure-Activity Relationships. [PDF]

Pharmaceuticals (Basel)
Pertino MW, Carreño Gonzalez P, Venegas González C, Schmeda-Hirschmann G, Vega Gómez C, Rolón M, Rojas de Arias A.   +6 more
europepmc   +2 more sources

Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents [PDF]

Archiv der Pharmazie
AbstractGeraniol, a primary component of several essential oils, has been associated with broad‐spectrum antiprotozoal activities, although moderate to weak. This study primarily concentrated on the synthesis of hydrazinated geraniol derivatives as potential antiprotozoal agents.
Joelien Jooste, Lesetja J. Legoabe, Kayhan Ilbeigi, Guy Caljon, Richard M. Beteck   +4 more
openalex   +6 more sources

Volatile Compounds as Upcoming Antigiardial Agents: In Vitro Action of Carvacrol, Thymol and p-Cymene on Giardia lamblia Trophozoites [PDF]

Pharmaceutics
Background/Objectives: Carvacrol and thymol are monoterpenes present in phenolic-rich essential oils extracted from aromatic plants that exhibit antimicrobial activity.
Marisa Machado, Ana Silva, Rui Linhares, Carlos Cavaleiro, Maria C. Sousa   +4 more
doaj   +2 more sources