Results 11 to 20 of about 14,028 (214)

Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. [PDF]

Bioorg Med Chem, 2011
A series of phenyl-2,2'-bichalcophene diamidines 1a-h were synthesized from the corresponding dinitriles either via a direct reaction with LiN(TMS)₂, followed by deprotection with ethanolic HCl or through the bis-O-acetoxyamidoxime followed by hydrogenation in acetic acid and EtOH over Pd-C.
Ismail MA, Bialy SA, Brun R, Wenzler T, Nanjunda R, Wilson WD, Boykin DW.   +6 more
europepmc   +5 more sources

Volatile Compounds as Upcoming Antigiardial Agents: In Vitro Action of Carvacrol, Thymol and p-Cymene on Giardia lamblia Trophozoites [PDF]

Pharmaceutics
Background/Objectives: Carvacrol and thymol are monoterpenes present in phenolic-rich essential oils extracted from aromatic plants that exhibit antimicrobial activity.
Marisa Machado, Ana Silva, Rui Linhares, Carlos Cavaleiro, Maria C. Sousa   +4 more
doaj   +2 more sources

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents [PDF]

Molecules, 2019
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis ...
Anastasia L. Khandazhinskaya, Elena S. Matyugina, Pavel N. Solyev, Maggie Wilkinson, Karen W. Buckheit, Robert W. Buckheit, Larisa N. Chernousova, Tatiana G. Smirnova, Sofya N. Andreevskaya, Khalid J. Alzahrani, Manal J. Natto, Sergey N. Kochetkov, Harry P. de Koning, Katherine L. Seley-Radtke   +13 more
doaj   +4 more sources

Quinolines: the role of substitution site in antileishmanial activity [PDF]

Frontiers in Chemistry
Leishmaniasis is one of the most widespread parasitic diseases in the world, primarily affecting the poorest and most vulnerable populations. The development of new therapeutic agents that are more efficient, safe, and selective remains a challenge.
Orlando G. Elso, Guadalupe García Liñares   +1 more
doaj   +2 more sources

Advanced polymeric metal/metal oxide bionanocomposite using seaweed Laurencia dendroidea extract for antiprotozoal, anticancer, and photocatalytic applications [PDF]

PeerJ, 2023
Background Biosynthesized nanoparticles are gaining popularity due to their distinctive biological applications as well as bioactive secondary metabolites from natural products that contribute in green synthesis.
Musarat Amina, Nawal M. Al Musayeib, Seham Alterary, Maha F. El-Tohamy, Samira A. Alhwaiti   +4 more
doaj   +2 more sources

Medicinal plants with antileishmanial activity on parasites responsible for new-world cutaneous leishmaniasis. A systematic review 2018-2022 [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Cutaneous leishmaniasis is a disease of public health importance; treatment is based on the use of pentavalent antimonials with high toxicity and low efficacy; therefore, it´s necessary to search for therapeutic alternatives derived from natural
Yenny Y. Lozano, Sara E. Giraldo, Angela C. Zapata, Jesús E. Escobar, Ruth M. Sánchez   +4 more
doaj   +1 more source

Phytochemical and Biological Evaluation of Leaves, Stems, and Roots of Schinus weinmanniifolia Mart. Ex Engl. [PDF]

Chem Biodivers
Ethanolic extracts from leaves, stems, and roots of Schinus weinmanniifolia Mart. ex Engl. were evaluated for phytochemical composition and biological activities. The extracts exhibited antioxidant, photoprotective, and antimicrobial activity, without hemolytic effects or cytotoxicity at active concentrations. Syringic acid, epicatechin, and rutin were
Andrade J, de Almeida-Apolonio AA, Dantas FGDS, Santos JIDS, Sangalli A, Negri M, Ferreira DG, Cardoso CAL, de Castro TLA, Gomes ADSG, Bonono R, Fernandes L, Rodrigues ME, Henriques MCR, de Oliveira KMP.   +14 more
europepmc   +2 more sources

Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach

Scientific Reports, 2022
Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen, Evren Tileklioglu, Edna Bode, Harun Cimen, Hatice Ertabaklar, Derya Ulug, Sema Ertug, Sebastian L. Wenski, Mustapha Touray, Canan Hazir, Duygu Kaya Bilecenoglu, Ibrahim Yildiz, Helge B. Bode, Selcuk Hazir   +13 more
doaj   +1 more source

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]

, 2020
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel, Cardona G, Wilson I, Coa, Juan Carlos, Conesa Milián, Laura, Robledo, Sara M., Upegui Zapata, Yulieth Alexandra, Yepes, Andrés   +6 more
core   +1 more source

Coinfection of Leishmania (Viannia) braziliensis and Streptococcus pneumoniae in multiple cutaneous lesions [PDF]

, 2016
Key learning points Cutaneous leishmaniasis is the most common clinical disease caused by all the Leishmania species that are pathogenic to humans. Other bacterial coinfections of Leishmania lesions have been described, but this is the first report of ...
Chiapello, Laura Silvina, Cortes, Paulo R., De Petris, Carlos, Dib, David, Echenique, Jose Ricardo, Herrero, Mónica V., Nuncira, Carmen T.   +6 more
core   +6 more sources