Results 21 to 30 of about 6,609 (178)

Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Marine Drugs, 2013
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser, Brent R. Copp, A. Norrie Pearce, Shen H. Tan, Cary F. C. Lam   +4 more
doaj   +1 more source

Novel Formula of Antiprotozoal Mixtures

Antibiotics, 2022
Antimicrobial resistance (AMR) is becoming more common in both bacteria and pathogenic protozoa. Therefore, new solutions are being sought as alternatives to currently used agents.
Hubert Iwiński, Jacek Łyczko, Henryk Różański, Antoni Szumny   +3 more
doaj   +1 more source

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]

, 2007
Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L., Ingram, Paul R., Muench, Stephen P., Rice, David W., Roberts, Craig W.   +4 more
core   +2 more sources

Trends in Nanoparticles for Leishmania Treatment: A Bibliometric and Network Analysis

Diseases, 2023
Leishmaniasis is a neglected tropical illness with a wide variety of clinical signs ranging from visceral to cutaneous symptoms, resulting in millions of new cases and thousands of fatalities reported annually.
Gabriel Mazón-Ortiz, Galo Cerda-Mejía, Eberto Gutiérrez Morales, Karel Diéguez-Santana, Juan M. Ruso, Humberto González-Díaz   +5 more
doaj   +1 more source

Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]

, 2013
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez, A. M. S. Mayer, N. Fusetani, TAGLIALATELA SCAFATI, ORAZIO   +3 more
core   +2 more sources

Recent Advances in the Discovery of Novel Antiprotozoal Agents

Molecules, 2019
Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people
Seong-Min Lee, Min-Sun Kim, Faisal Hayat, Dongyun Shin   +3 more
doaj   +1 more source

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines [PDF]

, 2015
We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability.
Artigas, Albert, Clos, Victòria, Gbedema, Stephen Y., Kelly, John M., Muñoz-Torrero López-Ibarra, Diego, Pérez Fernández, Belén, Sola, Irene, Taylor, Martin C., Wright, Colin W.   +8 more
core   +2 more sources

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity [PDF]

, 2013
A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1. The dicationic diphenyl compounds exhibited the best activities with IC50 values against
Brun, R., Dardonville, Christophe, García, Rory Nelson, Kaiser, M., Nguyen, Binh, Rodríguez, F., Rozas, Isabel, Wilson, W. David   +7 more
core   +2 more sources

Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles

ChemistryOpen, 2021
A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa, Samara Mendes de Souza Melo, Dr. Karlos Eduardo Pianoski, Julia Poletto, Mariellen Guilherme dosSantos, Dr. Michael Jackson Vieira da Silva, Dr. Danielle Lazarin‐Bidóia, Dr. Hélito Volpato, Prof. Sidnei Moura, Prof. Celso Vataru Nakamura   +9 more
doaj   +1 more source