Results 1 to 10 of about 61,173 (287)

Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation [PDF]

Thrombosis Journal
Background Antithrombin, a key regulator of the coagulation cascade, is often decreased in patients with sepsis-associated disseminated intravascular coagulation (DIC).
Tomoki Tanigawa, Toshiaki Iba, Cheryl L. Maier, Ecaterina Scarlatescu, Yutaka Kondo, Hideo Wada, Jerrold H. Levy   +6 more
doaj   +2 more sources

Antithrombin deficiency is associated with mortality and impaired organ function in septic pediatric patients: a retrospective study [PDF]

PeerJ, 2018
Background Sepsis remains a major problem in intensive care medicine. It is often accompanied by coagulopathies, leading to thrombotic occlusion of small vessels with subsequent organ damage and even fatal multi-organ failure.
Christian Niederwanger, Tobias Hell, Sophie Hofer, Christina Salvador, Miriam Michel, Bettina Schenk, Benedikt Treml, Mirjam Bachler   +7 more
doaj   +3 more sources

Antithrombin-III for New Coronavirus Infection (COVID-19) Under Conditions of Extracorporeal Membrane Oxygenation (Clinical Observation)

Неотложная медицинская помощь, 2022
COVID-19 is a disease that, in addition to respiratory failure, leads to thrombosis and bleeding due to coagulation disorders. Extracorporeal membrane oxygenation (ECMO), required in cases of a deterioration of gas exchange function of the lungs ...
S. V. Zhuravel, V. V. Vladimirov, P. V. Gavrilov, I. V. Ivanov, S. S. Petrikov, K. A. Popugayev, A. M. Talyzin   +6 more
doaj   +3 more sources

Distinction of two pathologic antithrombin III molecules: Antithrombin III ‘Aalborg’ and antithrombin III ‘Budapest’

Thrombosis Research, 1982
Plasma from two different thrombophilic families with functional inherited antithrombin III deficiency, i.e., with low antithrombin III activity but normal immunoreactive antithrombin III concentration, were investigated simultaneously in the same laboratory.
P J, Sørensen, G, Sas, I, Petó, G, Blaskó, T, Kremmer, A, Samu   +5 more
openaire   +4 more sources

Coagulation profile in bitches with pyometra: Standard tests and thromboelastography [PDF]

Veterinární Medicína
This study aimed to determine coagulation changes in bitches with pyometra based on a series of coagulation tests and thromboelastography (TEG), and to assess the incidence of disseminated intravascular coagulation (DIC).
A Ramesova, K Machackova, I Vanova, M Lacinova, A Bartoskova, R Novotny, R Vitasek, K Rehakova, J Doubek   +8 more
doaj   +2 more sources

The Effect of Postoperative Antithrombin Supplementation on the Inflammatory and Coagulation Status of a Surgically Treated Patient With a Malignant Tumor in the Small Pelvis—Case Series [PDF]

Cancer Reports
Introduction Antithrombin has the function of a natural anticoagulant. It is the main component of the inhibitory anticoagulant system, which, under physiological conditions, opposes the procoagulant mechanisms of hemostasis, preventing the occurrence of
Ranko Lazović, Ognjenka Šarenac
doaj   +2 more sources

In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy

Science Advances, 2022
Hemophilia is a hereditary disease that remains incurable. Although innovative treatments such as gene therapy or bispecific antibody therapy have been introduced, substantial unmet needs still exist with respect to achieving long-lasting therapeutic ...
J. Han, MinJeong Kim, B. Choi, Jeong Hyeon Lee, G. Lee, M. Jeong, Yeji Lee, Eun-Ah Kim, Hye-Kyung Oh, Nanyeong Go, Hyerim Lee, K. J. Lee, U. Kim, J. Y. Lee, Seokjoong Kim, Jun Chang, Hyukjin Lee, D. Song, S. Yeom   +18 more
semanticscholar   +1 more source

Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes

Frontiers in Immunology, 2022
IntroductionTrauma activates the innate immune system to modulate hemostasis and minimize the damage caused by physiological bodily responses, including the activation of coagulation.
Takeshi Wada, Atsushi Shiraishi, Satoshi Gando, Satoshi Gando, Daijiro Kabata, Kazuma Yamakawa, Seitaro Fujishima, Daizoh Saitoh, Shigeki Kushimoto, Hiroshi Ogura, Toshikazu Abe, Toshikazu Abe, Toshihiko Mayumi, Yasuhiro Otomo   +13 more
doaj   +1 more source

Antithrombin activity levels for predicting long-term outcomes in the early phase of isolated traumatic brain injury

Frontiers in Immunology, 2022
Coagulopathy management is an important strategy for preventing secondary brain damage in patients with traumatic brain injury (TBI). Antithrombin (AT) is a natural anticoagulant that controls coagulation and inflammation pathways.
Masaki Takahashi, Takeshi Wada, Ryuta Nakae, Yu Fujiki, Takahiro Kanaya, Yasuhiro Takayama, Go Suzuki, Yasutaka Naoe, Shoji Yokobori   +8 more
doaj   +1 more source

Interactions of marine sulfated glycans with antithrombin and platelet factor 4

Frontiers in Molecular Biosciences, 2022
The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT).
Wenjing Zhang, Weihua Jin, Weihua Jin, Vitor H. Pomin, Fuming Zhang, Robert J. Linhardt, Robert J. Linhardt   +6 more
doaj   +1 more source