Results 161 to 170 of about 8,118 (201)
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Pharmacokinetics of antithyroid drugs
Klinische Wochenschrift, 1982Studies of antithyroid drug pharmacokinetics suffer from the lack of simple and sensitive methods for the measurement of these drugs in biologic fluids. This is reflected by most of the data available at present. From a critical review of these studies, the following conclusions emerge:
G, Benker, D, Reinwein
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Hormone Research, 2008
The management of the antithyroid drug therapy is inferred from the preceding papers. The best duration for the treatment with antithyroid drugs (ATD) is 18 months. At the end of the treatment, the early radioiodine uptake measured on suppressive doses of LT3 and the determination of the thyroid-stimulating antibodies are the only two interesting ...
Katja Sibyile Mühlberg, Ralph Paschke
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The management of the antithyroid drug therapy is inferred from the preceding papers. The best duration for the treatment with antithyroid drugs (ATD) is 18 months. At the end of the treatment, the early radioiodine uptake measured on suppressive doses of LT3 and the determination of the thyroid-stimulating antibodies are the only two interesting ...
Katja Sibyile Mühlberg, Ralph Paschke
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New England Journal of Medicine, 1984
Over the past four decades, a great deal has been learned about the pharmacology and mechanisms of action of antithyroid drugs. Their ability to inhibit hormone biosynthesis involves complex interactions with thyroid peroxidase and thyroglobulin, many of which are still poorly understood. Their spectrum of activity is much wider than previously thought,
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Over the past four decades, a great deal has been learned about the pharmacology and mechanisms of action of antithyroid drugs. Their ability to inhibit hormone biosynthesis involves complex interactions with thyroid peroxidase and thyroglobulin, many of which are still poorly understood. Their spectrum of activity is much wider than previously thought,
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Antithyroid drugs and congenital malformations
Nature Reviews Endocrinology, 2018A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the ...
Korevaar, Tim, Peeters, Robin
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TOXICITY OF THE ANTITHYROID DRUG CARBIMAZOLE
The Journal of Clinical Endocrinology & Metabolism, 1956In The twelve years which have elapsed since the introduction of thiourea in the treatment of thyrotoxicosis, other antithyroid drugs have replaced it in turn, each introduced in the hope that it would prove equally efficacious but less toxic. One of the more recent is 2-carbethoxythio-1-methyl-glyoxaline (syn., carbimazole B.P.; Neo-mercazole) first ...
R, GREENE, D C, MORGAN
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Rethinking antithyroid drugs in pregnancy
Clinical Endocrinology, 2014SummaryUncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice of antithyroid drug has not ...
Napier C, Pearce SHS
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Clinical Pharmacokinetics of Antithyroid Drugs
Clinical Pharmacokinetics, 1981Organic antithyroid drugs used today include propylthiouracil and the mercaptoimidazolines, carbimazole and methimazole. They can be measured with accuracy and in small quantities in serum by gas-liquid chromatography, high performance liquid chromatography and radio-immunoassay. Bioavailability of these drugs varies from 80 to 95%.
J P, Kampmann, J M, Hansen
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The safety and efficacy of antithyroid drugs
Expert Opinion on Drug Safety, 2005Thionamides, selective inhibitors of thyroid peroxidase-mediated iodination by tyrosine residues in thyroglobulin, have been effectively used in the treatment of hyperthyroidism. The choices for initial treatment of patients with Graves' disease differ in various countries, and many physicians around the world prefer to administer thionamide drugs as ...
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Hepatotoxicity from Antithyroid Drugs
Hormone Research, 2008We review the cases of hepatic injury from propylthiouracil, methimazole and carbimazole in the English language literature and compare them to cases of agranulocytosis in a recent review. The data on hepatotoxicity confirm the findings for agranulocytosis that low-dose methimazole is safer than propylthiouracil and that methimazole toxicity is more ...
A C, Vitug, J M, Goldman
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Bronchial Asthma Induced by an Antithyroid Drug
Chest, 2001We report the case of a 67-year-old woman who suffered from a severe asthma exacerbation as a consequence of an antithyroid drug treatment prescribed for her multinodular, hyperfunctioning goiter. Asthma symptoms were associated with a very significant increase in the number of eosinophils, detected in both blood and induced sputum.
GREMBIALE RD +5 more
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