Results 101 to 110 of about 169 (158)

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Cardiovascular Disease Risk Prediction in Patients With Metabolic Dysfunction‐Associated Steatohepatitis

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7058-7072, August 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH) is associated with an increased risk of cardiovascular disease (CVD) morbidity and mortality. This study aimed to develop the first prediction models for CVD risk in a cohort of patients with MASH.
Joe Hollinghurst, Margarida Augusto, Fotis Tefos, Robert Bauer, Sreelatha Vadapalle, Lise Gehrt Cardél   +5 more
wiley   +1 more source

Risk of Psychiatric Worsening With GLP‐1 Receptor Agonist Use in Patients With Type 2 Diabetes and Treated Depression

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7048-7057, August 2026.
ABSTRACT Aims To compare 1‐year psychiatric outcomes after GLP‐1 receptor agonist (GLP‐1 RA) versus sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) initiation in patients with type 2 diabetes and treated depression. Materials and Methods We conducted a retrospective active‐comparator, new‐user cohort study using electronic health records from the ...
Yu Chang, Ming‐Hong Hsieh, Po‐Chung Ju, Cheng‐Chen Chang   +3 more
wiley   +1 more source

Longitudinal Dietary Intake of Young People With a First Episode of Psychosis From the Time of Presentation to Six Months Follow‐Up

Early Intervention in Psychiatry, Volume 20, Issue 8, August 2026.
ABSTRACT Background Antipsychotic medications stimulate appetite and weight gain, contributing to high obesity rates in people with psychotic disorders. It is unknown if these dietary effects habituate over time. This study aimed to determine the dietary intake of young people with a first‐episode psychosis at the time of presentation and at three‐ and
Brian O'Mahony, Andrew Thompson, Adele Morrin, Brian O'Donoghue   +3 more
wiley   +1 more source

Medication Non‐Adherence in First Episode Psychosis: A Systematic Review

Early Intervention in Psychiatry, Volume 20, Issue 8, August 2026.
ABSTRACT Objective Despite the efficacy of antipsychotics, medication non‐adherence remains common among individuals with a First Episode of Psychosis (FEP). Methods A systematic review was conducted in accordance with the PRISMA 2020 guidelines to summarise the existing evidence base regarding the reasons, attitudes, and beliefs underlying both ...
James Hunt, Anna Georgiades
wiley   +1 more source

‘Traumatic to Say the Least; It Still Affects Me’: Consumer Perspectives on Community Treatment Orders in Australia

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Background Community Treatment Orders (CTOs) are contested practices in mental healthcare due to unresolved evidence of effectiveness and persistent human rights concerns. Despite this, Australia has high rates of CTO use internationally. Research from a lived and living experience (LLE) perspective remains limited.
Sharon Lawn, Tessa‐May Zirnsak, T. J. Spencer, Elaine Waddell, Jane Fischer, Tarmia Klass, Puneet Sansanwal, Edwina T. Light, Vrinda Edan, Chris Maylea, Penelope Weller, Morgan Gould, Christopher J. Ryan, Giles Newton‐Howes, Steve Kisely, Lisa Brophy   +15 more
wiley   +1 more source

Successful Treatment of Rapid Cycling Bipolar Disorder With Lurasidone, Clozapine, and Valproate: A Case Report

Bipolar Disorders, Volume 28, Issue 5, August 2026.
Petr Potměšil, Miloslav Kopeček, Veronika Andrashko   +2 more
wiley   +1 more source

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Overdosage with antipsychotic agents

American Journal of Psychiatry, 1980
M D, Allen, D J, Greenblatt, B J, Noel
openaire   +2 more sources

Antipsychotic agent as an etiologic agent of IFIS

Journal of Cataract and Refractive Surgery, 2005
Edward, Pringle, Richard, Packard
openaire   +2 more sources