Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents [PDF]
Archiv der PharmazieAbstractGeraniol, a primary component of several essential oils, has been associated with broad‐spectrum antiprotozoal activities, although moderate to weak. This study primarily concentrated on the synthesis of hydrazinated geraniol derivatives as potential antiprotozoal agents.
Joelien Jooste +4 more
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Advanced polymeric metal/metal oxide bionanocomposite using seaweed Laurencia dendroidea extract for antiprotozoal, anticancer, and photocatalytic applications [PDF]
PeerJ, 2023 Background Biosynthesized nanoparticles are gaining popularity due to their distinctive biological applications as well as bioactive secondary metabolites from natural products that contribute in green synthesis.
Musarat Amina +4 more
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Medicinal plants with antileishmanial activity on parasites responsible for new-world cutaneous leishmaniasis. A systematic review 2018-2022 [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Cutaneous leishmaniasis is a disease of public health importance; treatment is based on the use of pentavalent antimonials with high toxicity and low efficacy; therefore, it´s necessary to search for therapeutic alternatives derived from natural
Yenny Y. Lozano +4 more
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Scientific Reports, 2022 Natural products have been proven to be important starting points for the development of new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial compounds as secondary metabolites to compete with other organisms. Our study is
Sebnem Hazal Gulsen +13 more
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New antiprotozoal agents: Their synthesis and biological evaluations
Bioorganic & Medicinal Chemistry Letters, 2013 Here we report identification of new lead compounds based on quinoline and indenoquinolines with variable side chains as antiprotozoal agents. Quinolines 32, 36 and 37 (Table 1) and indenoquinoline derivatives 14 and 23 (Table 2) inhibit the in vitro growth of the Trypanosoma cruzi, Trypanosoma brucei, Trypanosoma brucei rhodesiense subspecies and ...
Ram Shankar Upadhayaya +3 more
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Furanocoumarins from Ruta chalepensis with Amebicide Activity
Molecules, 2021 Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries.
Aldo Fabio Bazaldúa-Rodríguez +5 more
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Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review
Pathogens, 2021 Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ...
Zainab U. Abdullahi +3 more
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Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. [PDF]
Bioorg Med Chem, 2011 A series of phenyl-2,2'-bichalcophene diamidines 1a-h were synthesized from the corresponding dinitriles either via a direct reaction with LiN(TMS)₂, followed by deprotection with ethanolic HCl or through the bis-O-acetoxyamidoxime followed by hydrogenation in acetic acid and EtOH over Pd-C.
Ismail MA +6 more
europepmc +5 more sources
Novel Formula of Antiprotozoal Mixtures
Antibiotics, 2022 Antimicrobial resistance (AMR) is becoming more common in both bacteria and pathogenic protozoa. Therefore, new solutions are being sought as alternatives to currently used agents.
Hubert Iwiński +3 more
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Trends in Nanoparticles for Leishmania Treatment: A Bibliometric and Network Analysis
Diseases, 2023 Leishmaniasis is a neglected tropical illness with a wide variety of clinical signs ranging from visceral to cutaneous symptoms, resulting in millions of new cases and thousands of fatalities reported annually.
Gabriel Mazón-Ortiz +5 more
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