Results 81 to 90 of about 6,609 (178)

Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery

Journal of Experimental Pharmacology, 2022
Leena Abdulaziz,1 Esraa Elhadi,1,2 Ejlal A Abdallah,3 Fadlalbaseer A Alnoor,4 Bashir A Yousef5 1Department of Pharmacology, Faculty of Pharmacy, Omdurman Islamic University, Khartoum, 14415, Sudan; 2Jiangsu Key Laboratory of Drug Screening, China ...
Abdulaziz L, Elhadi E, Abdallah EA, Alnoor FA, Yousef BA   +4 more
doaj  

Innovation in Green Extraction of Essential Oils From Medicinal Aromatic Plants and Their Nano‐Formulation With Potential Anti‐Respiratory Viruses Activities

eFood, Volume 6, Issue 6, December 2025.
Essential oils (EOs) from peppermint, thyme, eucalyptus, and lemongrass were extracted and characterized by GC‐MS, then combined and nano‐formulated. All extracts showed antiviral activity, with the nano‐mixture exhibiting the strongest effect against influenza A and SARS‐CoV‐2.
Sobhy Mohamed Mohsen, Mahmoud Mohamed Bahgat, Azza A. Amin, Amr M. Helal, Dina Nadeem Abd‐Elshafy, Sayed Saad Smuda, Mohammad Ali Hesarinejad, Tarek Gamal Abedelmaksoud   +7 more
wiley   +1 more source

Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study [PDF]

, 2013
Peer reviewedPublisher ...
Gow, Neil A R, Lee, Keunsook, Munro, Carol A, Pietro, Rosemeire C L R, Preechasuth, Kanya, Santos, Emerson, Severi, Juliana A, Souza-Moreira, Tatiana M, Vilegas, Wagner   +8 more
core   +4 more sources

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1889-1899, December 2025.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus [PDF]

, 2018
Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against ...
Andrew V Stachulski, Brian M Eklov, Chandrakala Pidathala, Eleanor C Row, Giuseppe Belardo, J Edward Semple, Jean-Francois Rossignol, La Frazia S, M Gabriella Santoro, Mazhar Iqbal, Neil G Berry, Paul M O'Neill, Podlogar BL, Rossignol JF, Rossignol JF, Sara Piacentini, Sarah A Allman, Simone La Frazia   +17 more
core   +1 more source

Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review

The Chemical Record, Volume 25, Issue 12, December 2025.
Indole and its derivatives represent a vital class of heterocycles with broad applications in pharmaceuticals, agrochemicals, and materials science. This review explores their applications, biosynthesis, key derivatives such as tryptophan, and presents an overview of both classical and modern synthetic methodologies, with a focus on sustainable ...
Raphael Silva Moratório de Moraes, Ana Beatriz Mestre Botelho, Gabriel Tavares de Almeida Pinto, Searitha Couto Rodrigues, Maria Tereza Miranda Martins, Deivid Lucas Alves Soares, Camille Cardoso Cruz, Aline de Almeida Pinto, Flaviana Rodrigues Fintelman Dias, Patricia Dias Fernandes, Anna Claudia Cunha   +10 more
wiley   +1 more source

Quantitative structure-activity relationship of some 1-benzylbenzimidazole derivatives as antifungal agents [PDF]

, 2007
In the present study, the antifungal activity of some 1-benzylbenzimidazole derivatives against yeast Saccharomyces cerevisiae was investigated. The tested benzimidazoles displayed in vitro antifungal activity and minimum inhibitory concentration (MIC ...
Barna Dijana J., Cvetković Dragoljub D., Podunavac-Kuzmanović Sanja O.   +2 more
core   +1 more source

Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Molecules
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra   +7 more
doaj   +1 more source

Mining Actinomycetes' Metabolomes and Genomes for Anti‐Phytophthora infestans Compounds

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
Using a comparative metabolomic and genomic approach on 63 actinomycetes, this study identified 75 compounds associated with the strains' ability to inhibit the late blight‐causing agent Phytophthora infestans. This study highlighted the promise of applying multi‐omics techniques on closely related strains differing in biological activity to pinpoint ...
Ola Abdelrahman, Quinn Coxon, Eliane Abou‐Mansour, Floriane L'Haridon, Laurent Falquet, Pierre‐Marie Allard, Laure Weisskopf   +6 more
wiley   +1 more source

Design, Synthesis, In Vitro and In Silico Biological Evaluation of New Pyridine-2,5-Dicarboxylates Esters Bearing Natural Source Fragments as Anti-Trypanosomatid Agents

Pharmaceutics
Background: Chagas disease and leishmaniasis remain public health concerns. Despite the existence of approved medications for the treatment of these diseases, most patients discontinue treatment due to long drug regimens and/or the severe side effects of
Luis M. Sánchez-Palestino, Adriana Moreno-Rodríguez, Diana V. Navarrete-Carriola, Marlet Martínez-Archundia, Marhian López-Vargas, Liliana Argueta-Figueroa, Lenci K. Vázquez-Jiménez, Alma D. Paz-González, Eyra Ortiz-Pérez, Michael P. Doyle, Gildardo Rivera   +10 more
doaj   +1 more source