Results 161 to 170 of about 12,171 (216)
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New England Journal of Medicine, 1984
Over the past four decades, a great deal has been learned about the pharmacology and mechanisms of action of antithyroid drugs. Their ability to inhibit hormone biosynthesis involves complex interactions with thyroid peroxidase and thyroglobulin, many of which are still poorly understood. Their spectrum of activity is much wider than previously thought,
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Over the past four decades, a great deal has been learned about the pharmacology and mechanisms of action of antithyroid drugs. Their ability to inhibit hormone biosynthesis involves complex interactions with thyroid peroxidase and thyroglobulin, many of which are still poorly understood. Their spectrum of activity is much wider than previously thought,
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The Origin of Antithyroid Drugs
Thyroid®, 2023Background: When the antithyroid drugs were discovered in the early 1940s, they were immediately recognized as a revolutionary new treatment for hyperthyroidism. Although much has been learned about their mechanism of action and clinical utility, they continue to be used today in much the same way as they have been since their introduction. Summary: In
Clark T, Sawin, David S, Cooper
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Hepatotoxicity from Antithyroid Drugs
Hormone Research, 1985We review the cases of hepatic injury from propylthiouracil, methimazole and carbimazole in the English language literature and compare them to cases of agranulocytosis in a recent review. The data on hepatotoxicity confirm the findings for agranulocytosis that low-dose methimazole is safer than propylthiouracil and that methimazole toxicity is more ...
A C, Vitug, J M, Goldman
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Pharmacokinetics of antithyroid drugs
Klinische Wochenschrift, 1982Studies of antithyroid drug pharmacokinetics suffer from the lack of simple and sensitive methods for the measurement of these drugs in biologic fluids. This is reflected by most of the data available at present. From a critical review of these studies, the following conclusions emerge:
G, Benker, D, Reinwein
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Antithyroid drugs and congenital malformations
Nature Reviews Endocrinology, 2018A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the ...
Korevaar, Tim, Peeters, Robin
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Long-term antithyroid drug therapy
Current Opinion in Endocrinology, Diabetes & Obesity, 2021Purpose of review Over the last 1–2 decades, patients and physicians have preferred antithyroid drug therapy as the initial treatment of Graves’ disease, rather than radioactive iodine or surgery. More recently, the concept of long-term antithyroid drug therapy (LTADT; >24 months of treatment) has also become increasingly ...
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Clinical Pharmacokinetics of Antithyroid Drugs
Clinical Pharmacokinetics, 1981Organic antithyroid drugs used today include propylthiouracil and the mercaptoimidazolines, carbimazole and methimazole. They can be measured with accuracy and in small quantities in serum by gas-liquid chromatography, high performance liquid chromatography and radio-immunoassay. Bioavailability of these drugs varies from 80 to 95%.
J P, Kampmann, J M, Hansen
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