Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents [PDF]
Molecules, 2018 Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (
Samir M. Awad +4 more
doaj +2 more sources
Prevalence, Treatment Status, and Comorbidities of Hyperthyroidism in Korea from 2003 to 2018: A Nationwide Population Study [PDF]
Endocrinology and Metabolism, 2023 Background This study aimed to investigate the changes of incidence and treatment of choice for hyperthyroidism from 2003 to 2018 and explore the treatment-related complications and concomitant comorbidities in South Korea using data from the National ...
Hwa Young Ahn +6 more
doaj +1 more source
Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study [PDF]
Endocrinology and Metabolism, 2022 Background Hyperthyroidism is associated with an increased glomerular filtration rate (GFR) in the hyperdynamic state, which is reversible after restoring euthyroidism.
Yoon Young Cho +10 more
doaj +1 more source
Prediction of the recurrence risk of Graves' disease after antithyroid drug therapy
Environmental Disease, 2023 Objective: This study aimed at observing the prognostic factors for Graves' disease (GD) recurrence after treatment with antithyroid drugs. Patients and Methods: Clinical data for 247 patients with primary GD hyperthyroidism diagnosed in the ...
Qiang Zhang, Ying Fu
doaj +1 more source
Antithyroid arthritis syndrome caused by methimazole in a patient with Graves’ disease
Endocrinology, Diabetes & Metabolism Case Reports, 2023 This is a report on antithyroid arthritis syndrome (AAS) which is a rare adverse effect of antithyroid agents. AAS presents with severe symptoms including myalgia, arthralgia, arthritis, fever, and skin eruption due to the use of antithyroid agents.
Muneo Kawasumi +3 more
doaj +1 more source
Factors affecting drug-induced liver injury: antithyroid drugs as instances [PDF]
Clinical and Molecular Hepatology, 2014 Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications.
Reza Heidari +3 more
doaj +1 more source
Remission in pediatric Graves’ disease treated with antithyroid drug and the risk factors associated with relapse [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2022 Purpose To evaluate the characteristics and frequency of remission in pediatric patients with Graves’ disease (GD) treated with antithyroid drug (ATD) and to identify factors that may be associated with relapse.
Tsz Wai Catherine Wong +1 more
doaj +1 more source
An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]
Advanced Pharmaceutical Bulletin, 2015 Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari +4 more
doaj +1 more source
ABC approach for the management of adults with hyperthyroidism: A practical strategy in primary care [PDF]
Malaysian Family Physician, 2023 Hyperthyroidism is commonly seen in primary care settings. However, the management of hyperthyroidism might be unclear to primary care doctors. Various guidelines have been published to assist clinicians in the management of thyroid disorders at various ...
Jazlan Jamaluddin +6 more
doaj +1 more source
Antithyroid Drug Treatment in Graves’ Disease [PDF]
Endocrinology and Metabolism, 2021 Graves’ disease is associated with thyrotropin (TSH) receptor stimulating antibody, for which there is no therapeutic agent. This disease is currently treated through inhibition of thyroid hormone synthesis or destruction of the thyroid gland. Recurrence
Jae Hoon Chung
doaj +1 more source