Results 241 to 250 of about 275,477 (365)

A natural variation in the promoter of TaGDSL‐7D contributes to grain weight and yield in wheat

Plant Biotechnology Journal, EarlyView.
Summary Grain weight (GW) is a critical agronomic trait that greatly impacts wheat yield, yet the underlying genetic factors remain largely unknown. Here, we identify and characterize a candidate gene TaGDSL‐7D controlling GW in wheat through map‐based cloning, which encodes an ER‐located GDSL‐family protein.
Fei He, Dejie Du, Zhaoyan Chen, Liang Ma, Yunjie Liu, Zhaoju Li, Long Song, Zihao Jiang, Yujie Fan, Qixin Sun, Zhongfu Ni   +10 more
wiley   +1 more source

The Highly Conserved Cys95 Residue of Fructose‐1,6‐Bisphosphatase 1 Mediates the pH‐Driven Structure and Activity of the Enzyme and Photosynthesis

Plant, Cell &Environment, EarlyView.
ABSTRACT In Arabidopsis, exposure to microbial volatile compounds promotes thiol reduction of the Cys95 residue of the photosynthetic enzyme fructose‐1,6‐bisphosphatase (cFBP1). Although highly conserved in plants, the Cys95 function still remains unknown. We characterised recombinant wild‐type (WT) cFBP1 and a variant (C95S) in which the Cys95 residue
Samuel Gámez‐Arcas, Edurne Baroja‐Fernández, Francisco José Muñoz, Antonio J. Serrato, Mónica Balsera, Ángela María Sánchez‐López, Abdellatif Bahaji, Jesús Leal‐López, Rafael Jorge León Morcillo, Javier Pozueta‐Romero   +9 more
wiley   +1 more source

The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia cells

, 1996
Peter T. Rowley, Peter C. Keng, Barbara A. Kosciolek   +2 more
openalex   +1 more source

Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking. [PDF]

Chem Sci
Kashyap D, Milne TA, Booth MJ.
europepmc   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Neuron, 2016
Jie Jiang, Qiang Zhu, Tania F. Gendron, Shahram Saberi, Melissa McAlonis-Downes, A. Seelman, J. Stauffer, P. Jafar‐nejad, Kevin Drenner, Derek Schulte, S. Chun, Shuying Sun, Shuo-Chien Ling, Brian Myers, J. Engelhardt, Melanie Katz, Michael W. Baughn, O. Platoshyn, M. Marsala, A. Watt, C. Heyser, M. Ard, Louis De Muynck, Lillian M. Daughrity, Debbie Swing, L. Tessarollo, Chris J. Jung, Arnaud Delpoux, Daniel T. Utzschneider, Stephen M. Hedrick, Pieter J. de Jong, D. Edbauer, Philip Van Damme, L. Petrucelli, Christopher E. Shaw, C. F. Bennett, Sandrine Da Cruz, J. Ravits, F. Rigo, Don W. Cleveland, C. Lagier-Tourenne   +40 more
semanticscholar   +1 more source

The expanding application of antisense oligonucleotides to neurodegenerative diseases. [PDF]

J Clin Invest
Sumner CJ, Miller TM.
europepmc   +1 more source

Optimisation of Heated Electrospray Ionisation Parameters to Minimise In‐Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics

Rapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Rationale Oligonucleotides have emerged as an important new class of therapeutic. Due to their structural complexity, this presents significant challenges for the development of analytical methods to characterise and determine their impurity profile.
Mollie A. Glenister, Ulrik Mistarz, Ken Cook, James L. Stephenson, Mark J. Dickman   +4 more
wiley   +1 more source

In vivo transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate‐salt hypertension in rats [PDF]

, 2000
Izumi Hayashi, Masataka Majima, Tomoe Fujita, Toshiaki Okumura, Yuji Kumagai, Naruya Tomita, Ryuichi Morishita, Jitsuo Higaki, Ogiwara Toshio   +8 more
openalex   +1 more source

Antisense oligonucleotides as a precision therapy for developmental and epileptic encephalopathies. [PDF]

CNS Neurosci Ther
Quilón PG, Volpedo G, Cappato S, Ferrera L, Zara F, Bocciardi R, Riva A, Striano P.   +7 more
europepmc   +1 more source