Results 21 to 30 of about 9,077 (143)

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Influence of patient factors on target plasma volume treated attainment rate during double filtration plasmapheresis in patients with hypertriglyceridemic acute pancreatitis

Therapeutic Apheresis and Dialysis, EarlyView.
Abstract Introduction This study aims to investigate patient factors affecting the rate of plasma volume target attained in hypertriglyceridemic pancreatitis (HTG‐AP) patients undergoing double filtration plasmapheresis (DFPP). Methods A retrospective analysis of 82 HTG‐AP‐interpreted patients from January 2019 to April 2024 compared target plasma ...
Hui Zhang, Chenqiang Zhu, Yunlong Wu
wiley   +1 more source

Bleeding Disorders in Children With Genetic Diseases: A Narrative Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol, Mariam Sbeity Barakat, Marjolaine Willems, Tasnime Akbaraly, Biron‐Andreani Christine, Isabelle Diaz, Alexandre Theron   +6 more
wiley   +1 more source

Coexistence of antithrombin deficiency and suspected inferior vena cava atresia in an adolescent and his mother – case report and clinical implications [PDF]

, 2021
Merle Müller-Knapp, Carl-Friedrich Classen, Ralf Knöfler, Christian Spang, Christina Hauenstein, T. Heinrich, Fatine Gabriel, Jan Däbritz, Daniel A. Reuter, Johannes Ehler   +9 more
openalex   +1 more source

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble, S. H. White‐Springer, S. Alpini, E. Rumfola, A. N. DiSilvestro, Y. Ueda, K. Hobbs   +6 more
wiley   +1 more source

ROLE OF INDICATORS OF THE HEMOSTASIS IN PATHOGENESIS ESOPHAGEAL AND GASTRIC BLEEDINGS AT PORTAL HYPERTENSIA AT CHILDREN

Мать и дитя в Кузбассе, 2018
The article analyzes the examination of 67 children with extrahepatic block of portal hypertension. To provide evaluation of hemostasis all children were determined in coagulative, fiber thrombocytic hemostasis, the intensity of fibrinolysis and ...
Вадим Александрович Дударев, Марина Юрьевна Галактионова   +1 more
doaj  

Adverse events in patients initiated on dabigatran etexilate therapy in a pharmacist-managed anticoagulation clinic

Pharmacy Practice, 2013
Background: Vitamin K antagonists have been the treatment of choice in preventing thromboembolic events, but problems such as frequent dose adjustment and monitoring of coagulation status, including multiple drug and food interactions, make their use ...
Donaldson M, Norbeck AO
doaj  

Evaluation of clinical pharmacy services in patients receiving antithrombotic treatment in a randomized controlled trial

Scientific Reports
Patients receiving antithrombotic therapy are at increased risk of drug-related problems (DRPs) due to the complexity of their regimens and high-risk pharmacological profiles.
Damla Sosyal, Muhammed Yunus Bektay, Nusret Acikgoz, Fikret Vehbi Izzettin   +3 more
doaj   +1 more source

Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley   +1 more source