Results 111 to 120 of about 7,929 (164)

Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives. [PDF]

ChemMedChem
Lusardi M, Basilico N, Iervasi E, Brullo C, Parapini S, Ponassi M, Rosano C, Spallarossa A.   +7 more
europepmc   +1 more source

A case report of primary amebic meningoencephalitis in a Chinese adult male. [PDF]

Parasitol Res
Kuang Y, Li Q, Li H, Guo Y, Wang J, Peng C, He P, Chen S, Nian S, Feng L.   +9 more
europepmc   +1 more source

Selective Modulation of Lipid Langmuir Monolayers by Methyl Dehydrodieugenol: Insights into Its Interaction with Compressibility-Modulating Lipid Interfaces for Antiprotozoal Applications. [PDF]

Langmuir
Berllini GT, G Gonçalves GE, Sales FS, Lago JHG, Caseli L.   +4 more
europepmc   +1 more source

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Antiprotozoal Agents from Plant Sources

Planta Medica, 1991
Protozoa are responsible for a number of serious tropical diseases including amoebiasis, leishmaniasis, malaria, and trypanosomiasis. New drugs are required for the treatment of these diseases and the potential of plants to produce new clinical agents is discussed.
Colin Wright, J David Phillipson, J Phillipson   +2 more
exaly   +4 more sources

Tinidazole: A nitroimidazole antiprotozoal agent

Clinical Therapeutics, 2005
Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
openaire   +2 more sources

Antiprotozoal Agents: An Overview

Anti-Infective Agents in Medicinal Chemistry, 2009
The therapy of parasitic diseases has relied, until recently, on the use of a very limited number of drugs, most of them of low efficacy, leading to side effects and in certain cases with high toxicity. This review focuses on the chemother- apy to treat diseases caused by Trypanosoma cruzi (Chagas' disease), Trypanosoma b.
C. Graebin, F. Uchoa, L. Bernardes, V. Campo, I. Carvalho, V. Eifler-Lima   +5 more
openaire   +1 more source

Saponins as Potential Antiprotozoal Agents

2021
The sphere of natural products is an abundant source for discovery of therapeutic drugs for the treatment of neglected parasitic diseases. Various classes of chemical substances displayed antiprotozoal activity, such as alkaloids, terpenoids, saponins, and flavonoids.
Ana Claudia F. Amaral, Aline de S. Ramos, José Luiz P. Ferreira, Maíra Martins H. de Almeida, Jefferson D. da Cruz, Danielle L. de Oliveira, Ana Clara B. Maria, Aimee A. de Oliveira, Igor A. Rodrigues, Jefferson R. de A. Silva   +9 more
openaire   +1 more source

Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents

European Journal of Medicinal Chemistry, 2020
Malaria and tuberculosis are still among the leading causes of death in low-income countries. The 1,4-naphthoquinone (NQ) scaffold can be found in a variety of anti-infective agents. Herein, we report an optimised, high yield process for the preparation of various 2-arylnaphthoquinones by a palladium-catalysed Suzuki reaction. All synthesised compounds
Franz Bucar, Armin Presser, Marcel Kaiser   +2 more
exaly   +5 more sources

Chemistry of Antiprotozoal Agents

1986
The search for agents useful for the prevention or cure of the protozoal diseases malaria and sleeping sickness was closely linked to the early development of medicinal chemistry (see Chapter 1). Unlike antibacterial agents, for which a few chemical structural classes exhibit a wide spectrum of biological activity, antiprotozoal activity exists in a ...
John C. Chabala, Max W. Miller
openaire   +1 more source

Antiprotozoal and Anthelmintic Agents

2018
Combination chemotherapy is commonly indicated for treatment of parasitic diseases and dictated by a requirement to combine the aim of effective chemotherapy with the wish to minimize emergence of drug resistance. Throughout the past few decades, the clinical pharmacokinetics and metabolism of many antiparasitic agents have been elucidated ...
Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom   +2 more
openaire   +1 more source