Results 151 to 160 of about 7,779 (200)

Antiprotozoal Agents: An Overview

Anti-Infective Agents in Medicinal Chemistry, 2009
The therapy of parasitic diseases has relied, until recently, on the use of a very limited number of drugs, most of them of low efficacy, leading to side effects and in certain cases with high toxicity. This review focuses on the chemother- apy to treat diseases caused by Trypanosoma cruzi (Chagas' disease), Trypanosoma b.
C. Graebin, F. Uchoa, L. Bernardes, V. Campo, I. Carvalho, V. Eifler-Lima   +5 more
openaire   +1 more source

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Bioorganic & Medicinal Chemistry, 2004
A series of biphenyl benzimidazoles diamidines 6a-i were synthesized from their respective diamidoximes, through the bis-O-acetoxyamidoxime followed by hydrogenation in glacial acetic acid/ethanol in the presence of Pd-C. The target compounds contain hydroxy and/or methoxy substituted 1,3-phenyl groups as the central spacer between the two amidino ...
Mohamed A, Ismail, Reto, Brun, Tanja, Wenzler, Farial A, Tanious, W David, Wilson, David W, Boykin   +5 more
openaire   +2 more sources

Antiprotozoal and Anthelmintic Agents

2018
Combination chemotherapy is commonly indicated for treatment of parasitic diseases and dictated by a requirement to combine the aim of effective chemotherapy with the wish to minimize emergence of drug resistance. Throughout the past few decades, the clinical pharmacokinetics and metabolism of many antiparasitic agents have been elucidated ...
Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom   +2 more
openaire   +1 more source

ChemInform Abstract: New Antiprotozoal Agents.

Chemischer Informationsdienst, 1976
AbstractDie Nitro‐Derivate (IV), (V) und (VI) von Diimidazo‐ [1,2‐a; 2′,l ′‐c]pyrazin und Diimidazol [1,2‐a; 2′, l′‐c][1,4]diazepin werden dargestellt und gegen Trichomonas vaginalis, Entamoeba histolytica und Giardia muris getestet.
PIERO MELLONI, DOMENICO FUSAR‐BASSINI, WILLY LOGEMANN, ANGELO FORGIONE, EMANUELE DRADI, IVO DE CARNERI, ALBERTA BIANCHI, FRANCA TRANE   +7 more
openaire   +1 more source

Novel Hydrophilic Riminophenazines as Potent Antiprotozoal Agents

ChemMedChem, 2019
AbstractSAR studies on a set of novel hydrophilic C‐2 aminopyridinyl riminophenazines bearing variously functionalized basic side chains at C‐3 were conducted. The novel compounds were evaluated for in vitro activity against two different species of Leishmania promastigotes, intramacrophage Leishmania amastigotes, chloroquine‐sensitive and chloroquine ...
Ivan Bassanini, Silvia Parapini, Nicoletta Basilico, Anna Sparatore   +3 more
openaire   +3 more sources

Chemistry of Antiprotozoal Agents

1986
The search for agents useful for the prevention or cure of the protozoal diseases malaria and sleeping sickness was closely linked to the early development of medicinal chemistry (see Chapter 1). Unlike antibacterial agents, for which a few chemical structural classes exhibit a wide spectrum of biological activity, antiprotozoal activity exists in a ...
John C. Chabala, Max W. Miller
openaire   +1 more source

Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents

Current Medicinal Chemistry, 2021
Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Together, they cause more than 500 million infections per year.
Antonio Moreno-Herrera, Sandra Cortez-Maya, Virgilio Bocanegra-Garcia, Bimal Krishna Banik, Gildardo Rivera   +4 more
openaire   +2 more sources

Histone Deacetylase: A Target for Antiproliferative and Antiprotozoal Agents

Current Medicinal Chemistry, 2001
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. It is well-established that in transcriptionally active chromatin, histones generally are hyperacetylated and ...
P T, Meinke, P, Liberator
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Assessing Antiprotozoal Agents

2009
Nitrogen metabolism in the rumen affects both the efficiency of ruminant production and the environmental impact of excreta from ruminant livestock production. Inefficient N retention by rumen microorganisms is compensated in production terms by feeding excessive amounts of dietary protein to the animal to meet required output levels.
openaire   +1 more source

Antifungal, antiprotozoal and antiviral agents

1989
In addition to bacterial disease many infections are caused by fungi, viruses and protozoa. Chemotherapy of these infections has been somewhat neglected because of the difficulty in designing safe and selective agents, but in recent years chemical ingenuity has led to some major breakthroughs.
T. J. Franklin, G. A. Snow
openaire   +1 more source