Results 91 to 100 of about 169 (158)

Polypharmacy burden and incident epilepsy among older adults in the United States

Epilepsia Open, Volume 11, Issue 4, Page 1370-1381, August 2026.
Abstract Objectives To estimate the prevalence of polypharmacy among older adults with incident epilepsy and to describe the most common combinations of drug classes filled prior to epilepsy diagnosis. Polypharmacy—the concurrent use of multiple medications—is common in older adults with epilepsy, but little is known about its burden and specific ...
Galen Shearn‐Nance, Long Vu, Hannah L. Fein, Wyatt P. Bensken, Jorden G. Rieke, Martha Sajatovic, Gena Ghearing, David F. Warner, Siran M. Koroukian, Nicholas K. Schiltz   +9 more
wiley   +1 more source

Combining electroacupuncture and transcutaneous electrical acupoint stimulation for psychiatric disorders in women victims of domestic violence: An assessor‐blinded, randomised controlled trial

General Psychiatry, Volume 39, Issue 4, August 2026.
ABSTRACT Background Women victims of domestic violence often present with psychiatric disorders and may benefit from nonpharmacological interventions. Acupoint stimulation therapy may be an effective approach. Aims To examine whether a combination of electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS) can alleviate ...
Sichang Yang, Wai Chun Mok, Denise Shuk Ting Cheung, Agnes Tiwari, Calvin Pak Wing Cheng, Haiyong Chen, Zongshi Qin, Mei Yan Chan, Xiaoru Hu, Kam Chi Yu, Pui Yan Chan, Wenqi Li, Sheng‐Nan Liu, Min‐Qing Gu, Xinjing Yang, Doris Lee, Sai Ho Sin, Zhang‐Jin Zhang   +17 more
wiley   +1 more source

Development and Validation of an XGBoost‐SHAP Model for Predicting Adverse Outcomes in Elderly Cardiovascular Patients With Polypharmacy: A Retrospective Cohort Study

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT This study aims to develop and validate an interpretable machine learning model using Extreme Gradient Boosting (XGBoost) with SHapley Additive exPlanations (SHAP) analysis to predict adverse outcomes in elderly cardiovascular patients with polypharmacy. This retrospective cohort study included 1200 patients aged ≥ 65 years with cardiovascular
Kun Wang, Dandan Cao
wiley   +1 more source

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Delirium is a frequent complication in comatose Out‐of‐Hospital Cardiac Arrest (OHCA) survivors requiring postresuscitation intensive care and is associated with higher mortality and longer hospitalization. Despite this, there is no established pharmacologic strategy for delirium prevention in OHCA survivors.
Benedikte Liebetrau, Anders M. Grejs, Martin A. S. Meyer, Lars P. K. Andersen, Sören Möller, Simon Mølstrøm, Jacob E. Møller, Henrik Schmidt, Steffen Christensen, Jesper Kjærgaard, Christian Hassager, Bodil S. Rasmussen, Jo B. Andreasen   +12 more
wiley   +1 more source

Prolactin in high‐metabolic risk pregnancies: Associations with maternal obesity and metabolic health

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 8, Page 1490-1501, August 2026.
Higher maternal BMI before and during early pregnancy is associated with lower prolactin levels across gestation and a reduced prolactin rise. Prolactin in pregnancy may reflect maternal metabolic health and has potential relevance to lactation outcomes.
Kate Rassie, Simon Alesi, Adriana C. H. Neven, Taitum Mason, Eveline Jona, Stacey J. Ellery, Joanne Enticott, Aya Mousa, Anju E. Joham, David Simmons, Helena Teede, on behalf of the TOBOGM Core Investigator Group   +11 more
wiley   +1 more source

Medication Burden: Beyond Counts to Recognize Polypharmacy as an Inherent Part of Living With Chronic Kidney Disease

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Medication burden in older patients with chronic kidney disease (CKD) is substantial, and simple medication counts are insufficient for identifying those at elevated risk of inappropriate prescribing. This study characterized medication burden by assessing the number of medications, potentially inappropriate medications (PIMs) and ...
Morten Baltzer Houlind, Helle Gybel Juul‐Larsen, Charlotte Strandhave, Niels Westergaard, Anne Estrup Olesen   +4 more
wiley   +1 more source

Psychotropic Prescribing Patterns Among Bipolar‐I Patients Prior to Established Bipolar‐I Disorder Diagnosis

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objective Bipolar I Disorder (BP‐I) is frequently misdiagnosed as Major Depressive Disorder (MDD), delaying appropriate treatment. This study aimed to examine treatment patterns among BP‐I patients misdiagnosed with MDD and assess the impact of these regimens on the time until BP‐I diagnosis.
Filmon Haile, Clayton English, Kyueun Lee   +2 more
wiley   +1 more source

Epigenetic Age Accelerations and the Clinical Presentation of Bipolar Disorders: A Latent Profile Analysis in the FACE‐BD Sample

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Epigenetic age accelerations have been associated with the clinical expression of BD; however, with few available studies. Method We calculated Horvath, Hannum, EN, GrimAge, and PhenoAge epigenetic ages in a sample of 139 individuals with BD.
Luana Spano, Céline Bourdon, Mohamed Lajnef, Ophélia Godin, Marion Leboyer, Katia M'Bailara, Antoine Lefrere, Raoul Belzeaux, Philippe Courtet, Emilie Olie, Caroline Dubertret, Raymund Schwan, Paul Roux, Mircea Polosan, Ludovic Samalin, FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators, B. Etain, E. Olié, M. Leboyer, E. Haffen, P. M. Llorca, V. Barteau, S. Bensalem, O. Godin, S. Hotier, A. Macone, A. Pelletier, C. Pin, C. Dominique, C. Lam, J. Lantier, F. Harter, V. Nicolaidis, F. Bellivier, B. Etain, V. Hennion, E. Marlinge, B. Aouizerate, N. Da Ros, C. Elkael, S. Gard, F. Hoorelbcke, K. M'Bailara, I. Minois, J. Sportich, M. Benramdane, L. Boukhobza, P. Courtet, B. Deffinis, D. Ducasse, M. Gachet, E. Olié, E. Palmeri, G. Tarquini, M. Cermolacce, A. Lefrere, E. Moreau, H. Polomeni, F. Groppi, J. Baurberg, L. Lescalier, I. Murracioli, A. Surray, E. Cosker, R. Schwan, A. Bertrand, J. Pastol, B. Fredembach, Q. Denoual, E. Winiarski, A. Pouchon, M. Polosan, C. Passerieux, L. Brehon, L. Durand, S. Frileux, V. Feuga, P. Roux, E. Vaux, C. Dubertret, N. Mazer, P. Laurent, C. Beal, O. Blanc, T. Bonnet, M. Gambier, C. Garcin, D. Lacelle, P. M. Llorca, L. Samalin, Frank Bellivier, Cynthia Marie‐Claire, Bruno Etain   +92 more
wiley   +1 more source

Smoking Initiation, Age at Onset of Symptoms and Suicide Attempts Among Patients With Bipolar Disorder: Comparisons With Non‐Psychiatric Adults

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Introduction The prevalence of tobacco smoking and high nicotine dependence (ND) in bipolar disorder (BD) is higher than in the general population but lower than in schizophrenia. This study aims to analyse the relationship of smoking behaviours, including age at onset of daily smoking (AODS), with age at onset of BD and course‐of‐illness ...
Manuel Gurpegui, Luis Gutiérrez‐Rojas, José M. Martínez‐Ortega, Jesús García‐Jiménez, Sara Jiménez‐Fernández, Pablo J. González‐Domenech, Lucía Pérez‐Costillas   +6 more
wiley   +1 more source

Establishing a Specialty Bipolar Clinic: The National Network of Depression Centers Consensus Recommendations

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objective To provide expert recommendations for the development of a specialty bipolar clinic that promotes best clinical practices for the delivery of safe and effective care. Methods Members of the National Network of Depression Centers (NNDC) Bipolar Clinics Work Group met in a series of 1‐h monthly video calls over 18 months to discuss all
Christopher D. Schneck, Jorge R. C. Almeida, David J. Bond, Katherine E. Burdick, Mark A. Frye, Fernando S. Goes, Rebekah S. Huber, Rodrigo Machado‐Vieira, Pamela Mahon, Melvin G. McInnis, John Nurnberger, Dost Ongur, Michael J. Ostacher, Sagar V. Parikh, Kristin S. Raj, Matteo Respino, Barbara W. Schweizer, Jair C. Soares, Sarah H. Sperry, Aimee E. Sullivan, Trisha Suppes, Marin Veldic, Peter P. Zandi, J. Raymond DePaulo   +23 more
wiley   +1 more source